Pediatric logistic organ dysfunction score as a predictive tool of dengue shock syndrome outcomes
Keywords:
PELOD, shack, dengue haemnrrhagic fever
Abstract
Background The pediatric logistic organ dysfunction (PELOD)score is widely used as a predictive tool of patient outcomes
in pediatrics intensive care unit (PICU) settings, including
for dengue shock syndrome (DSS) patients. We evaluated the
predictive value of PELOD scores in DSS patients taken within
the first hours after PICU admission.
Objective To evaluate the usefulness of PELOD scores taken
in day 1 of PICU admission for predicting outcomes in DSS
patients.
Methods We included 81 DSS subjects admitted to the PICU
between April 2006 - October 2009 by consecutive sampling.
There were 12 children under 12 months of age, 48 children 1- 5
years of age, and 21 children above 5 years of age enrolled in the
study. PELOD calculations were performed as set out by original
articles, using the published formula.
Results0fthe81PICUpatients,15 (18.5%) died. The estimated,
predicted mortality using PELOD scores were 43% for infants
under 12 months, 12% for children 1 - 5 years, and 10% for
children above 5 years. The actual mortality rates were 58.3%
(7 subjects) for infants under 12 months, 10.4% (5 subjects) for
children 1-5 years, and 14.3% (3 subjects) for children above 5
years. In patients who died, PELOD indicated the most common
organ problems to be hepatic disorders (SGOT/SGPT > 950 IU!L)
and haematologic disorders (prothrombin time, INR > 1.65) in 8
(53.3%) subjects and 9 (60%) subjects, respectively.
Conclusion PELOD scores from subjects taken on day 1 of PICU
admission can be used to predict mortality outcome. [Paediatr
lndones. 2012;5 2: 72-7].
References
1. Han YY, Shanley TP. Multiple organ dysfunction syndrome.
In: Nichols DG, editor. Roger's textbook of pediatric intensive
care. 4th ed. Philadelphia: Lippincott Williams & Willkins;
2008. p. 292-4.
2. Leteurtre S, Duhamel A, Grandbastein B,Proulx F, Cotting
J, Gottesman R, et al. Daily estimation of the severity of
multiple organ dysfunction syndrome in critically ill children.
CMAJ. 2010;182:1181-7.
3. Wilkinson JD, Pollack MM, GlassNS,Kanter RK, Katz RW,
Steinhart CM. Mortality associated with multiple organ
system failure and sepsis in the pediatric intensive care unit.
J Pediatr. 1987;111:324-8.
4. Leteurtre S, Martinot A, Duhamel A, Gauvin F, Grandbastein
B, Nam TV, et al. Development of pediatric multiple organ
dysfunction score: use of two strategies. Med Decis Making.
l 999;19:339-410.
5. Lacroix J, Cotting J. Severity of illness and organ
dysfunction scoring in children. Pediatr Crit Care
Med. 2005;6:Sl26-34.
6. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastein
B, Cotting J, et al. Validation of pediatric logistic organ
dysfunction (PELOD) score: prospective, observational,
multicenter study. Lancet. 2003;362:192-7.
7. Dengue haemorrhagic fever: diagnosis, treatment, prevention
and control. 2nd edition. Geneva: World Health Organization.
1997:81-3.
8. Leteurtre S, Duhamel A, Grandbastein B, Lacroix J, Leclerc F.
Pediatric logistic organ dysfunction (PELOD) score. Lancet.
2006;367:900-2.
9. Proulx F, Joyal JS, Mariscalco MM, Leteurtre S,Leclerc F,
Lacroix J. The pediatric multiple organ dysfunction syndrome.
PediatrCrit Care Med. 2009;10:12-22.
10. Iskandar HR, Mulyo D, Praptiwi A, Suryatin Y. Comparison
between logistic organ dysfunction (PELOD) score and
pediatric risk of mortality (PRISM) III as a mortality
predictor in patients with dengue shock syndrome. Pediatrics.
2008;12l:Sl29.
11. Typpo KV, Petersen NJ, Hallman DM, Markovitz BP,
Mariscalco MM. Day one multiple organ dysfunction
syndrome is associated with poor functional outcome and
mortality in the pediatric intensive care unit. PediatrCrit
Care Med. 2009;10:562-70.
12. Lacroix], CottingJ. Severity ofillness and organ dysfunction
scoring in children. PediatrCrit Care Med. 2005 ;6:Sl26-34
13. Sin DD, Man SFP, Marrie TJ. PaC02: a marker of
severity in community acquired pneumonia. Am J Med.
2005; 118: 145-50.
14. Wiwanitkit V. Liver dysfunction in dengue infection, an
analysis of the previously published Thai cases. J Ayub Med
CollAbbottabad. 2007;19:10-2.
