Treatment of intestinal helminthiasis: mebendazole only or mebendazole-pyrantel pamoate?
Keywords:
helminthiasis, mebendazol, pyrantel pamoate, Ascaris lumbricoides, Trichuris trichiura, hookworm
Abstract
Background Although intestinal helminthiasis causes highmorbidity and has a negative impact on children’s growth and
development, the efficacy of antihelmintics for multiple
helminthiasis in mass treatment is still doubtful.
Objective To compare the efficacy of single dose mebendazole
and a combination of pyrantel pamoate and mebendazole for the
treatment of multiple infections due to Ascaris lumbricoides,
hookworm, and Trichuris trichiura.
Methods Subjects were elementary school students in Suka Village,
Tiga Panah subdistrict, North Sumatera. They were randomized
to either receive mebendazole (M Group) or mebendazole-
pyrantel pamoate group (MP Group). Stool examinations were
perfomed on each subjects on day 7, 14, 21, and 28 after treatment.
Analyses were perfomed by using chi-squared and Mann-Whitney
U tests.
Results The prevalence of intestinal helminthiasis was 95.4%. T.
trichiura (88.7%) was the most common cause of infection followed
by A. lumbricoides (79.5%), and hookworm (3.1%). Two hundred
thirty nine (76.8%) children had multiple infections. Although
the egg reduction rate of intestinal helminthiasis in the
combination group was faster than that of the mebendazole group,
there was no significant difference in the cure rate of both groups.
Conclusion A single dose of mebendazole is preferred for mass
treatment of multiple intestinal helminthiasis infections.
References
1. Crompton DWT, Montresor A, Nesheim MC, Savioli L,
editors. Controlling disease due to helminth infections.
Geneva: WHO; 2003.
2. Sasongko A. Duabelas tahun pelaksanaan program
pemberantasan cacingan di sekolah-sekolah dasar DKI
Jakarta (1987–1999). J Epidemiol Indones 2000;4:41-51.
3. Gani EH. Efek ovisidal mebendazol dan albendazol terhadap
Ascaris lumbricoides dan Trichuris trichura [thesis]. Medan:
Universitas Sumatera Utara; 1997.
4. Warren KS, Bundy DAP, Anderson RM. Helminth infection.
In: Jamison DT, Mosley WH, Measham AR, Bobadilla JL,
editors. Priorities in developing countries. New York: Oxford
University Press; 1999. p. 131-60.
5. Pasaribu S. Anthelmintik generasi baru. Proceedings of the
One Day Simposium “Anthelmintik generasi baruâ€;1989
;Medan.
6. Abadi K. Single dose mebendazole therapy for soil-transmitted
nematodes. Am J Trop Med Hyg 1985;34:129-33.
7. Abidin SAN, Rassad R. Pengobatan infeksi nematoda usus
dengan mebendazole 500 mg dosis tunggal. MEDIKA
1990;3:192-7.
8. Hadju V, Abadi K, Stephenson LS, Noor NN, Mohammed
HO, Bowman DD. Intestinal helminthiasis, nutritional status,
and their relationship; a cross-sectional study in urban slum
school children in Indonesia. Southeast Asian J Trop Med
Public Health 1995;26:719-29.
9. Norhayati M, Zainuddin B, Mohammod CG, Oothuman P,
Azizi O, Fatmah MS. The prevalence of trichuris, ascaris and
hookworm infection in orang asli children. Southeast Asian
J Trop Med Public Health 1997;28:161-8.
10. Merid Y, Hegazy M, Mekete G, Teklemariam S. Intestinal
Helminthic infection among children at Lake Awassa Area,
South Ethiopia. Ethiop J Health Dev 2001;15:31-8.
11. Clewes CAN, Rousham EK, Taylor CGNM, Lunn PG.
Anthelmintic treatment of rural Bangladeshi children: effect
on host physiology, growth and biochemical status. Am J Clin
Nutr 2001;73:53-60.
12. Albonico M, Stoltzfus, Savioli L, Chwaya HM, d’Harcourt
E, Tielsch JM. A controlled evaluation of two school-based
anthelminthic chemotherapy regimens on intensity of
intestinal helminth infections. Int J Epidemiol 1999;
28:591-6.
13. Oyewole F, Ariyo F, Sanyaolu A. Intestinal helminthiases
and their control with albendazole among primary
schoolchildren in riverine communities of Ondo State,
Nigeria. Southeast Asian J Trop Med Public Health
2002;33:214-7.
14. Watkins WE, Pollitt E. Effect of removing Ascaris on the
growth of Guatemalan schoolchildren. Pediatrics 1996;
97:871-6.
15. Smith HM, Dekaminsky RG, Niwas S, Soto RJ, Jolly PE.
Prevalence and intensity of infections of Ascaris lumbricoides
and Trichuris trichiura and associated socio-demographic
variables in four rural Honduran communities. Mem Inst
Oswaldo Cruz, Rio de Janeiro 2001;96:303-14.
16. Sutoto J, Indriono. The current prevalence rate of soil
transmitted helminthiasis in Indonesia. Pediatr Indones
1992;32:304-11.
