Combination of red cell distribution width and procalcitonin as diagnostic biomarkers of neonatal sepsis in preterm infants

  • Irene Ratridewi Infectious and Tropical Diseases Division, Department of Pediatrics, Universitas Brawijaya Medical School/Dr. Saiful Anwar Hospital, Malang, East Java http://orcid.org/0000-0002-9716-1673
  • Savitri Laksmi Winaputri Department of Child Health, Universitas Brawijaya Medical School/Dr. Saiful Anwar Hospital, Malang, East Java https://orcid.org/0000-0001-6808-3090
  • Eko Sulistijono Neonatology Division, Department of Pediatrics, Universitas Brawijaya Medical School/Dr. Saiful Anwar General Hospital, Malang, East Java
  • Brigitta I. R. V. Corebima Department of Pediatrics, Universitas Brawijaya Medical School/Dr. Saiful Anwar General Hospital, Malang, East Java
  • Achmad Yunus Department of Pediatrics, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia, Universitas Brawijaya Medical School/Dr. Saiful Anwar Hospital, Malang, East Java http://orcid.org/0000-0003-4676-5298
Keywords: neonatal sepsis, procalcitonin, red cell distribution width, diagnosis

Abstract

Background Diagnosis of neonatal sepsis is still challenging. Several diagnostics test have been developed to help diagnose of neonatal sepsis, but sometimes it could not be done routinely in limited facilities. Procalcitonin (PCT) and red cell distribution width (RDW) have been reported to have correlations with the risk of developing sepsis.

Objective To evaluate the diagnostic value of combined of PCT and RDW as markers for neonatal sepsis in preterm infants.

Methods A cross sectional study was conducted in the neonatal ward, Syaiful Anwar hospital, Malang, East Java. The subjects were preterm infants with neonatal sepsis. Blood culture were taken as the gold standard and RDW and PCT levels were assessed as the comparison. All of the test were performed at the begining of the study. The incidence of sepsis was reported as the main outcome. The data obtained were processed and analyzed using the receiver operating characteristic (ROC) method to obtain the area under curve (AUC) value.

Results Fifty-five preterm infants presenting neonatal sepsis were enrolled in this study. The combination of RDW and PCT showed AUC 0.814 (P=0.199) with sensitivity and specificity 78.9% and 80.6%, respectively in diagnosing neonatal sepsis compared to blood culture.

Conclusion Combination of RDW and PCT as markers of sepsis in preterm infants have good sensitivity and specificity.

Author Biography

Brigitta I. R. V. Corebima, Department of Pediatrics, Universitas Brawijaya Medical School/Dr. Saiful Anwar General Hospital, Malang, East Java



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Published
2023-03-16
How to Cite
1.
Ratridewi I, Winaputri S, Sulistijono E, Corebima B, Yunus A. Combination of red cell distribution width and procalcitonin as diagnostic biomarkers of neonatal sepsis in preterm infants. PI [Internet]. 16Mar.2023 [cited 28Mar.2024];63(1sup):29-4. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3189
Section
Infection & Tropical Pediatrics
Received 2022-09-27
Accepted 2023-03-16
Published 2023-03-16