Effect of adding tyndallized probiotics to the World Health Organization standard therapy for acute diarrhea in children

  • Kesatrianita Mawarni Fanny the Department of Child Health, Medical School, Gadjah Mada University, Yogyakarta
  • Wahyu Damayanti the Department of Child Health, Medical School, Gadjah Mada University, Yogyakarta
  • Mohammad Juffrie the Department of Child Health, Medical School, Gadjah Mada University, Yogyakarta
Keywords: tyndallized probiotic, acute diarrhea, WHO standard therapy

Abstract

Background Diarrhea is the major cause of morbidity and mortality
in children. Probiotics can decrease the frequency and duration
of diarrhea. There are two types of probiotics, live and tyndallized.
Tyndallized probiotics have been stetilized, so they are unable to produce
active metabolites, but may have an effect on human immunity.
Objective To evaluate the effectiveness of supplementing WHO
standard therapy with tyndallized probiotics in children with
acute, watery diarrhea.
Methods We performed a randomized, single-blind, controlled
trial in children aged 3-60 months who were diagnosed with acute,
watery diarrhea at Gunungsitoh General Hospital, Nias, North
Sumatera. Subjects were collected by consecutive sampling by
way of parent interviews.
Results One hundred subjects with acute, watery diarrhea were
divided into 2 groups of 50. One group was treated with only
WHO standard therapy for acute, watery diarrhea. The other
group was treated by WHO standard therapy with the addition
of tyndallized probiotics. There were no significant differences in
basic characteristics between the two groups. Diarrheal duration
for the group receiving WHO standard therapy only was 3.95 ±
1.3 days, while that of the group receiving both WHO standard
therapy and tyndallized probiotics was 4.6 ± 2.3 days (P > 0.05).
Diarrheal frequency on the fifth day in the WHO standard therapy
group was 1.90 ± 0.99 times per day, while that of the tyndalhzed
probiotic group was 1.56 ± 0.67 times per day (P > 0.05).
Conclusion There were no significant differences between WHO
standard therapy alone and WHO standard therapy with the addition
of tyndallized probiotics for decreasing the duration and frequency of
diarrhea in children. [Paediatr lndones. 2012;52:91-4].

References

1. Juffrie M, Mulyani NS. Diare cair akut clan diare berdarah.
Jakarta: Badan Penerbit IDAI; 2009. p.1-14.
2. Badan penelitian clan pengembangan kesehatan-Depkes RI.
National Basic Health reaserch (Riskesdas) 2007. Jakarta:
National report; 2007. p.106-8.
3. Departemen Kesehatan RI. Policy of Health Minister
(Kepmenkes) ofRI (No.1216/Menkes/SK/XI/2001), guidelines
for the eradication of diarrheal diseases. Jakarta; 2005.
4. World Health Organization. The clinical management of
diarrhea: implementing the new recommendation. Geneva:
WHO Document Production Services; 2006. p. 2-5.
5. Van Niel CW, Feutdner C, Garisson MM, Christakis DA.
Lact obacillus therapy for acute infectious diarrhea in
children: a meta-analysis. Pediatrics. 2002;109:678-84.
6. Huang JS, Bousvaros A, Lee JW, Diaz A, Davidson EJ.
Efficacy of probiotics use in acute diarrhea in children: a
meta-analysis. Dig Dis Sci. 2002;47:2625-34.
7. Sjazewska H, Mrukowicz JZ. Probiotics in the treatment and
prevention ofacute infectious diarrhea in infants and children:
a systematic review of published randomized, double-blind,
placebo-controlled trials. J Pediatr Gastroenterol N utr.
2001;33:S l 7-25.
8. Ishibashi N, Yamazaki S. Probiotics and safety. Am J Clin
Nutt. 2001;73:8465-70.
9. Delcenserie V, Martel D, Lamoereux M, Amiot J, Boutin
Y, Roy D. lmmunomodularory effect of probiotics in the
intestinal tract. Curr Issues Mol Biol. 2008;10:37-54.
10. Khanna V, Alam S, Malik A, Malik A. Efficacy of tyndalized
Lactobacillus acidophilus in acute diarrhea. Indian} Pediatrics.
2005;72:935-8.
11. Pramono B, Sudarmo RM, Ran uh RG, Athiyah AF, Budiono.
Pengaruh pemberian heat-killed probiotic complex pada usia
6-24 bulan terhadap perjalanan clan kesembuhan diare akut
[master's thesis]. [Surabaya]: Universitas Airlangga; 2009.
12. Ribeiro H, Ribeiro TC, Mattos AP, Valois SS, Neri DA,
Vanderhoof JA, et al. Limitations of probiotic therapy in
acute, severe dehydrating diarrhea. J Pediatr Gastroenterol
Nutt. 2003;36:11 2-5 .
Published
2012-04-30
How to Cite
1.
Fanny K, Damayanti W, Juffrie M. Effect of adding tyndallized probiotics to the World Health Organization standard therapy for acute diarrhea in children. PI [Internet]. 30Apr.2012 [cited 29Mar.2024];52(2):91-4. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/325
Section
Articles
Received 2016-08-22
Accepted 2016-08-22
Published 2012-04-30