IgE-mediated soy protein sensitization in children with cow’s milk allergy
Keywords:
cow's milk allergy, immunoglobulin E-mediated sensitization to soy protein
Abstract
Background Soy-based formula as an alternative to cow's milkformula is preferable to extensively hydrolyzed protein formula
because of the lower cost and more acceptable taste. However,
cow's milk allergy patients can subsequently develop a sensitivity
to soy protein.
Objective To compare soy protein sensitization in children with
and without an allergy to cow's milk.
Methods This study was conducted in Yogyakarta from September
2007 until March 2008. Subjects were children aged below 4
years with an atopic history. Subjects were divided into 2 groups:
those with a positive skin prick test to cow's milk and those
with a negative skin prick test to cow's milk (control group).
Both groups were given soy formula and tested at 6 weeks for
sensitization to soy.
Results There were 45 children in each group. Age, sex, and
atopic history were similar in both groups. We found no soy
protein sensitization (negative skin prick results) in all subjects
from both groups.
Conclusion Risk of immunoglobulin E-mediated sensitization
to soy protein was not proven in children with cow's milk allergy.
[Paediatr lndones. 2012;52:67-71).
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Technol Res. 1999;5: 171-5.
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of milk protein hydrolysate formulae in children with cow's
milk allergy. Eur J Pediatr. 1993;152:760-2.
Churchill Livingstone; 2002.
2. Siregar SP, Munasir Z. Pentingnya pencegahan dini dan tata
laksana alergi susu sapi. Sari Pediatri. 2006;7:237-43.
3. Sampson HA. Food allergy. Part I: immunopathogenesis and
clinical disorders. J Allergy Clin Immunol. 1999;139:717-
28.
4. Indonesian Pediatrics Association. Konsensus IDAI tentang
tatalaksana alergi susu sapi. Jakarta: Badan Penerbit IDAI;
2010.
5. Indonesian Pediatrics Association. Alergi susu sapi. In:
Standar pelayanan medis kesehatan anak. 1st ed. Jakarta:
Badan Penerbit IDAI; 2004. p. 3-6.
6. Juffrie M. Alergi makanan. Yogyakarta: Gadjah Mada
University Press; 2003.
7. Seppo L, Korpela R, Lonnerdal B, Metsaniitty L, Backman
KJ, Klemola T. A follow-up of nutrient intake, nutritional
status, and growth in infants with cow milk allergy fed either
a soy formula or an extensively hydrolyzed whey formula. Am
J Clin Nutr. 2005;82:140-5.
8. Businco L, Bruno G, Giampietro PG. Soy protein for the
prevention and treatment of children with cow-milk allergy.
Am] Clin Nutr. 1998;68(suppl):l447S-52S.
9. Rozenfeld P, Docena GH, Anon MC, Fossati CA Detection
and identification of a soy protein component that crossreacts
with caseins from cow's milk. Clin Exp Immunol.
2002;130:49-58.
10. Zeiger RS, Sampson HA, Bock SA, Burks AW, Harden
K, Noone S. Soy allergy in infants and children with IgEassociated
cow's milk allergy. J Pediatr. l 999;134:614-22.
11. Ahn KM, Han YS, Nam SY, Park HY, Shin MY, Lee SI.
Prevalence of soy protein hypersensitivity in cow milk
protein-sensitive children in Korea. J Korean Med Sci.
2003;18:473-7.
12. Muktiarti D, Munasir Z, Tumbelaka AR. Sensitisasi terhadap
protein kedelai pada pasien alergi susu sapi. Proceedings of
the 3rd Pertemuan Ilmiah Tahunan (PIT) IDAI; 2007 May
7-9; Yogyakarta. Jakarta: Badan Penerbit IDAI; 2007.
13. Mclaughlan P, Anderson KJ, Coombs RRA. An oral
screening procedure to determine the sensitizing capacity of
infant feeding formulae. Clin Allergy. 1981; 11:311-8.
14. Villoslada FL, Olivares M, Jimenez J, Boza J, Xaus J. Goat
milk is less immunogenic than cow milk in a murine model
of atopy. J Pediatr Gastroenterol Nutt. 2004;39:354-60.
15. Vandenplas Y, Brueton M, Dupont C, Hill D, Isolauri
E, Koletzko S, et al. Guidelines for the diagnosis and
management of cow's milk protein allergy in infants. Arch
Dis Child 2007 ;92:902-8.
