Comparison of serial blood lactate level between dengue shock syndrome and dengue hemorrhagic fever (evaluation of prognostic value)

Main Article Content

M. Tatang Puspanjono
Abdul Latief
Alan R. Tumbelaka
Sudigdo Sastroasmoro
Hartono Gunardi

Abstract

Background Dengue shock syndrome (DSS) mortality is still high.
Monitoring of blood lactate level is important to evaluate shock.
Objectives The study were to review the difference between blood
lactate level of DSS and that of dengue hemorrhagic fever (DHF),
to correlate blood lactate level with hypoxia state as shock risk
factors (PaO 2 , oxygen saturation, and anion gap) and to determine
the cut-off point of blood lactate level to predict shock.
Methods The study was carried out at the Department of Child
Health, Medical School, University of Indonesia, Cipto
Mangunkusumo Hospital, Jakarta, from January until July 2006.
Three mL venous blood specimen was collected from all subjects
for peripheral blood, blood gasses, serology, and blood lactate
examinations. This study consisted of a retrospective cohort and
a cross sectional method. Data were analyzed with Chi-square
test. Continous data tested using Mann-Whitney method. To
know the correlation between blood lactate level and shock risk
factors we use logistic regression test.
Results In DSS group, 73% shows hyperlactatemia (lactate =2
mmol/L). Conversion of lactate means between two groups is
significantly different from day one to day two and three. There
was a negative correlation between lactate level and pO 2 and
oxygen saturation. Oxygen saturation is the only value that has
clinical correlation. Regressions analysis can be applied using Y
= 7.05–0.05 X equation. The cut-off point of lactate level as
marker for shock by using ROC curve is 32.015 mmol/L with 70%
sensitivity and 83.3% specificity.
Conclusions Hyperlactatemia in DSS can be considered as a sign
for unappropriate treatment of shock. Blood lactate level can be
used as a biochemical marker for tissue hypoxia, to assess severity
of the disease, as monitoring of treatment, and has prognostic
value of DHF cases.

Article Details

How to Cite
1.
Puspanjono M, Latief A, Tumbelaka A, Sastroasmoro S, Gunardi H. Comparison of serial blood lactate level between dengue shock syndrome and dengue hemorrhagic fever (evaluation of prognostic value). PI [Internet]. 31Aug.2007 [cited 30Sep.2020];47(4):150-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/367
Section
Articles
Author Biographies

M. Tatang Puspanjono

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Abdul Latief

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Alan R. Tumbelaka

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Sudigdo Sastroasmoro

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Hartono Gunardi

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.
Received 2016-08-28
Accepted 2016-08-28
Published 2007-08-31

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