Superior mesenteric artery blood flow in infants of very preterm and very low birthweight and its related factors

  • Evita Karianni Bermanshah Ifran Pediatric Imaging Division, Departement of Child Health FKUI/RSCM
  • Wresti Indriatmi Department Dermatovenerology, Faculty of Medicine Universitas Indonesia
  • Tetty Yuniarti Department of Child Health, Faculty of Medicine Universitas Padjadjaran /Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
  • Nadjib Advani Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta
  • Saleha Sungkar
  • Dewi Irawati Soeria Santoso
  • Rinawati Rohsiswatmo
  • Yvan Vandenplas
  • Badriul Hegar Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta
Keywords: intestinal blood flow; superior mesenteric artery; very preterm infants


  1. Abstract

Background Significant hemodynamic changes in preterm infants during early life could have consequences, especially on the intestinal blood flow. Alteration of superior mesenteric artery (SMA) blood flow may lead to impairment in gut function and feeding intolerance.

Objectives To assess SMA blood flow velocity in very preterm and/or very low birth weight (VLBW) infants in early life and to elucidate the factors influencing them.

Methods This is a cross-sectional study conducted in NICU at Cipto Mangunkusumo Hospital, Jakarta. Superior mesenteric artery (SMA) blood flow was evaluated by peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) measurement using Color Doppler US at < 48 hours after birth. Maternal and neonatal data that could be potentially associated with SMA blood flow were obtained. Bivariate analyses were conducted with a P value of < 0.05 considered significant.

Results We examined 156 infants eligible for the study. PSV, EDV, and RI of SMA blood flow were not related to both gestational age and birth weight. Infant with small for gestational age (SGA) showed significantly lower EDV median [15.5 (range 0.0-32.8) vs 19.4 (range 0.0-113.0)] and higher RI [0.80 (range 0.58-1.00) vs 0.78 (range 0.50-1.00)] compared to appropriate for gestational age (AGA).  Infants born from mother with preeclampsia showed lower PSV median [(78.2 (range 32.0-163.0) vs 89.7 (range 29.2-357.0)]) and EDV [16.2 (range 0.0-48.5) vs 19.4 (range 0.0-113.0)] compared to without PE, while absent/reverse end-diastolic velocity (AREDV) revealed a lower EDV median [16.9 (range 0.0 – 32.4) vs 19.4 (range 0.0 – 113.0)] compared to no AREDV. Furthermore, infants with hs-PDA showed lower EDV median [16.2 (range 0.0-113.0) vs 19.4 (range 0.0-71.1)] but higher RI median [0.80 (range 0.50-1.00) vs 0.78 (range 0.55-1.00)] compared to non hs-PDA. No difference in SMA blood flow across other factors was observed.

Author Biography

Saleha Sungkar




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How to Cite
Ifran EK, Indriatmi W, Yuniarti T, Advani N, Sungkar S, Santoso DI, Rohsiswatmo R, Vandenplas Y, Hegar B. Superior mesenteric artery blood flow in infants of very preterm and very low birthweight and its related factors. PI [Internet]. 6Apr.2023 [cited 5Jun.2023];63(2):80-. Available from:
Pediatric Imaging
Received 2022-11-18
Accepted 2022-12-12
Published 2023-04-06