16. Wegrzyn AN, Sampson HA. Adverse reaction to food. Med
Clin N Am. 2006;90:97-127.
17. Ahmed T, Fuchs GJ. Gastrointestinal allergy to food: a review.
] Diarrhoeal Dis Res. 1997 ;15:211-23.
18. Madiyono M, Moeslichan S, Satroasmoro S, Budiman I,
Purwanto SH. Perkiraan besar sampel. In: Sastroasmoro S,
Ismael S, editors. Dasar-dasar metodologi penelitian klinis.
Jrded.Jakarta: Sagung Seto; 2010. p. 302-31.
19. Isolauri E, Kalliomaki M, Laitinen K, Salminen S. Modulation
of the maturing gut barrier and microbiota: a novel target in
allergic disease. Curr Pharmaceut Des. 2008;14:1368-75.
20. Mayer L. Mucosa! immunity. Pediatrics. 2003;111:1595-
1600.
21. Sampson HA. Update on food allergy: current reviews of
allergy and clinical immunology. J Allergy Clin Immunol.
2004; 113:805-19.
22. Eigenmann PA Mechanism of food allergy. Educational clinical
case series. Pediatr Allergy Immunol. 2009;20:5-ll.
23. H¢st A, Halken S, Jacobsen HP, Christensen AE, Herskind
AM, Flesner K. Clinical course of cow's milk protein allergy/
intolerance and atopic diseases in childhood. Pediatr Allergy
Immunol. 2002;13(Suppl):23-8.
24. Hill DJ, Firer MA, Shelton MJ, Hosking CS. Manifestations
of milk allergy in infancy: clinical and immunologic findings.
J Pediatr. 1986; 109:270-6.
25. Indonesian Bureau of Statistics. Perkembangan tingkat
konsumsi pangan secara nasional menurut wilayah dan jenis
pangan 1993-2002 [serial online]. c2003 [cited 2010 June
12]; Badan Pusat Statistik (BPS) Publication. Available from:
http: //www.bps.go.id
26. Ariani M. Penguatan ketahanan pangan daerah untuk
mendukung ketahanan pangan nasional. Pusat Analisis Sosial
Ekonomi dan Kebijakan Pertanian [serial on the internet]
c2010 [cited 2010 June 10]. Available from: http://pse.litbang.
deptan.go.id/ind/pdffiles/Nf.ono2 6-3. pdf
27. Darwin K. Nutritional implications of tempe in Indonesian
rural community. Proc Soc Exp Biol Med. 1969;131:579-83.
28. Mien KM. Penggunaan makanan bayi formula tempe
dalam diet bayi dan anak balita sebagai suatu daya upaya
penanggulangan masalah diare. [dissertation]. [Bogor]:
Institute Pertanian Bogor; 1987.
29. Soenarto SY, Sudigbia I, Herman, Karmini M, Darwin K.
Antidiarrheal characteristics of tempe produced traditionally
and industrially in children aged 6-24 months with acute
diarrhea. In: Soenarto SY, ed. Diarrhea case management:
using research findings directly for case management and teaching in a teaching hospital in Yogyakarta, Indonesia.
Yogyakarta: Gadjah Mada University Press; 1997. p. 99-
112
30. Tsumura K, Kugimiya W, Bando N, Hiemori M, Ogawa T.
Preparation of hypoallergenic soybean protein with processing
functionality by selective enzymatic hydrolysis. Food Sci
Technol Res. 1999;5: 171-5.
31. Guandalini S, N ocerino A. Soy protein intolerance. Medscape
[serial on the internet] c2005 [updated 2010 March 3; cited
2010 June 10]. Available from: http://emedicine.medscape.com/
article/932026-overview#aOl 99
32. Ragno V, Giampietro PG, Bruno G, Businco L. Allergenidty
of milk protein hydrolysate formulae in children with cow's
milk allergy. Eur J Pediatr. 1993;152:760-2.
Published
2012-04-30
How to Cite
1.
Santi A, Juffrie M, Sumadiono S. IgE-mediated soy protein sensitization in children with cow’s milk allergy. PI [Internet]. 30Apr.2012 [cited 23Dec.2024];52(2):67-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/321
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Received 2016-08-22
Accepted 2016-08-22
Published 2012-04-30
Accepted 2016-08-22
Published 2012-04-30
