Quality of life in children with chronic kidney disease

  • Ari Fibrianto FK UNSRI
  • Hertanti Indah Lestari Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital Palembang, South Sumatera
  • Yudianita Kesuma Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital Palembang, South Sumatera
  • Moretta Damayanti Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital Palembang, South Sumatera
  • Eka Intan Fitriana Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital Palembang, South Sumatera
  • Rismarini Rismarini Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital Palembang, South Sumatera
Keywords: : quality of life; CKD; children; risk factors

Abstract

Background Chronic kidney disease (CKD) has become a global burden on the healthcare system and significantly impacts the quality of life of children with the condition.

Objective To assess quality of life in children with CKD as well as its relationship with sociodemographic, medical, and psychosocial factors.

Methods This cross-sectional analytic study was conducted from June to November 2021 at Dr. Moh Hoesin Hospital, Palembang. Children with CKD aged 2–18 years were included by consecutive sampling. Parents and patients were asked to complete the PedsQL™ generic score scale version 4.0 questionnaire.

Results We assessed quality of life in 112 children with CKD from parents’ and children’s reports in the PedsQL™ questionnaire. Physical and emotional parameters had the lowest scores. Based on parental reports, quality of life was significantly associated with disease severity (P=0.002), behavioral disorders (P=0.007), and sleep disturbances (P=0.001). Based on the children’s reports, the factors significantly associated with quality of life were anemia (P=0.044), sleep disturbances (P=0.024), and behavioral disorders (P=0.002). Almost one-third of children with CKD had general impairment of quality of life, both from parental reports (32.1%) and children’s reports (33.0%).

Conclusion Disease severity, anemia, sleep disturbance, and behavioral disorders were all associated with poorer quality of life in children with CKD.

Author Biography

Moretta Damayanti, Department of Child Health, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital Palembang, South Sumatera

 

