Risk factors influencing the outcomes in infants with epilepsy

Setyo Handryastuti; Irawan Mangunatmadja

doi:10.14238/pi47.5.2007.202-6

Setyo Handryastuti
Irawan Mangunatmadja

DOI: https://doi.org/10.14238/pi47.5.2007.202-6

Keywords: recurrent epileptic seizure, symptomatic epilepsy, risk factors

Abstract

Background Epilepsy in young children should always be
considered as a symptom of an underlying brain disease. Parents
and caregivers often asked whether the seizures can be controlled
and whether the epilepsy will affect the child development.
Objective To find out risk factors influencing the outcomes in
infants with epilepsy.
Methods This was a retrospective study on infants aged 1 month
until 12 months with recurrent epileptic seizures. We looked for
the risk factors as sex, types of medication, age at onset of seizure,
epilepsy syndrome, etiology of epilepsy, history of neonatal seizure,
first EEG features, and type of seizure for the last 6 month-period.
The outcomes evaluated were controlled seizure and developmental
status.
Results Hundred forty infants with epilepsy were reviewed,
consisted of 84 (60%) infants with symptomatic epilepsy, and 56
(40%) infants categorized as idiopathic. Forty-six (33%) infants
had controlled seizure, while 94 (67%) infants had uncontrolled
seizure. Abnormal developmental status was found in 75 infants
(54%). Abnormal developmental status was more found in infants
with polytherapy, age at onset of 1-4 months, symptomatic
epilepsy, positive remote symptomatic, history of neonatal seizure,
abnormality of first EEG, and uncontrolled seizure. Uncontrolled
seizure of epilepsy was more found in infants with polytherapy,
early age at onset (1-4 month old), symptomatic epilepsy, positive
remote symptomatic, history of neonatal seizure, and abnormality
of first EEG.
Conclusion Our data indicate that classifying syndrome of epilepsy
through diagnostic screening and age of onset are important to
determine the outcomes.

Author Biographies

Setyo Handryastuti

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Irawan Mangunatmadja

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

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