Interleukin-6 and highly sensitive C-reactive protein in obese adolescents

Michael Kasenda; Suryadi Tantura; Sarah Warouw

doi:10.14238/pi52.4.2012.219-22

Michael Kasenda Department of Child Health, Sam Ratulangi University Medical School, Manado
Suryadi Tantura Department of Child Health, Sam Ratulangi University Medical School, Manado
Sarah Warouw Department of Child Health, Sam Ratulangi University Medical School, Manado

DOI: https://doi.org/10.14238/pi52.4.2012.219-22

Keywords: interleukin-6, hsCRF, obesity, adolescents

Abstract

Background Childhood obesity is a major health concern.
Obesity is due to an expansion of adipose tissue mass. This tissue
produces proô€žinflarmnatory cytokines, such as interleukinô€ž6 (IL--6).
ILô€ž6 is considered to be the chief stimulator of the production of
highly sensitive Cô€žreactive protein (hsCRP) in the liver. Both
molecules are responsible for the chronic lowô€žgrade inflammatory
state in obese individuals.
Objective To assess a correlation between ILô€ž6 and hsCRP in
obese adolescents.
Methods This crossô€žsectional study was conducted from March
to June 2011 in Manado. Subjects were obese and normal body
mass index (BMI) teens aged 13ô€ž18 years. Serum glutamic
oxaloacetic transaminase (SOOT) and serum glutamic pyruvic
transaminase (SOPT) levels were measured to rule out liver
impairment. ILô€ž6 and hsCRP levels were also measured. Data was
analyzed by Pearson's correlation and linear regression to test for
correlation between IL--6 and hsCRP levels.
Results There was a strongly positive correlation between ILô€ž6
and hsCRP levels in obese adolescents (r=0.79 with P<O.OOl).
IL--6 and hsCRP levels were not significantly associated in subjects
with normal BMI.
Conclusions There was a strongly positive correlation between
IL--6 and hsCRP levels in obese adolescents, suggestive of an
ongoing, chronic, lowô€žgrade inflammatory state. [Paediatr
Indanes.2012;52:219-22].

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