17. Sadjimin T, P Jeanne R. Hubungan antara infestasi cacing
dan prestasi belajar anak sekolah dasar di Kecamatan
Ampana Kota Kabupaten Poso Sulawesi Tengah. J Epidemiol
Indones 2000;4:17-26.
18. Glickman LT, Camara AO, Glickman NW, McCabe GP.
Nematode intestinal parasites of children in rural Guinea,
Africa: prevalence and relationship to geophagia. Int J
Epidemiol 1999;28:169-74.
19. Ismid IS, Subahar R, Darnely, Margono SS, Abidin SAN.
Potensi transmisi Ascaris lumbricoides dan Trichuris trichiura
pasca pengobatan dengan obat cacing. Maj Parasitol Ind
1997;10:66-71.
20. Pasaribu S, Lubis CP. Infestasi cacing usus di bangsal anak
RS.Dr.Pirngadi Medan. MKN 1990;3:195-8.
21. Pasaribu S. Hasil pengobatan oxantel – pirantel pamoat dosis
tunggal pada helminthiasis yang ditransmisikan lewat tanah.
Maj Kedok Indon 1992;42:679-82.
22. Onadeko MO, Ladipo OA. Intestinal parasitic infestation
in rural communities: a focus for primary health care in
Nigeria. Afr J Med Med Sci 1989; 18:289-94.
23. Hayimi M, Sumarti, Hasyimi R. Hubungan malnutrisi dan
infeksi kecacingan pada anak sekolah dasar di daerah (IDT)
Sriamur Bekasi. JEN 1996;2:35-40.
24. Legesse M, Erko B, Medhin G. Efficacy of albendazole and
mebendazole in the treatment of Ascariasis and Trichuriasis
infection. Ethiop Med J 2002; 40:335-43.
25. Jongsuksuntigul P, Jeradit C, Pornpattanakul S, Chanasari
U. A comparative study on the efficacy of albendazole and
mebendazole in the treatment of Ascariasis, Hookworm
infection and Trichuriasis. Southeast Asian J Trop Med Public
Health 1993;4:724-9.
26. Purnomo, Pasaribu MP, Partono F. A comparative study of
pyrantel pamoate and a combination of mebendazole and
pyrantel pamoate in the treatment of soil transmitted
helminths in a rural area, Indonesia. Southeast Asian J Trop
Med Pub Health 1981;12:236-41.
27. Lubis CP. Pengobatan helminthiasis pengalaman klinis di
laboratorium Ilmu Kesehatan Anak FK-USU. Proceedings
of the One Day Simposium “Anthelmintik generasi baruâ€;
1989; Medan.
28. Sorensen E, Ismail M, Amarasinghe DK, Hettiarachchi I.
The efficacy of three anthelminthic drugs given in a single
dose. Ceylon Med J 1996;41:42-5.
29. Kan SP, Chua SC. The efficacy of single doses of mebendazole
plus levamisole in the treatment of Trichuris trichiura and
Ascaris lumbricoides infection. Presented at the 7 th APCO
Parasitologists’ Meeting; 1985; Tokyo.
editors. Controlling disease due to helminth infections.
Geneva: WHO; 2003.
2. Sasongko A. Duabelas tahun pelaksanaan program
pemberantasan cacingan di sekolah-sekolah dasar DKI
Jakarta (1987–1999). J Epidemiol Indones 2000;4:41-51.
3. Gani EH. Efek ovisidal mebendazol dan albendazol terhadap
Ascaris lumbricoides dan Trichuris trichura [thesis]. Medan:
Universitas Sumatera Utara; 1997.
4. Warren KS, Bundy DAP, Anderson RM. Helminth infection.
In: Jamison DT, Mosley WH, Measham AR, Bobadilla JL,
editors. Priorities in developing countries. New York: Oxford
University Press; 1999. p. 131-60.
5. Pasaribu S. Anthelmintik generasi baru. Proceedings of the
One Day Simposium “Anthelmintik generasi baruâ€;1989
;Medan.
6. Abadi K. Single dose mebendazole therapy for soil-transmitted
nematodes. Am J Trop Med Hyg 1985;34:129-33.
7. Abidin SAN, Rassad R. Pengobatan infeksi nematoda usus
dengan mebendazole 500 mg dosis tunggal. MEDIKA
1990;3:192-7.
8. Hadju V, Abadi K, Stephenson LS, Noor NN, Mohammed
HO, Bowman DD. Intestinal helminthiasis, nutritional status,
and their relationship; a cross-sectional study in urban slum
school children in Indonesia. Southeast Asian J Trop Med
Public Health 1995;26:719-29.
9. Norhayati M, Zainuddin B, Mohammod CG, Oothuman P,
Azizi O, Fatmah MS. The prevalence of trichuris, ascaris and
hookworm infection in orang asli children. Southeast Asian
J Trop Med Public Health 1997;28:161-8.
10. Merid Y, Hegazy M, Mekete G, Teklemariam S. Intestinal
Helminthic infection among children at Lake Awassa Area,
South Ethiopia. Ethiop J Health Dev 2001;15:31-8.
