Association of HLA class II and history of atopy and frequent relapse of childhood steroid-sensitive nephrotic syndrome
Abstract
Background The association between HLA class II and frequentrelapse of nephrotic syndrome (FRNS) has been reported.
Objective To identify the association between HLA class II,
history of atopy, and upper respiratory tract infection (URTI)
with FRNS.
Methods This was a case control study conducted at the
Department of Child Health, Hasan Sadikin Hospital Bandung
and Cipto Mangunkusumo Hospital Jakarta from November 2002
to October 2003 on children aged 1-14 years with FRNS. The
subjects consisted of 40 FRNS and 84 healthy children. HLA
class II was typed by polymerase chain reaction-sequence specific
oligonucleotide (PCR-SSO) in Leiden, the Netherlands. The
association between HLA class II and FRNS was expressed by
odds ratio (OR). The association between such factors and FRNS
was analyzed by logistic regression.
Results Atopy was higher in patients than that in controls
(P=0.013). URTI did not differ in both groups (P=0.173). HLA-
DRB1*03 and DRB1*04 (OR=4.43, P=0.03), DQB1*02
(OR=3.43, P=0.00), and DQB1*04 (OR=12.06, P=0.01) were
significantly higher among patients than those in controls whereas
HLA-DRB1*12 (OR=0.34, P=0.02) and DQB1*0301p
(OR=0.35, P=0.02) were significantly lower among patients than
those in controls. Using logistic regression analysis, only HLA-
DRB1*12, DQB1*02 and atopy took part in FRNS.
Conclusion HLA-DRB1*12, DQB1*02, and atopy all together
have association with FRNS.
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Accepted 2016-08-25
Published 2007-05-01