Association of HLA class II and history of atopy and frequent relapse of childhood steroid-sensitive nephrotic syndrome
Keywords:
Frequent relapsing nephrotic syndrome, risk factor, Malay ethnic, PCR-SSO
Abstract
Background The association between HLA class II and frequentrelapse of nephrotic syndrome (FRNS) has been reported.
Objective To identify the association between HLA class II,
history of atopy, and upper respiratory tract infection (URTI)
with FRNS.
Methods This was a case control study conducted at the
Department of Child Health, Hasan Sadikin Hospital Bandung
and Cipto Mangunkusumo Hospital Jakarta from November 2002
to October 2003 on children aged 1-14 years with FRNS. The
subjects consisted of 40 FRNS and 84 healthy children. HLA
class II was typed by polymerase chain reaction-sequence specific
oligonucleotide (PCR-SSO) in Leiden, the Netherlands. The
association between HLA class II and FRNS was expressed by
odds ratio (OR). The association between such factors and FRNS
was analyzed by logistic regression.
Results Atopy was higher in patients than that in controls
(P=0.013). URTI did not differ in both groups (P=0.173). HLA-
DRB1*03 and DRB1*04 (OR=4.43, P=0.03), DQB1*02
(OR=3.43, P=0.00), and DQB1*04 (OR=12.06, P=0.01) were
significantly higher among patients than those in controls whereas
HLA-DRB1*12 (OR=0.34, P=0.02) and DQB1*0301p
(OR=0.35, P=0.02) were significantly lower among patients than
those in controls. Using logistic regression analysis, only HLA-
DRB1*12, DQB1*02 and atopy took part in FRNS.
Conclusion HLA-DRB1*12, DQB1*02, and atopy all together
have association with FRNS.
References
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2. Konrad M, Mitilineos J, Bouissou F, Scherer S, Gulli MP,
Meissner I, et al. HLA class II associations with idiopathic
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Ohayon E, et al. Clinical implications from studies of HLA
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5. Haeffner A, Abbal M, Mytilineos J, Konrad M, Krammer I,
Bouissou F, et al. Oligotyping for HLA-DQA, DQB, and DPB
in idiopathic nephrotic syndrome. Pediatr Nephrol
1997;11:291–5.
6. Yap HK, Han EJS, Heng CK, Gong WK. Risk factors for
steroid dependency in children with idiopathic nephrotic
syndrome. Pediatr Nephrol 2001;16:1049-52.
7. Donia AF, Amer GM, Ahmed HA, Gazareen SH, Moustafa
FE, Shoeib AA, et al. Levamisole:adjunctive therapy in steroid
dependent minimal change nephrotic syndrome. Pediatr
Nephrol 2002;17:355–8.
8. Trompeter RS, Barratt TM, Kay R, Turner MW, Soothill
JF. HLA, atopy, and cyclophosphamide in steroid-
responsive childhood nephrotic syndrome. Kidney Int
1980;17:113–7.
9. Meadow SR, Sarsfield JK. Steroid-responsive nephrotic
syndrome and allergy: clinical studies. Arch dis Child
1981;56:509–16.
10. Kabuki N, Okugawa T. Influence of age at onset on the
outcome of steroid-sensitive nephrotic syndrome. Pediatr
Nephrol 1998;12:467–70.
11. Takeda A, Takimoto H, Mizusawa Y, Simoda M. Prediction
of subsequent relapse in children with steroid-sensitive
nephrotic syndrome. Pediatr Nephrol 2001;16:888–93.
12. Haycock GB. Steroid-responsive nephrotic syndrome. In:
Postlethwaite RJ, editor. Clinical pediatric nephrology.
Oxford: Butterworth-Heineman, 2003; p. 253–9.
13. Takeda A, Matsutani H, Niimura F, Ohgushi H. Risk factors
for relapse in childhood nephrotic syndrome. Pediatr Nephrol
1996;10:740–1.
