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development of childhood atopy is still controversy. Fever in the
first year of life which is frequently associated with infections might
Objective The aim of this study was to investigate the association
between fever in the first year of life and atopy in children.
Methods This was an observational clinical epidemiology study
performed at Puskesmas Garuda, Padasuka, and Babakan Sari,
Bandung, from January to March 2006. From 749 children, we
randomly chose 150 subjects each from group with and without
family history of atopic disease. Skin prick test and measurement
of total serum immunoglobulin (Ig) E were performed on each
children. Atopy was defined as the skin prick test result was
positive to >1 allergen. The number of fever episodes in the first
year of life was based on parents report. The relationship between
fever and atopy was analyzed using Mantel Haenszel.
Results From 284 subjects, atopy was found in 28.2% of children,
of which 32.4% with and 23.9% without a family history of atopic
disease. Generally there was no significant association between
fever and atopy. There was only decreased odds ratio with
increased fever episodes and trend analysis showed this decrease
was significant (P=0.01). The significant association between
fever and atopy were found only in group without family history
of atopic disease (P=0.03, OR=0.43, CI 95% 0.18;1.01).
Conclusion There is a relationship between fever and atopy in
children without family history of atopic disease.
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