Efficacy of dexamethasone for lung maturity in preterm delivery in association with lamellar bodies count

  • Ni Made Sumiartini
  • Hendra Santoso
  • Wayan Retayasa
  • Made Kardana
Keywords: Preterm delivery, dexamethasone, lamellar bodies, lung maturity

Abstract

Background Organ immaturities in preterm infants may result in
perinatal death. One of the diseases is respiratory distress syndrome
(RDS) which is caused by lung immaturity. Dexamethasone is often
used to accelerate maturity of infant lungs.
Objective To determine the efficacy of dexamethasone on lung
maturity measured by lamellar bodies count.
Methods A quasi experimental study was done at Perinatology
Division, Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar. We recruited 72 subjects;
36 subjects were given four times intramuscular dexamethasone
5 mg every twelve hours before delivery. Thirty six subjects who
did not receive dexamethasone belonged to control group. Infants’
lungs maturity assessment was performed using lamellar bodies
count taken from amniontic fluid.
Results The gestational age ranged between 28 to 36 weeks, with
the mean gestational age in dexamethasone group was 32.2 (SD
1.76) weeks and that in control group was 31.7 (SD 2.65) weeks.
The efficacy of dexamethasone therapy on lung maturity was
significant with Fisher’s exact test P<0.0001, 95%CI 2.546;
11.173. Using multivariate logistic regression analysis, there was
significant correlation between dexamethasone and lung maturity
measured by lamellar bodies count [OR=239.39; P<0.0001,
95%CI 22.12;526.53].
Conclusion Administration of dexamethasone in pregnant
women during preterm delivery significantly improves lung
maturity measured by lamellar bodies count.

Author Biographies

Ni Made Sumiartini
Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali.
Hendra Santoso
Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.
Wayan Retayasa
Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.
Made Kardana
Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Bali, Indonesia.

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Published
2007-07-01
How to Cite
1.
Sumiartini N, Santoso H, Retayasa W, Kardana M. Efficacy of dexamethasone for lung maturity in preterm delivery in association with lamellar bodies count. PI [Internet]. 1Jul.2007 [cited 25Nov.2024];47(3):115-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/356
Section
Articles
Received 2016-08-25
Accepted 2016-08-25
Published 2007-07-01