14. Constantinescu AR, Shah HB, Foote EF, Pharm D, Weiss
LS. Predicting first year relapses in children with nephrotic
syndrome. Pediatrics 2000;105:492–5.
15. Konrad M, Mytilineos J, Ruder H, Opelsz G, Scharer K. HLA-
DR7 predicts the response to alkylating agents in steroid-
sensitive nephrotic syndrome. Pediatr Nephrol 1997;11:16–9.
identification of frequent relapsers among children with
minimal change nephrotic syndrome. J Pediatr 1978;
101:514–8.
2. Konrad M, Mitilineos J, Bouissou F, Scherer S, Gulli MP,
Meissner I, et al. HLA class II associations with idiopathic
nephrotic syndrome in children. Tissue Antigens 1994;
43:275–80.
3. Zhou GP, Guo YQ, Ji YH, Zhang GL. Major histocompatibility
complex class II antigen in steroid-sensitive nephrotic
syndrome in Chinese children. Pediatr Nephrol 1994;8:
140–1.
4. Bouissou F, Meissner I, Konrad M, Sommer E, Mytilineos J,
Ohayon E, et al. Clinical implications from studies of HLA
antigens in idiopathic nephrotic syndrome in children. Clin
Nephrol 1995;44:279–83.
5. Haeffner A, Abbal M, Mytilineos J, Konrad M, Krammer I,
Bouissou F, et al. Oligotyping for HLA-DQA, DQB, and DPB
in idiopathic nephrotic syndrome. Pediatr Nephrol
1997;11:291–5.
6. Yap HK, Han EJS, Heng CK, Gong WK. Risk factors for
steroid dependency in children with idiopathic nephrotic
syndrome. Pediatr Nephrol 2001;16:1049-52.
7. Donia AF, Amer GM, Ahmed HA, Gazareen SH, Moustafa
FE, Shoeib AA, et al. Levamisole:adjunctive therapy in steroid
dependent minimal change nephrotic syndrome. Pediatr
Nephrol 2002;17:355–8.
8. Trompeter RS, Barratt TM, Kay R, Turner MW, Soothill
JF. HLA, atopy, and cyclophosphamide in steroid-
responsive childhood nephrotic syndrome. Kidney Int
1980;17:113–7.
9. Meadow SR, Sarsfield JK. Steroid-responsive nephrotic
syndrome and allergy: clinical studies. Arch dis Child
1981;56:509–16.
10. Kabuki N, Okugawa T. Influence of age at onset on the
outcome of steroid-sensitive nephrotic syndrome. Pediatr
Nephrol 1998;12:467–70.
11. Takeda A, Takimoto H, Mizusawa Y, Simoda M. Prediction
of subsequent relapse in children with steroid-sensitive
nephrotic syndrome. Pediatr Nephrol 2001;16:888–93.
12. Haycock GB. Steroid-responsive nephrotic syndrome. In:
Postlethwaite RJ, editor. Clinical pediatric nephrology.
Oxford: Butterworth-Heineman, 2003; p. 253–9.
13. Takeda A, Matsutani H, Niimura F, Ohgushi H. Risk factors
for relapse in childhood nephrotic syndrome. Pediatr Nephrol
1996;10:740–1.
14. Constantinescu AR, Shah HB, Foote EF, Pharm D, Weiss
LS. Predicting first year relapses in children with nephrotic
syndrome. Pediatrics 2000;105:492–5.
15. Konrad M, Mytilineos J, Ruder H, Opelsz G, Scharer K. HLA-
DR7 predicts the response to alkylating agents in steroid-
sensitive nephrotic syndrome. Pediatr Nephrol 1997;11:16–9.
Published
2007-05-01
How to Cite
1.
Hilmanto D. Association of HLA class II and history of atopy and frequent relapse of childhood steroid-sensitive nephrotic syndrome. PI [Internet]. 1May2007 [cited 24Nov.2024];47(2):60-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/345
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Received 2016-08-25
Accepted 2016-08-25
Published 2007-05-01
Accepted 2016-08-25
Published 2007-05-01
