Effect of probiotics supplementation on acute diarrhea in infants: a randomized double blind clinical trial

Main Article Content

I Gusti Ngurah Sanjaya Putra
Sudaryat Suraatmaja
I Ketut Nomor Aryasa

Abstract

Background Probiotics has advantages as a supplement for
management of infants with acute diarrhea. It influences the
duration of diarrhea by enhancing immune responses, elaborates
antimicrobial substances and occupies intestinal mucosal sites,
inhibits the attachment and the growth of pathogenic organisms
by achieving competitive exclusion and microbial balance.
Objective To assess the clinical effects of probiotics supplementation
on acute diarrhea in infants.
Methods This was a double blind, randomized clinical controlled
trial performed on infants aged 1-12 months old with acute
diarrhea, hospitalized in Sanglah Hospital, Denpasar. Subjects
were divided into two groups; the treatment group had standard
management with adjuvant probiotics, while the control group
received standard management with placebo.
Results From 70 infants enrolled in this study, the mean duration
of diarrhea in treatment group was significantly shorter than that
in the placebo group, 49.03 hours (SE 3.09) (95%CI 42.98;55.08)
vs 73.03 hours (SE 3.28) (95%CI 66.61;79.45); P=0.001.
Regarding failure of the treatment, probiotics supplementation
had relative risk reduction (RRR) of 67% and absolute risk
reduction (ARR) of 57%. In multivariate cox regression analysis
it was found that only probiotics supplementation influenced the
duration of acute diarrhea in infants.
Conclusion Probiotics can shorten the duration of acute diarrhea,
and is safe as an adjuvant to standard management for infants
with acute diarrhea.

Article Details

How to Cite
1.
Sanjaya Putra IG, Suraatmaja S, Aryasa IK. Effect of probiotics supplementation on acute diarrhea in infants: a randomized double blind clinical trial. PI [Internet]. 31Aug.2007 [cited 27Sep.2020];47(4):172-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/394
Section
Articles
Author Biographies

I Gusti Ngurah Sanjaya Putra

Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.

Sudaryat Suraatmaja

Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.

I Ketut Nomor Aryasa

Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.
Received 2016-08-30
Accepted 2016-08-30
Published 2007-08-31

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