Comparison between COVID-19 and DHF co-disease with COVID-19 alone in two pediatric sibling patients
Keywords:
Corona virus, Dengue, Antibody, DENV, SARS-CoV-2
Abstract
We report herein the difference between Corona virus disease-19 (COVID-19) and dengue hemorrhagic fever (DHF) co-infection compared with COVID-19 alone in two pediatric sibling patients. This case report highlights a 10-year-old boy with both COVID-19 and DHF who had less severe coagulation disorder than his sister with COVID-19 alone. In a patient with a dual infection, the presence of dengue antibodies may induce immunological protection against COVID-19. We found reports of milder symptoms in patients who had dengue prior to SARS- CoV-2 infection; however, the opposite occured when SARS-CoV-2 infection precedes dengue.
References
1. Stubbs SCB, Blacklaws BA, Yohan B, Yudhaputri FA, Hayati RF, Schwem B, et al. Assessment of a multiplex PCR and nanopore-based method for dengue virus sequencing in Indonesia. Virol J. 2020;17:24. DOI: https://doi.org/10.1186/s12985-020- 1294-6
2. Nasomsong W, Luvira V, Phiboonbanakit D. Case report: dengue and COVID-19
coinfection in Thailand. Am J Trop Med Hyg. 2020;104:487-9. DOI: https://doi.org/10.4269/ajtmh.20-1340
3. Verduyn M, Allou N, Gazaille V, Andre M, Desroche T, Jaffar MC, et al. Co-infection of dengue and COVID-19: a case report. PloS Negl Trop Dis. 2020;14:e0008476. DOI: https://doi.org/10.1371/journal.pntd.0008476
4. Tatura SNN, Denis D, Santoso MS, Hayati RF, Kepel BJ, Yohan B, et al. Outbreak of severe dengue associated with DENV-3 in the city of Manado, North Sulawesi, Indonesia. Int J Infect Dis. 2021;106:185-96. DOI: https://doi.org/10.1016/j.ijid.2021.03.065
5. Bicudo N, Bicudo E, Costa JD, Castro J, Barra GB. Co-infection of SARS-CoV-2 and dengue virus: a clinical challenge. Braz J Infect Dis. 2020;24:452-4. DOI: https://doi.org/10.1016/j.bjid.2020.07.008
6. Nicolelis MA, Raimundo RL, Peixoto PS, de Andreazzi CS. How super-spreader cities, highways, hospital bed availability, and dengue fever influenced the COVID-19 https://doi.org/epidemic in Brazil. Sci Rep. 2021;11:13001. DOI: https://doi.org/10.1016/j.bjid.2020.07.008
7. Gupta B, Nehara H, Parmar S, Meena S, Gajraj S, Gupta J. Acute abdomen presentation in dengue fever during recent outbreak. J Acute Dis. 2017;6:198-204. DOI: https://doi.org/10.4103/2221-6189.219612
8. Weerakoon KGAD, Chandrasekaramb S, Jayabahu JPSNK, Gunasena S, Kularatne SAM. Acute abdominal pain in dengue haemorrhagic fever: a study in Sri Lanka, 2009. WHO Dengue Bull. 2009;33:70-4.
9. Mayor S. Covid-19: UK studies find gastrointestinal symptoms are common in children. BMJ. 2020;370:m3484. DOI: https://doi.org/10.1136/bmj.m3484.
10. Henry BM, de Oliveira MHS, Benoit J, Lippi G. Gastrointestinal symptoms associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis. Intern Emerg Med. 2020;15:857-9.
11. Vinayagam S, Sattu K. SARS-CoV-2 and coagulation disorders in different organs. Life Sci. 2020;260:118431. DOI: https://doi.org/10.1007/s11739-020-02329-9
12. Suresh VCS, Mukherjee S, Harne PS, Subedi A, Ganapathy MK, Patthipati VS, et al . Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19. BMJ Open Gastroenterol. 2020;7:e000417. DOI: https://doi.org/10.1136/bmjgast-2020-000417
13. Violi F, Pastori D, Cangemi R, Pignatelli P, Loffredo L. Hypercoagulation and antithrombotic treatment in coronavirus 2019: a new challenge. Thromb Haemost. 2020;120:949-56. DOI: https://doi.org/10.1055/s-0040-1710317
14. Yan G, Lee CK, Lam LTM, Yan B, Chua YX, Lim AYN, et al. Covert COVID-19 and false- positive dengue serology in Singapore. Lancet Infect Dis. 2020;20:536. DOI: 10.1016/S1473-3099(20)30158-4. Epub 2020 Mar 4. PMID: 32145189; PMCID: PMC7128937.
