Riboflavin as migraine prophylaxis in adolescents

  • Athaillah Athaillah Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Yazid Dimyati Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Johannes H. Saing Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Bistok Saing Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Hakimi Hakimi Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Aznan Lelo Department of Phannacology, University of North Sumatera Medical School/H. Adam Malik Hospital, Medan, North Sumatera
DOI: https://doi.org/10.14238/pi52.3.2012.132-7
Keywords: riboflavin, preventive, migraine, adolescents

Abstract

Background Migraine is a cause of recurrent headaches in
children. Riboflavin has been sho\Vll to be efficacious in preventing
migraine in adults. However, there has been little research on its
use in children and adolescents.
Objective To assess the effectiveness of riboflavin for migraine
prevention in adolescents.
Methods We conducted a randomized, doubleô€…blind, controlled
trial in the Islamic Centre of the Musthafav.iyah Mandailing Natal
District, North Sumatera, from May to July 2010. Adolescents
\\lith migraines, as defined criteria, were included. Subjects were divided into two groups,
receiving either 400 mg of riboflavin or placebo for 3 months.
Headache frequency was measured in headache days per month,
headache duration was measured in hours, and functional
disability was measured using the Pediatric Migraine Disability
Assessment Scale (PedMIDAS). Migraines were assessed before,
during and after intervention. Student's tô€…test was used for
statistical analysis.
Results A total of 98 patients, ranging from 12 to 19 years in
age (mean age 14.0 years) were enrolled. We found a significant
reduction in headache frequency in the second and third months.
Headache duration also differed significantly third months (P=0.012 and P=O.OOl, respectively). Riboflavin
decreased disability, as indicated by lower PedMIDAS scores in
the riboflavin group compared to the placebo group (26.1 and
34.3, respectively, P= 0.001).
Conclusion Riboflavin effectively decreased migraine frequency,
duration and disability in adolescents. [Paediatr Indones.
2012;52:132-7].

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Published
2012-06-30
How to Cite
1.
Athaillah A, Dimyati Y, Saing JH, Saing B, Hakimi H, Lelo A. Riboflavin as migraine prophylaxis in adolescents. PI [Internet]. 30Jun.2012 [cited 25Apr.2024];52(3):132-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/379
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Vol 52 No 3 (2012): May 2012
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Received 2016-08-30
Accepted 2016-08-30
Published 2012-06-30