Correlation between C--reactive protein and serum iron levels in children with pneumonia

  • I Gd. Oki Novi Purnawan Department of Child Health, Medical School, Udayana University/Sanglah Hospital, Denpasar
  • Ida Bagus Subanada Department of Child Health, Medical School, Udayana University/Sanglah Hospital, Denpasar
  • Sri Mulatsih Department of Child Health, Medical School, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta
Keywords: CRP, serum iron, pneumonia

Abstract

Background Pneumonia is an infectious disease often occuring
in children under five years of age. At the time of infection,
pro-inflammatory cytokines are released. It is thought that these
pro-inflammatory cytokines cause changes to iron homeostasis
in the body.
Objective To determine a correlation between CRP and serum
iron levels in children with pneumonia.
Methods An analytical, cross-sectional study was performed
in children aged 6 months-5 years with severe pneumonia at
Sanglah Hospital, Denpasar, Bali from April-November 2010.
Laboratory examinations included CRP and serum iron levels.
The correlation between CRP and serum iron levels was analyzed
by Pearson's correlation.
Results From 69 children with severe pneumonia, 23 children
fulfilled the inclusion criteria. Subjects' median CRP level was
9.22 mg/Land median serum iron level was 25.55 ug/dL. The
coefficient correlation between CRP and serum iron levels was
-0.580 (P=0.004). The determination coefficient value was
0.316.
Conclusion In children with severe pneumonia, CRP level
correlates negatively with serum iron levels. [Paediatr lndones.
2012;52:38-42).

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Published
2012-03-30
How to Cite
1.
Purnawan IG, Subanada I, Mulatsih S. Correlation between C--reactive protein and serum iron levels in children with pneumonia. PI [Internet]. 30Mar.2012 [cited 29Mar.2024];52(1):38-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/297
Section
Articles
Received 2016-08-21
Accepted 2016-08-21
Published 2012-03-30