References

1. El Shafei AM, Hegazy IS, Fadel FI, Nagy EM. Assessment of quality of life among children with end-stage renal disease: a cross-sectional study. J Environ Public Health. 2018;2018:8565498. DOI: https://doi.org/10.1155/2018/8565498.
2. Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callagan AO, Lasserson DS, et al. Global prevalence of chronic kidney disease—a systematic review and meta-analysis. PLoS One. 2016;11:e0158765. DOI: https://doi.org/101.1371/journal.pone.0158765.
3. Assadi F. The epidemic of pediatric chronic kidney disease: the danger of skepticism. J Nephropathology. 2012; 1: 61-4. DOI: https://doi.org/10.5812/nephropathol.7445.
4. Ardissino G, Dacco V, Testa S, Bonaudo R, Claris-Appriani A, Taioli E, et al. Epidemiology of chronic renal failure in children: data from the ItalKid project. Pediatrics. 2003;111:e382-7. DOI: https://doi.org/10.1542/peds.111.4.e382.
5. Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI. Hasil Riset Kesehatan Dasar Tahun 2013. Jakarta: Kemenkes RI; 2013.
6. Pardede SO, Rafli A, Gunardi H. Quality of life in chronic kidney disease children using assessment Pediatric Quality of Life Inventory™. Saudi J Kidney Dis Transpl. 2019;30:812-18. DOI: https://doi.org/1319-2442.265456.
7. Kaspar CDW, Bholah R, Bunchman TE. A review of pediatric chronic kidney disease. Blood Purif. 2016;41:211–7. DOI: https://doi.org/10.1159/000441737.
8. Trifiro G, Sultana J, Giogianni F, Ingrasciotta Y, Buenmi M, Muscianisi M, et al. Chronic kidney disease requiring healthcare service: a new approach to evaluate epidemiology of renal disease. Biomed Res Int. 2014;2014:268362. DOI: https://doi.org/ 10.1155/2014/268362.
9. Boudreau JE, Dube A. Quality of life in end stage renal disease: a concept analysis. CANNT J. 2014;24:12–20. PMID: 24783768.
10. Spieth LE, Harris CV. Assessment of health-related quality of life in children and adolescents: an integrative review. J Pediatr Psychol. 1996;21:175-93. DOI: https://doi.org/ 10.1093/jpepsy/21.2.175.
11. Copelvitch L, Warady BA, Furth SL. Insight from the chronic kidney disease in children (CKiD) study. Clin J Am Soc Nephrol. 201l; 6:2047-53. DOI: https://doi.org/ 10.2215/CJN.10751210.
12. Tong A, Lowe A, Sainbury P, Craig JC. Experiences of parents who have children with chronic kidney disease: a systemic review of qualitative studies. Pediatrics. 2008;121:349-60. DOI: https://doi.org/ 10.1542/peds.2006-3470.
13. López CA, Escribano AF, Cantanero GG, Luque A, García EI. Calidad de vida percibida por niños con enfermedad renal crónica y por sus padres [Perceived quality of life in children with chronic renal disease and in their parents]. Nefrologia. 2010;30:103-9. Spanish. DOI: https://doi.org/10.3265/Nefrologia.pre2009.Dic.5683.
14. Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the di?erence?. Pharmacoeconomics. 2016;34:645–9. DOI: https://doi.org/ 10.1007/s40273-016-0389-9.
15. Dotis J, Pavlaki A, PrintzaA, Stabouli S, Antoniou S, Gkogka C, et al. Quality of life in children with chronic kidney disease. Pediatr Nephrol. 2016;31:2309–16. DOI: https://doi.org/ 10.1007/s00467-016-3457-7.
16. Gerson AC, Wentz A, Abraham AG, Mendley SR, Hooper SR, Butler RW, et al. Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics. 2010;125:e349-57. DOI: https://doi.org/ 10.1542/peds.2009-0085.
17. Varni JW, Burwinkle TM, Seid M. The PedsQL as a pediatric patient-reported outcome: reliability and validity of the PedsQL measurement model in 25.000 chidren. Expert Rev Pharmacoecon Outcomes Res 2005;5:705-19. DOI: https://doi.org/ 10.1586/14737167.5.6.705.
18. Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia Nomor 25 Tahun 2014 Tentang Upaya Kesehatan Anak. Jakarta: Kemenkes RI; 2014.
19. Morton MJS, Reynolds JM, Garralda ME, Postlethwaite RJ, Goh D. Psychiatric adjustment in end-stage renal disease: a follow up study of former pediatric patients. J Psychosom Res. 1994;38:293–303. DOI: https://doi.org/ 10.1016/0022-3999(94)90034-5.
20. Moreira JM, Soares CMBM, Teixeira AL,e Silva ACS, Kummer AM. Anxiety, depression, resilience and quality of life in children and adolescents with pre-dialysis chronic kidney disease. Pediatr Nephrol. 2015;30:2153-62. DOI: https://doi.org/ 10.1007/s00467-015-3159-6.
21. Didsbury MS, Kim S, Medway MM, Tong A, McTaggart SJ, Walker AM, et al. Socio-economic status and quality of life in children with chronic disease: a systematic review. J Paediatr Child Health. 2016;52:1062–9. DOI: https://doi.org/ 10.1111/jpc.13407.
22. Sitaresmi MN, Indraswari BW, Rozanti NM, Sabilatuttaqiyya Z, Wahab A. Health-related quality of life profle of Indonesian children and its determinants: a community-based study. BMC Pediatr. 2022;22:103. DOIhttps://doi.org/10.1186/s12887-022-03161-0.
23. Ary D, Jacobs LC, Sorensen C, Razavieh A.. Introduction to research in education. Belmont: Wadsworth Cengage Learning; 2010. ISBN-13: 978-0-495-60122-7
24. Clavé S, Tsimaratos M, Boucekine M, Ranchin B, Salomon R, Dunand O, et.al. Quality of life in adolescents with chronic kidney disease who initiate haemodialysis treatment. BMC Nephrol. 2019;20:163. DOI: https://doi.org/ 10.1186/s12882-019-1365-3.
25. Al-Uzri A, Matheson M, Gipson DS, Mendley SR, Hooper SR, Yadin O, et.al. The impact of short stature on health-related quality of life in children with chronic kidney disease. J Pediatr. 2013;163:736-41.e1. DOI: https://doi.org/ 10.1016/j.jpeds.2013.03.016.
26. Francis A, Didsbury MS, van Zwieten A, Chen K, James LJ, Kim S, et al. Quality of life of children and adolescents with chronic kidney disease: a cross-sectional study. Arch Dis Child. 2019;104:134-40. DOI: https://doi.org/10.1136/archdischild-2018-314934.
27. Ademola BL, Obiagwu PN, Aliyu A. Assessment of health-related quality of life of chronic kidney disease patients in aminu kano teaching hospital, Kano. Niger J Clin Pract. 2020;23:906-11. DOI: https://doi.org/ 10.4103/njcp.njcp_589_19.
28. Seikaly MG, Salhab N, Warady BA, Stablein D. Use of rhGH in children with chronic kidney disease: lessons from NAPRTCS. Pediatri Nephrol 2007;22:1195-204. DOI: https://doi.org/10.1007/s00467-007-0497-z.
29. Mendley SR, Spyropoulos F, Counts DR. Short stature e in chronic kidney disease treated with growth hormone and an aromatase inhibitor. Hindawi Publishing Corporation. Case Reports in Pediatrics. 2015;2015. Article ID 738571. DOI: https://doi.org/10.1155/2015/738571
30. Wua TCM., Langi FLFG, Kaunang WPJ. Kualitas hidup pasien hemodialisis di Unit Hemodialisis Rumah Sakit Umum Pusat Prof. Dr. R.D. Kandou Manado. Jurnal KESMAS. 2019;8:127-36.
31. Senduk CR, Palar S, Rotty LWA. Hubungan anemia dengan kualitas hidup pasien penyakit ginjal kronik yang sedang menjalani hemodialisis regular. e-CliniC. 2016;4:105-10. DOI: https://doi.org/10.35790/ecl.v4i1.10941.
32. Luo L, Chen Q. Effect of CKD–MBD phenotype on health-related quality of life in patients receiving maintenance hemodialysis: a cross sectional study. J Int Med Res.2020; 48: 0300060519895844. DOI: https://doi.org/ 10.1177/0300060519895844.
33. Ayoub A, Nelson K, Wood P, Hijjazi KH. The relationship between laboratory values and quality of life of dialysis patients in the United Arab Emirates. Renal Soc Australasia J. 2014;10:12-20.
34. Tjaden LA, Grootenhuis MA, Noordzij M, Groothoff JW. Health-related quality of life in patients with pediatric onset of end-stage renal disease: state of the art and recommendations for clinical practice. Pediatr Nephrol. 2016;31:1579–91. DOI: https://doi.org/ 10.1007/s00467-015-3186-3.
35. Karatas A, Canakci E, Turkmen E. Comparison of sleep quality and quality of life indexes with sociodemographic characteristics in patients with chronic kidney disease. Niger J Clin Pract. 2018;21:1461-7. DOI: https://doi.org/ 10.4103/njcp.njcp_146_18.
Published
2023-11-08
How to Cite
1.
Fibrianto A, Lestari H, Kesuma Y, Damayanti M, Fitriana E, Rismarini R. Quality of life in children with chronic kidney disease. PI [Internet]. 8Nov.2023 [cited 21Dec.2024];63(5):395-04. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3067
Section
Developmental Behavioral & Community Pediatrics
Received 2022-07-07
Accepted 2023-11-08
Published 2023-11-08