Efficacy comparison of cetirizine and loratadine for allergic rhinitis in children

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Juliana Juliana
Rita Evalina
Lily Irsa
M. Sjabaroeddin Loebis


Background Allergic rhinitis represents a global health problem
affecting 10% to more than 40% of the population worldwide.
Several studies in recent years have described the efficacy of
second-generation antihistamines in younger children. It is
not well established whether cetirizine is more effective than
loratadine in reducing symptoms of allergic rhinitis.
Objective The objective of this study was to compare the efficacy
of loratadine with cetirizine for treatment of allergic rhinitis.
Methods We conducted a randomized, double-blind, controlled
trial of 100 children, aged 13 to 16 years, from October to
November 2009 at two junior high schools in Medan. Group
I received 10 mg of cetirizine and group II received 10 mg of
loratadine, each once daily in the morning for 14 days. Drug
efficacy was assessed by changes from baseline symptom scores
and evaluation of therapeutic responses after 3 days, 7 days and
14 days of treatment.
Results The efficacy of cetirizine compared to that of loratadine
was not statistically significant in diminishing nasal symptoms
after 3 days, 7 days and 14 days of treatment (P=0.40, P=0.07,
and P=0.057, respectively). Evaluation of side effects, however,
revealed significantly fewer headaches in the cetirizine group after
3 days and 7 days of treatment (P=0.01 and P=0.03, respectively)
than in the loratidine group. In addition, the loratadine group
had significantly more instances of palpitations after 7 days of
treatment (P=0.04) compared to the cetirizine group.
Conclusion There was no significant difference in cetirizine and
loratadine treatment effectiveness on allergic rhinitis. However,
loratadine was found to cause more headaches and palpitations
than cetirizine. [Paediatr lndones. 2012;52:61-6].

Article Details

How to Cite
Juliana J, Evalina R, Irsa L, Loebis M. Efficacy comparison of cetirizine and loratadine for allergic rhinitis in children. PI [Internet]. 30Apr.2012 [cited 15Aug.2020];52(2):61-6. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/320
Received 2016-08-22
Accepted 2016-08-22
Published 2012-04-30


1. Strachan D, Sibbald B, Weiland SL Worldwide variations
in prevalence of symptoms of allergic rhinoconjunctivitis
in children: The International Study of Asthma and
Allergies in Childhood (ISAAC). Pediatr Allergy Immunol.
1997;8: 161-76.
2. Melitzer EO. Evaluation of the optimal oral antihistamine
for patients with allergic rhinitis. Mayo Clinic Proc.
3. Thompson AK, Juniper E, Meltzer EO. Quality of life in
patients with allergic rhinitis. Ann Allergy Asthma Immunol.
4. Sienra-Monge JJ, Gazca-Aquilar A, Del Rio-Navarro B.
Double blind comparison of cetirizine and loratadine in
children ages 2 to 6 years with perennial allergic rhinitis. Am
J Ther. 1999;6:149-55
5. Buske LM. Pharmacokinetics/pharmacodynamics and
psychomotor performance aspects of antihistamine therapies.
Clin Appl Immunol. 2001;1:277-89.
6. Buck ML. The second-generation antihistamines in children.
[cited Oct 2010]; Available from: http: //www.healrhsystem.
virginia.edu/alive/pediatrics/PharmNews/200 I 04.pdf
7. Cantani A, Mocini V Antihistamines and the torsade
de point in children with allergic rhinitis. Eur Rev Med
Pharmacol Sci. 200;5: 139-42.
8. Conner SJ. Evaluation and treatment of the patient with
allergic rhinitis. J Fam Practice. 2002;5 :883-90
9. Ten-Eick AP, Blumer JL, Reed MD. Safety of antihistamines
in children. Drug Safety. 2001;24:119-47.
10. Mattila MJ, Paakkari I. Variations among non-sedating
antihistamines: are there real differences? Eur J Clin
Pharmacol. 1999;55:85-93.
11. Lee STS, Amin MJ. Efficacy and safety of loratadine
compared with astemizole in Malaysian patients with
allergic rhinitis. Sin Med J. 1994;35 :591-4.
12. Day JH, Briscoe M, Widlitz MD. Cetirizine, loratadine, or
placebo in subjects with seasonal allergic rhinitis: effects after
controlled ragweed pollen challenge in an environmental
exposure unit. J Allergy Clin Immunol. 1998; 101:638-45.
13. Olin BR. Drug facts and comparison. St. Louis: Facts and
Comparisons, Inc; 2001. p. 698-707.
14. Kremer B, Den-Hartog HM, Jolles J. Relationship
between allergic rhinitis, disturbed cognitive function
and psychological well being. Clin Exp Allergy. 2002;
15. Davila I, Sastre J, BartraJ, Cuvillo A, Jauregui L, Montoro J,
et al. Effect of antihistamines upon the cardiovascular system.
J Investig Allergy Clin Immunol. 2006;16: 13-23.