15. Nath H, Mallick A, Roy S, Sukla S, Basu K, De A, et al. Dengue antibodies can cross-react with SARS-CoV-2 and vice versa-antibody detection kits can give false-positive results for both viruses in regions where both COVID-19 and Dengue co-exist. J Med Microbiol. 2021;70:001369. DOI: https://doi.org/10.1099/jmm.0.001369
16. Silvestre OM, Costa LR, Lopes BVR, Barbosa MR, Botelho KKP, Albuquerque KLC, et al. Previous dengue infection and mortality in COVID-19. Clin Infect Dis. 2021;73: e1219– e1221. DOI: https://doi.org/10.1093/cid/ciaa1895.
17. Ulrich H, Pillat MM, Tárnok A. Dengue fever, COVID-19 (SARS-CoV-2), and antibody- dependent enhancement (ADE): a perspective. Cytometry A. 2020;97:662-7. DOI: https://doi.org/10.1002/cyto.a.24047
18. Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, et al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019;4:e123158. DOI: https://doi.org/10.1172/jci.insight.123158
19. Tan C, Li S, Liang Y, Chen M, Liu J. SARS-CoV-2 viremia may predict rapid deterioration of COVID-19 patients. Braz J Infect Dis. 2020;24:565-9. DOI: https://doi.org/10.1016/j.bjid.2020.08.010
20. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181:2-9. DOI: https://doi.org/10.1086/315215
21. Ricke DO. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. Front Immunol. 2021;12:640093. DOI: https://doi.org/10.3389/fimmu.2021.640093
22. Ajmeriya S, Kumar A, Karmakar S, Rana S, Singh H. Neutralizing antibodies and antibody-dependent enhancement in COVID-19: a perspective. J Indian Inst Sci. 2022;102(2): 671-687. DOI: https://doi.org/10.1007/s41745-021-00268-8
23. Alam A, Sudarwati S, Hakim DDL, Mahdiani S. Case report: severe COVID-19 and dengue in an Indonesian infant. Am J Trop Med Hyg. 2021;104:1456-60. DOI: https://doi.org/10.4269/ajtmh.20-1244
24. Tiwari L, Shekhar S, Bansal A, Kumar P. COVID-19 with dengue shock syndrome in a child: coinfection or cross-reactivity? BMJ Case Rep. 2020;13:e239315. DOI: 10.1136/bcr- 2020-239315.
25. Kazi MA, Ghosh S, Roychowdhury S, Giri PP, Sarkar M. A case study of dual infection of dengue and COVID-19: presenting as multiorgan dysfunction in an infant. J Trop Pediatr. 2020;67:fmaa080. DOI: https://doi.org/10.1093/tropej/fmaa080.
26. Somasetia DH, Malahayati TT, Andriyani FM, Setiabudi D, Nataprawira HM. A fatal course of multiple inflammatory syndrome in children coinfection with dengue. A case report from Indonesia. IDCases. 2020;22:e01002. DOI: https://doi.org/10.1016/j.idcr.2020.e01002
2. Nasomsong W, Luvira V, Phiboonbanakit D. Case report: dengue and COVID-19
coinfection in Thailand. Am J Trop Med Hyg. 2020;104:487-9. DOI: https://doi.org/10.4269/ajtmh.20-1340
3. Verduyn M, Allou N, Gazaille V, Andre M, Desroche T, Jaffar MC, et al. Co-infection of dengue and COVID-19: a case report. PloS Negl Trop Dis. 2020;14:e0008476. DOI: https://doi.org/10.1371/journal.pntd.0008476
4. Tatura SNN, Denis D, Santoso MS, Hayati RF, Kepel BJ, Yohan B, et al. Outbreak of severe dengue associated with DENV-3 in the city of Manado, North Sulawesi, Indonesia. Int J Infect Dis. 2021;106:185-96. DOI: https://doi.org/10.1016/j.ijid.2021.03.065
5. Bicudo N, Bicudo E, Costa JD, Castro J, Barra GB. Co-infection of SARS-CoV-2 and dengue virus: a clinical challenge. Braz J Infect Dis. 2020;24:452-4. DOI: https://doi.org/10.1016/j.bjid.2020.07.008
6. Nicolelis MA, Raimundo RL, Peixoto PS, de Andreazzi CS. How super-spreader cities, highways, hospital bed availability, and dengue fever influenced the COVID-19 https://doi.org/epidemic in Brazil. Sci Rep. 2021;11:13001. DOI: https://doi.org/10.1016/j.bjid.2020.07.008
7. Gupta B, Nehara H, Parmar S, Meena S, Gajraj S, Gupta J. Acute abdomen presentation in dengue fever during recent outbreak. J Acute Dis. 2017;6:198-204. DOI: https://doi.org/10.4103/2221-6189.219612
8. Weerakoon KGAD, Chandrasekaramb S, Jayabahu JPSNK, Gunasena S, Kularatne SAM. Acute abdominal pain in dengue haemorrhagic fever: a study in Sri Lanka, 2009. WHO Dengue Bull. 2009;33:70-4.