15. Wiwanitkit V, Manusvanich P. Can hematocrit and platelet
determination on admission predict shock in hospitalized
children with dengue hemorrhagic fever? A clinical
observation from a small outbreak. ClinApplThrombHemost.
2004; 10:65-7.
16. Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Ikeda T, et
al. Natural history of disseminated intravascular coagulation
diagnosed based on the newly established diagnostic criteria
for critically ill patients: results of a multicenter, prospective
survey. Crit Care Med. 2008;36: 145-51.
17. Qureshi AU. Comparison of three prognostic scores (PRISM,
PELOD and PIM 2) at pediatric intensive care unit under
Pakistani circumstances. J Ayub Med Coll Abbottabad.
2007;19:49-53.
In: Nichols DG, editor. Roger's textbook of pediatric intensive
care. 4th ed. Philadelphia: Lippincott Williams & Willkins;
2008. p. 292-4.
2. Leteurtre S, Duhamel A, Grandbastein B,Proulx F, Cotting
J, Gottesman R, et al. Daily estimation of the severity of
multiple organ dysfunction syndrome in critically ill children.
CMAJ. 2010;182:1181-7.
3. Wilkinson JD, Pollack MM, GlassNS,Kanter RK, Katz RW,
Steinhart CM. Mortality associated with multiple organ
system failure and sepsis in the pediatric intensive care unit.
J Pediatr. 1987;111:324-8.
4. Leteurtre S, Martinot A, Duhamel A, Gauvin F, Grandbastein
B, Nam TV, et al. Development of pediatric multiple organ
dysfunction score: use of two strategies. Med Decis Making.
l 999;19:339-410.
5. Lacroix J, Cotting J. Severity of illness and organ
dysfunction scoring in children. Pediatr Crit Care
Med. 2005;6:Sl26-34.
6. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastein
B, Cotting J, et al. Validation of pediatric logistic organ
dysfunction (PELOD) score: prospective, observational,
multicenter study. Lancet. 2003;362:192-7.
7. Dengue haemorrhagic fever: diagnosis, treatment, prevention
and control. 2nd edition. Geneva: World Health Organization.
1997:81-3.
8. Leteurtre S, Duhamel A, Grandbastein B, Lacroix J, Leclerc F.
Pediatric logistic organ dysfunction (PELOD) score. Lancet.
2006;367:900-2.
9. Proulx F, Joyal JS, Mariscalco MM, Leteurtre S,Leclerc F,
Lacroix J. The pediatric multiple organ dysfunction syndrome.
PediatrCrit Care Med. 2009;10:12-22.
10. Iskandar HR, Mulyo D, Praptiwi A, Suryatin Y. Comparison
between logistic organ dysfunction (PELOD) score and
pediatric risk of mortality (PRISM) III as a mortality
predictor in patients with dengue shock syndrome. Pediatrics.
2008;12l:Sl29.
11. Typpo KV, Petersen NJ, Hallman DM, Markovitz BP,
Mariscalco MM. Day one multiple organ dysfunction
syndrome is associated with poor functional outcome and
mortality in the pediatric intensive care unit. PediatrCrit
Care Med. 2009;10:562-70.
12. Lacroix], CottingJ. Severity ofillness and organ dysfunction
scoring in children. PediatrCrit Care Med. 2005 ;6:Sl26-34
13. Sin DD, Man SFP, Marrie TJ. PaC02: a marker of
severity in community acquired pneumonia. Am J Med.
2005; 118: 145-50.
14. Wiwanitkit V. Liver dysfunction in dengue infection, an
analysis of the previously published Thai cases. J Ayub Med
CollAbbottabad. 2007;19:10-2.
15. Wiwanitkit V, Manusvanich P. Can hematocrit and platelet
determination on admission predict shock in hospitalized
children with dengue hemorrhagic fever? A clinical
observation from a small outbreak. ClinApplThrombHemost.
2004; 10:65-7.
16. Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Ikeda T, et
al. Natural history of disseminated intravascular coagulation
diagnosed based on the newly established diagnostic criteria
for critically ill patients: results of a multicenter, prospective
survey. Crit Care Med. 2008;36: 145-51.
17. Qureshi AU. Comparison of three prognostic scores (PRISM,
PELOD and PIM 2) at pediatric intensive care unit under
Pakistani circumstances. J Ayub Med Coll Abbottabad.
2007;19:49-53.
Published
2012-04-30
How to Cite
1.
Dewi L, Nurfitri E. Pediatric logistic organ dysfunction score as a predictive tool of dengue shock syndrome outcomes. PI [Internet]. 30Apr.2012 [cited 20Apr.2024];52(2):72-7. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/322
Section
Articles
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Received 2016-08-22
Accepted 2016-08-22
Published 2012-04-30
Accepted 2016-08-22
Published 2012-04-30