11. Clewes CAN, Rousham EK, Taylor CGNM, Lunn PG.
Anthelmintic treatment of rural Bangladeshi children: effect
on host physiology, growth and biochemical status. Am J Clin
Nutr 2001;73:53-60.
12. Albonico M, Stoltzfus, Savioli L, Chwaya HM, d’Harcourt
E, Tielsch JM. A controlled evaluation of two school-based
anthelminthic chemotherapy regimens on intensity of
intestinal helminth infections. Int J Epidemiol 1999;
28:591-6.
13. Oyewole F, Ariyo F, Sanyaolu A. Intestinal helminthiases
and their control with albendazole among primary
schoolchildren in riverine communities of Ondo State,
Nigeria. Southeast Asian J Trop Med Public Health
2002;33:214-7.
14. Watkins WE, Pollitt E. Effect of removing Ascaris on the
growth of Guatemalan schoolchildren. Pediatrics 1996;
97:871-6.
15. Smith HM, Dekaminsky RG, Niwas S, Soto RJ, Jolly PE.
Prevalence and intensity of infections of Ascaris lumbricoides
and Trichuris trichiura and associated socio-demographic
variables in four rural Honduran communities. Mem Inst
Oswaldo Cruz, Rio de Janeiro 2001;96:303-14.
16. Sutoto J, Indriono. The current prevalence rate of soil
transmitted helminthiasis in Indonesia. Pediatr Indones
1992;32:304-11.
17. Sadjimin T, P Jeanne R. Hubungan antara infestasi cacing
dan prestasi belajar anak sekolah dasar di Kecamatan
Ampana Kota Kabupaten Poso Sulawesi Tengah. J Epidemiol
Indones 2000;4:17-26.
18. Glickman LT, Camara AO, Glickman NW, McCabe GP.
Nematode intestinal parasites of children in rural Guinea,
Africa: prevalence and relationship to geophagia. Int J
Epidemiol 1999;28:169-74.
19. Ismid IS, Subahar R, Darnely, Margono SS, Abidin SAN.
Potensi transmisi Ascaris lumbricoides dan Trichuris trichiura
pasca pengobatan dengan obat cacing. Maj Parasitol Ind
1997;10:66-71.
20. Pasaribu S, Lubis CP. Infestasi cacing usus di bangsal anak
RS.Dr.Pirngadi Medan. MKN 1990;3:195-8.
21. Pasaribu S. Hasil pengobatan oxantel – pirantel pamoat dosis
tunggal pada helminthiasis yang ditransmisikan lewat tanah.
Maj Kedok Indon 1992;42:679-82.
22. Onadeko MO, Ladipo OA. Intestinal parasitic infestation
in rural communities: a focus for primary health care in
Nigeria. Afr J Med Med Sci 1989; 18:289-94.
23. Hayimi M, Sumarti, Hasyimi R. Hubungan malnutrisi dan
infeksi kecacingan pada anak sekolah dasar di daerah (IDT)
Sriamur Bekasi. JEN 1996;2:35-40.
24. Legesse M, Erko B, Medhin G. Efficacy of albendazole and
mebendazole in the treatment of Ascariasis and Trichuriasis
infection. Ethiop Med J 2002; 40:335-43.
25. Jongsuksuntigul P, Jeradit C, Pornpattanakul S, Chanasari
U. A comparative study on the efficacy of albendazole and
mebendazole in the treatment of Ascariasis, Hookworm
infection and Trichuriasis. Southeast Asian J Trop Med Public
Health 1993;4:724-9.
26. Purnomo, Pasaribu MP, Partono F. A comparative study of
pyrantel pamoate and a combination of mebendazole and
pyrantel pamoate in the treatment of soil transmitted
helminths in a rural area, Indonesia. Southeast Asian J Trop
Med Pub Health 1981;12:236-41.
27. Lubis CP. Pengobatan helminthiasis pengalaman klinis di
laboratorium Ilmu Kesehatan Anak FK-USU. Proceedings
of the One Day Simposium “Anthelmintik generasi baruâ€;
1989; Medan.
28. Sorensen E, Ismail M, Amarasinghe DK, Hettiarachchi I.
The efficacy of three anthelminthic drugs given in a single
dose. Ceylon Med J 1996;41:42-5.
29. Kan SP, Chua SC. The efficacy of single doses of mebendazole
plus levamisole in the treatment of Trichuris trichiura and
Ascaris lumbricoides infection. Presented at the 7 th APCO
Parasitologists’ Meeting; 1985; Tokyo.
Published
2007-10-31
How to Cite
1.
Dalimunthe W, Siregar C, Lubis M, Pasaribu S, Lubis C. Treatment of intestinal helminthiasis: mebendazole only or mebendazole-pyrantel pamoate?. PI [Internet]. 31Oct.2007 [cited 23Nov.2024];47(5):216-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/417
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Received 2016-09-01
Accepted 2016-09-01
Published 2007-10-31
Accepted 2016-09-01
Published 2007-10-31
