Potential risk factors of pediatric acute respiratory distress syndrome in sepsis

  • Kezia Theofani Saragih Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
  • Ririe Fachrina Malisie Department of Child Health, Medical Faculty of Universitas Sumatera Utara/Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia https://orcid.org/0000-0002-5579-7999
  • Rini Savitri Daulay Department of Child Health, Medical Faculty of Universitas Sumatera Utara/Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia https://orcid.org/0000-0002-0215-7955
  • Bobby Ramses Erguna Sitepu Department of Ophthamology, Medical Faculty of Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Keywords: ARDS; pediatric sepsis; risk factors

Abstract

Background Sepsis in children is characterized by a dysregulated host response to infection and life-threatening organ dysfunction. Pediatric acute respiratory distress syndrome (PARDS) is a severe complication of sepsis. Several known risk factors of PARDS are immunodeficiency, obesity, source of infection, and genetic factors.

Objective To describe the potential risk factors of PARDS in  septic children at Haji Adam Malik General Hospital, Medan, North Sumatera.

Methods This descriptive study using eligible medical record data from sepsis patients aged 1 month – 18 years was conducted at Haji Adam Malik General Hospital in 2020–2022. A total sampling method was used for subject selection. Patients’ demographic and clinical characteristics, mechanical ventilation modes and parameters, laboratory results, and outcomes were collected from medical records.  Patients were classified as having sepsis with PARDS if Pediatric Acute Lung Injury Consensus Conference (PALICC) criteria of ARDS was met.

Results Of 112 pediatric sepsis patients, 33.9% developed PARDS. The mortality rates for PARDS was 73.7%. Of the patients with PARDS, 57.9% had immunodeficiency, 60.5% patients had an intrapulmonary infection, 39.5% had an extrapulmonary infection, and 23.7% of patients had a suspected genetic disorder. In addition, 39.5% had good nutritional status, followed by 21.1% with obese.

Conclusion The majority of patients with PARDS have intrapulmonary infection and immunodeficiency. Some of patients with PARDS have suspected genetic disorders and well nourished.

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Published
2024-05-28
How to Cite
1.
Saragih K, Malisie R, Daulay R, Sitepu B. Potential risk factors of pediatric acute respiratory distress syndrome in sepsis. PI [Internet]. 28May2024 [cited 14Oct.2024];64(3):193-01. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3342
Section
Emergency & Pediatric Intensive Care
Received 2023-01-14
Accepted 2024-05-28
Published 2024-05-28