9. Mayor S. Covid-19: UK studies find gastrointestinal symptoms are common in children. BMJ. 2020;370:m3484. DOI: https://doi.org/10.1136/bmj.m3484.
10. Henry BM, de Oliveira MHS, Benoit J, Lippi G. Gastrointestinal symptoms associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis. Intern Emerg Med. 2020;15:857-9.
11. Vinayagam S, Sattu K. SARS-CoV-2 and coagulation disorders in different organs. Life Sci. 2020;260:118431. DOI: https://doi.org/10.1007/s11739-020-02329-9
12. Suresh VCS, Mukherjee S, Harne PS, Subedi A, Ganapathy MK, Patthipati VS, et al . Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19. BMJ Open Gastroenterol. 2020;7:e000417. DOI: https://doi.org/10.1136/bmjgast-2020-000417
13. Violi F, Pastori D, Cangemi R, Pignatelli P, Loffredo L. Hypercoagulation and antithrombotic treatment in coronavirus 2019: a new challenge. Thromb Haemost. 2020;120:949-56. DOI: https://doi.org/10.1055/s-0040-1710317
14. Yan G, Lee CK, Lam LTM, Yan B, Chua YX, Lim AYN, et al. Covert COVID-19 and false- positive dengue serology in Singapore. Lancet Infect Dis. 2020;20:536. DOI: 10.1016/S1473-3099(20)30158-4. Epub 2020 Mar 4. PMID: 32145189; PMCID: PMC7128937.
15. Nath H, Mallick A, Roy S, Sukla S, Basu K, De A, et al. Dengue antibodies can cross-react with SARS-CoV-2 and vice versa-antibody detection kits can give false-positive results for both viruses in regions where both COVID-19 and Dengue co-exist. J Med Microbiol. 2021;70:001369. DOI: https://doi.org/10.1099/jmm.0.001369
16. Silvestre OM, Costa LR, Lopes BVR, Barbosa MR, Botelho KKP, Albuquerque KLC, et al. Previous dengue infection and mortality in COVID-19. Clin Infect Dis. 2021;73: e1219– e1221. DOI: https://doi.org/10.1093/cid/ciaa1895.
17. Ulrich H, Pillat MM, Tárnok A. Dengue fever, COVID-19 (SARS-CoV-2), and antibody- dependent enhancement (ADE): a perspective. Cytometry A. 2020;97:662-7. DOI: https://doi.org/10.1002/cyto.a.24047
18. Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, et al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019;4:e123158. DOI: https://doi.org/10.1172/jci.insight.123158
19. Tan C, Li S, Liang Y, Chen M, Liu J. SARS-CoV-2 viremia may predict rapid deterioration of COVID-19 patients. Braz J Infect Dis. 2020;24:565-9. DOI: https://doi.org/10.1016/j.bjid.2020.08.010
20. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181:2-9. DOI: https://doi.org/10.1086/315215
21. Ricke DO. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. Front Immunol. 2021;12:640093. DOI: https://doi.org/10.3389/fimmu.2021.640093
22. Ajmeriya S, Kumar A, Karmakar S, Rana S, Singh H. Neutralizing antibodies and antibody-dependent enhancement in COVID-19: a perspective. J Indian Inst Sci. 2022;102(2): 671-687. DOI: https://doi.org/10.1007/s41745-021-00268-8
23. Alam A, Sudarwati S, Hakim DDL, Mahdiani S. Case report: severe COVID-19 and dengue in an Indonesian infant. Am J Trop Med Hyg. 2021;104:1456-60. DOI: https://doi.org/10.4269/ajtmh.20-1244
24. Tiwari L, Shekhar S, Bansal A, Kumar P. COVID-19 with dengue shock syndrome in a child: coinfection or cross-reactivity? BMJ Case Rep. 2020;13:e239315. DOI: 10.1136/bcr- 2020-239315.
25. Kazi MA, Ghosh S, Roychowdhury S, Giri PP, Sarkar M. A case study of dual infection of dengue and COVID-19: presenting as multiorgan dysfunction in an infant. J Trop Pediatr. 2020;67:fmaa080. DOI: https://doi.org/10.1093/tropej/fmaa080.
26. Somasetia DH, Malahayati TT, Andriyani FM, Setiabudi D, Nataprawira HM. A fatal course of multiple inflammatory syndrome in children coinfection with dengue. A case report from Indonesia. IDCases. 2020;22:e01002. DOI: https://doi.org/10.1016/j.idcr.2020.e01002
Published
2024-05-28
How to Cite
1.
Tatura S. Comparison between COVID-19 and DHF co-disease with COVID-19 alone in two pediatric sibling patients. PI [Internet]. 28May2024 [cited 3Jul.2024];64(3). Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3337
Section
Case Report
Copyright (c) 2024 Suryadi Nicolaas Napoleon Tatura
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Received 2023-01-11
Accepted 2024-05-28
Published 2024-05-28
Accepted 2024-05-28
Published 2024-05-28
