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considered as a symptom of an underlying brain disease. Parents
and caregivers often asked whether the seizures can be controlled
and whether the epilepsy will affect the child development.
Objective To find out risk factors influencing the outcomes in
infants with epilepsy.
Methods This was a retrospective study on infants aged 1 month
until 12 months with recurrent epileptic seizures. We looked for
the risk factors as sex, types of medication, age at onset of seizure,
epilepsy syndrome, etiology of epilepsy, history of neonatal seizure,
first EEG features, and type of seizure for the last 6 month-period.
The outcomes evaluated were controlled seizure and developmental
Results Hundred forty infants with epilepsy were reviewed,
consisted of 84 (60%) infants with symptomatic epilepsy, and 56
(40%) infants categorized as idiopathic. Forty-six (33%) infants
had controlled seizure, while 94 (67%) infants had uncontrolled
seizure. Abnormal developmental status was found in 75 infants
(54%). Abnormal developmental status was more found in infants
with polytherapy, age at onset of 1-4 months, symptomatic
epilepsy, positive remote symptomatic, history of neonatal seizure,
abnormality of first EEG, and uncontrolled seizure. Uncontrolled
seizure of epilepsy was more found in infants with polytherapy,
early age at onset (1-4 month old), symptomatic epilepsy, positive
remote symptomatic, history of neonatal seizure, and abnormality
of first EEG.
Conclusion Our data indicate that classifying syndrome of epilepsy
through diagnostic screening and age of onset are important to
determine the outcomes.
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2. Verity CM, Greenwood R, Golding J. Long-term intellectual
and behavioral outcomes of children with febrile convulsions.
N Eng J Med 1998;338:1723-8.
3. Vanderlinden L, Lagae LG. Clinical predictors for outcome
in infants with epilepsy. Pediatr Neurol 2003;31:52-5.
4. Shields WD. Catastrophic epilepsy in childhood. Epilepsia
5. Dulac OJ, Chiron C. Malignant epileptic encephalopaties in
children. Bailiries Clin Neurol 1996;5:765-81.
6. Kwong KL, Sung WY, Wong SN, So KT. Early predictors of
medical intractability in childhood epilepsy. Pediatr Neurol
7. Engel J Jr. A proposed diagnostic scheme for people with
epileptic seizures and with epilepsy: report of the ILAE Task
Force on Classification and Terminology. Epilepsia
8. Lado FA, Sankar R, Lowenstein D, Moshe SL. Age-
dependent consequences of seizures: Relationship to seizure
frequency, brain damage, and circulatory reorganization.
Ment Retard Dev Disabil Res Rev 2000;6:242-52.
9. Cavazzutti GB, Ferrari P, Lalla M. follow-up study of 482 cases
with convulsive disorders in the first year of life: Neurological
and cognitive outcome. Eur J Pediatr Neurol 1999;26:425-37.
10. Chevrie JJ, Aicardi J. Convulsive disorders in the first year of
life: Neurological and mental outcome and mortality.
11. Battaglia D, Rando T, Deodato F, Bruccini G, Baglio G,
Frisone MF, et al. Epileptic disorders with onset the first year
of life: Neurological and cognitive outcome. Eur J Paeditr