Benefits of domperidone in ambulatory acute diarrhea with severe vomiting
Keywords:
domperidone, diarrheal disease, vomiting
Abstract
Background Recently, most patients with diarrheal disease (DD)cases are hospitalized not due to severe dehydration, but due to
severe vomiting which interferes with fluid and food intake. Use
of anti-vomiting medicines is not recommended because of its
“central†side effects. Domperidone has prokinetic and antiemetic
effects with only minimal extrapyramidal side effects.
Objective To evaluate domperidone in preventing hospitalization
of DD patients in outpatient setting.
Methods This randomized double blind, placebo-controlled
clinical trial, was conducted from February to August 2005 at
Mohammad Hoesin Hospital, Palembang. We included patients
aged 6 to 59 months old with acute diarrhea who had vomited at
least 4 times in the last 24 hours, not in need of hospitalization,
and agreed to participate. We excluded patients who had taken
anti-vomiting drug, or those who had severe diseases, including
severe malnutrition. The dose of domperidone was 1.25 mg per 5
kg body weight.
Results There were 183 subjects randomized, consisted of 91 who
took domperidone (treatment group) and 92 who took placebo
(control group). The duration and decrease of vomiting frequency
were significantly different in favor of domperidone. Domperidone
prevented hospitalization significantly (P=0.001, OR=4.1, ARR
= 20%, RRR=71%, NNT=5). No overt acute clinical side effects
were found.
Conclusion Domperidone significantly shortened the duration and
decreased the frequency of vomiting in DD cases.
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yang dirawat di UPF Penyakit Anak RSUP Palembang selama
tahun 1989 [Thesis]. Palembang: Bagian IKA RSUP/FK
Unsri;1989.
3. Sunoto, Soeparto PSW, Soenarto Y, Ismail R. Buku ajar diare.
Jakarta: Dep Kes RI Ditjen PPM & PLP;1990. p. 1-164.
4. Thacker SB, Goodman RA. The management of acute
diarrhea in children: oral rehydration, maintenance and
nutritional therapy. Atlanta: Center for Disease Control and
Prevention; 1992. p. 41-60.
5. Brogden RN, Carmine A, Heel RC, Speight TM, Avery GS.
Domperidone. A review of its pharmacological activity,
pharmacokinetics a therapeutic efficacy in the symptomatic
treatment of chronic dyspepsia and as an antiemetic. Drugs
1992;24:360-400.
6. Kovac AL. Prevention and treatment post operative of
nausea and vomiting. Drugs 2000;59:213-43.
7. De Loore, Ravensteyn V, Ameryckx L. Domperidone in the
treatment of pediatric chronic vomiting and regurgitation:
A comparison with metoclopramide. Postgrad Med J
1979;55:40-2.
8. Bines JE, Quinlan JE, Treves S, Kleinman RE, Winter HS.
Efficacy of Domperidone in infants and children with
gastroesophageal reflux. J Pediatr Gastroenterol Nutr
1992;14:400-5.
9. WHO. A manual for the treatment of diarrhea. For use by
physicians and other senior health workers. Geneva: WHO;
1990.
10. Murphy M S. Guidelines for managing acute gastroenteritis
based on a systematic review of published research. Arch
Dis Child 1998;79:279-84.
11. Hirschhorn N. Oral rehydration therapy and early refeeding
in the management of childhood gastroenteritis. Can J Paed,
1994;1:160-4.
Published
2007-10-31
How to Cite
1.
O. I, Bakri A, Bahar E, Ismail R. Benefits of domperidone in ambulatory acute diarrhea with severe vomiting. PI [Internet]. 31Oct.2007 [cited 23Dec.2024];47(5):207-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/415
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Received 2016-09-01
Accepted 2016-09-01
Published 2007-10-31
Accepted 2016-09-01
Published 2007-10-31
