Soy protein sensitization in cow’s milk allergy patients
Keywords:
cow’s milk allergy (CMA), soy protein sensitization, soy-specific IgE, food allergy, atopic diseases, extensive hydrolyzed formula
Abstract
Background The management of cow’s milk allergy (CMA) isavoidance of cow’s milk as strictly as possible. Extensive hydrolyzed
protein and amino acid based formulas are recommended dietary
products for treatment of CMA. However, they have some
disadvantages, such as bitter taste and high cost. Alternative
protein sources from vegetable proteins, such as soy, can be used
as milk-substitute. Previous studies showed the prevalence of soy
allergy in CMA patients in Western countries ranged between 0
to 63%, but the prevalence in Asia was not greater than 20% and
no data about this prevalence in Indonesia.
Objectives To determine the proportion of soy protein
sensitization in CMA patients and characteristics of CMA patients
who were sensitized to soy protein.
Methods Fifty seven CMA patients who consumed soy protein
were taken their blood sample to examine the soy-specific IgE.
Results From 57 CMA patients, we found only 18% of patients
who were sensitized to soy protein. Seven out of ten CMA patients
who were sensitized to soy protein were under 12 months old.
Atopic dermatitis was the most frequent clinical manifestation
(8/10) and all of them had family history of atopic diseases. Soy
sensitization in IgE-mediated and non-IgE mediated CMA were
6/10 and 4/10, respectively.
Conclusions Proportion of soy sensitization in CMA patients in
this study was 18%. Soy protein can be used as an alternative for
cow’s milk substitute in CMA patients.
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noglobulin E-mediated allergy to soy and peanuts. Pediatr
Allergy Immunol 2005;16:641-6.
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21. Magnolfi CF Zani G, Lacava L, Patria MF, Bardare M. Soy
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22. Giampietro PG, Ragno V, Daniele S, Cantani A, Ferrara M,
Businco L. Soy hypersensitivity in children with food allergy.
Ann Allergy 1992;69:143-6.
23. Ellman LK, Chatchateel P, Sicherer SH, Sampson HA. Food
hypersensitivity in two groups of children and young adults
with atopic dermatitis evaluated a decade apart. Pediatr Al-
lergy Immunol 2002:13;295–8.
Reed CE, Ellis EF, Adkinson NF, Yunginger JW, Busse WW,
editors. Allergy principles and pratice, volume II. 4 th edi-
tion. St.Louis: Mosby; 1993. p. 1661-86.
2. Siregar SP, Munasir Z. Pentingnya pencegahan dini dan tata
laksana alergi susu sapi. Sari Pediatri 2006;7:237-43.
3. Host A. Frequency of cow’s milk allergy in childhood. Ann
Allergy Asthma Immunol 2002;89:33-7.
4. Host A, Koletzko B, Dreborg S, Muraro A, Wahn U, Aggett P,
et al. Dietary products used in infants for treatment and pre-
vention of food allergy. Joint statement of the European Soci-
ety for Paediatric Allergology and Clinical Immunology
(ESPACI) Committee on Hypoallergenic Formulas and the
European Society for Paediatric Gastroenterology, Hepatology
and Nutrition (ESPGHAN) Committee on Nutrition. Arch
Dis Child 1999;81:80-4.
5. Businco L, Bruno G, Giampietro PG. Soy protein for the
prevention and treatment of children with cow-milk allergy.
Am J Clin Nutr 1998;68:1447S-52S.
6. Zeiger RS, Sampson HA, Bock SA, Burks AW, Harden K,
Noone S, et al. Soy allergy in infants and children with IgE-
associated cow’s milk allergy. J Pediatr 1999;134:614-22.
7. Quak SH, Tan SP. Use of soy-protein formula and soyfood
for feeding infants and children in Asia. Am J Clin Nutr
1998;68:1444S-6S.
