Validity of protein-creatinine and protein-osmolality ratios in the estimation of massive proteinuria in children with nephrotic syndrome

Main Article Content

M. Sukmawati
K. Suarta

Abstract

Background Children with nephrotic syndrome have massive
proteinuria, a rate of excretion equal to or greater than 40 mg/
hour/m 2 body surface. The ability to quantitate massive urinary
protein excretion is very important for both diagnostic and
prognostic purposes. Quantification of proteinuria using 24-hour
urine collection (Esbach) is difficult to do especially in children;
moreover, many false-positive and false-negative results are
reported for any semi-quantitative methods such as dipstick and
sulfosalicylic acid measurement.
Objective To determine the accuracy of protein-creatinine ratio
(PCR) and protein-osmolality ratio (POR) in quantification of
massive proteinuria in children with nephrotic syndrome.
Methods Diagnostic tests were conducted on children with
nephrotic syndrome aged 2-12 years with Esbach as a reference
standard. Sensitivity, specificity, positive predictive value (PPV),
negative predictive value, (NPV), pre and posttest probability
were compared between PCR and POR.
Results Study patients consisted of 47 children, 38 (81%) with
massive proteinuria. PCR has sensitivity of 92%, specificity of
78%, PPV of 95%, NPV of 70% and posttest probability of 95%.
POR has sensitivity of 76%, specificity of 78%, PPV of 94%, NPV
of 44% and posttest probability of 94%.
Conclusion Both PCR and POR are accurate to determine massive
proteinuria in children with nephrotic syndrome.

Article Details

How to Cite
1.
Sukmawati M, Suarta K. Validity of protein-creatinine and protein-osmolality ratios in the estimation of massive proteinuria in children with nephrotic syndrome. PI [Internet]. 31Aug.2007 [cited 30Sep.2020];47(4):139-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/364
Section
Articles
Author Biographies

M. Sukmawati

Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.

K. Suarta

Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.
Received 2016-08-27
Accepted 2016-08-27
Published 2007-08-31

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