8. Klemola T, Vanto T, Juntunen-Backman K, Kalimo K,
Korpela R, Varjonen E. Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow’s milk
allergy: a prospective randomized study with a follow-up to
the age of 2 years. J Pediatr 2002;140:219-24.
9. Klemola T, Kalimo K, Poussa T, Juntunen-Backman K,
Korpela R, Valovirta E, Vanto T. Feeding a soy formula to
children with cow’s milk allergy: the development of immu-
noglobulin E-mediated allergy to soy and peanuts. Pediatr
Allergy Immunol 2005;16:641-6.
10. Ahn KM, Han YS, Nam SY, Park HY, Shin MY, Lee SI. Preva-
lence of soy protein hypersensitivity in cow’s milk protein-
sensitive children in Korea. J Korean Med Sci 2003;18:473-
7.
11. Allergen data collection. Soybean (Glycine max). Internet
Symposium on Food Allergens 1999;1:51-79.
12. Harikul S, Haruehasavasin Y, Varavithya W, Chaicumpa W.
Cow milk protein allergy during the first year of life: a 12
year experience at the Children’s Hospital, Bangkok. Asian
Pac J Allergy Immunol 1995;13:107-11.
13. Ebisawa M, Ikematsu K, Imai T, Tachimoto H. Food allergy
in Japan. Allergy Clin Immunol Int 2003;15:214-7.
14. Pharmacia Diagnostics. Pharmacia CAP system spesific IgE
FEIA. Swedia: Pharmacia Diagnostics AB; 2004. p. 1-8.
15. Bischoff SC, Sellge G. Immune mechanisms in food-induced
disease. In: Metcalfe DD, Sampson HA, Simon RA, edi-
tors. Food allergy: adverse reactions to foods and food ad-
ditives. 3 rd edition. Massachusetts: Blackwell Publishing;
2003. p.14-37.
16. Committee on Nutrition American Academy of Pediatrics.
Soy protein-based formulas: recommendations for use in in-
fant feeding. Pediatrics 1998;101:148-53.
17. Rozenfeld P, Docena GH, Anon MC, Fossati CA. Detection
and identification of a soy protein component that cross-
reacts with caseins from cow’s milk. Clin Exp Immunol 2002;
130:49–58.
18. Nowak-Wegrzyn A, Sampson HA. Adverse reaction to food.
Med Clin N Am 2006;90:97-127.
19. Naspitz CK, Sole D, Jacob CA, Sarinho E, Soares FJP, Dantas
V. Sensitization to inhalant and food allergens in Brazilian
atopic children by in vitro total and specific IgE assay. Al-
lergy Project-PROAL. J Pediatr 2004;80:203-10.
20. Bruno G, Giampietro PG, Del Guercio MJ, Gallia P,
Giovannini L, Lovati C. Soy allergy is not common in atopic
children: a multicenter study. Pediatr Allergy Immunol
1997;8:190-3.
21. Magnolfi CF Zani G, Lacava L, Patria MF, Bardare M. Soy
allergy in atopic children. Ann Allergy Asthma Immunol
1996;77:197-201.
22. Giampietro PG, Ragno V, Daniele S, Cantani A, Ferrara M,
Businco L. Soy hypersensitivity in children with food allergy.
Ann Allergy 1992;69:143-6.
23. Ellman LK, Chatchateel P, Sicherer SH, Sampson HA. Food
hypersensitivity in two groups of children and young adults
with atopic dermatitis evaluated a decade apart. Pediatr Al-
lergy Immunol 2002:13;295–8.
Published
2007-05-01
How to Cite
1.
Muktiarti D, Munasir Z, Tumbelaka A. Soy protein sensitization in cow’s milk allergy patients. PI [Internet]. 1May2007 [cited 25Apr.2024];47(2):78-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/349
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Received 2016-08-25
Accepted 2016-08-25
Published 2007-05-01
Accepted 2016-08-25
Published 2007-05-01
