Correlation between C--reactive protein and serum iron levels in children with pneumonia
Keywords:
CRP, serum iron, pneumonia
Abstract
Background Pneumonia is an infectious disease often occuringin children under five years of age. At the time of infection,
pro-inflammatory cytokines are released. It is thought that these
pro-inflammatory cytokines cause changes to iron homeostasis
in the body.
Objective To determine a correlation between CRP and serum
iron levels in children with pneumonia.
Methods An analytical, cross-sectional study was performed
in children aged 6 months-5 years with severe pneumonia at
Sanglah Hospital, Denpasar, Bali from April-November 2010.
Laboratory examinations included CRP and serum iron levels.
The correlation between CRP and serum iron levels was analyzed
by Pearson's correlation.
Results From 69 children with severe pneumonia, 23 children
fulfilled the inclusion criteria. Subjects' median CRP level was
9.22 mg/Land median serum iron level was 25.55 ug/dL. The
coefficient correlation between CRP and serum iron levels was
-0.580 (P=0.004). The determination coefficient value was
0.316.
Conclusion In children with severe pneumonia, CRP level
correlates negatively with serum iron levels. [Paediatr lndones.
2012;52:38-42).
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et al. Contribution of C-reactive protein to the diagnosis
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pneumonia, for the community-acquired pneumonia. Chest.
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12. Gabay C, Kushner I. Acute phase protein and other systemic
responses to inflammation. N EnglJ Med. 1999;24:448-56.
13. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels
D. Time-course analysis of hepcidin, serum iron, and
plasma cytokine levels in humans injected with LPS. Blood.
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14. BrotanekJM, Gosz], Weitzman M, Flores G. Iron deficiency
in early childhood in the United States: risk factors and racial/
ethnic disparities. Pediatrics. 2007;120:568-75.
15. Rahman MA, Mannan MA, Rahman MH, Aretin KE, Azad
AK. Influence of acute respiratory infection on iron profile
in severely malnourished children. Mymensingh Med J.
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estimates of the causes of death in children. Lancet.
2005;365: 1147-52.
2. Walter T, Olivares M, Pizarro F, Munos C. Iron, anemia, and
infection. Nutt Rev. 1997;55:111-24.
3. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl
J Med. 2005;352:1011-23.
4. Kratz A, Lewandrowski EL. The plasma protein. In: Kenneth
DM, editor. Clinical laboratory medicine. 2nd ed. Philadelphia:
Lippincott Williams & Wilkins; 1997. p. 264-7.
5. Nastasijevic DB, Pejcic T, Radjenovic T, Radovic M. Inverse
correlation of CRP and serum iron in patients with simple
community-acquired pneumonia (CAP). Acta Fae Med
NAISS. 2006;24:107-12.
6. Luna CM. C-reactive protein in pneumonia: let me try again.
Chest. 2004;125:1192-5.
7. Melbye H. Point of care testing for C-reactive protein. J Fam
Physic. 2006;35 :313-5.
8. Lin CJ, Chen PY, Huang FL, Lee T, Chi CS, Lin CY.
Radiographic, clinical, and prognostic features of complicated
and uncomplicated community-acquired lobar pneumonia in
children. J Microbiol. 2006;39:489-95.
9. Farng KT, Wu KG, Lee YS, Lin YH, Hwang BT. Comparison
of clinical characteristics of adenovirus and non-adenovirus
pneumonia in children. J Microbiol Immunol Infect.
2002;35:37-41.
42 • Paediatr lndones, Vol. 52, No. 1, January 2012
10. Duga MK, Arora N, Prakash K, Jhamb R, Kumar N, Gupta
N. C-reactive protein in lower respiratory tract infection.
Lung India. 2005;22:41-4.
11. Almirall J, Bolibar I, Toran P, Pera G, Boquet X, Balanzo X,
et al. Contribution of C-reactive protein to the diagnosis
and assessment of severity of community-acquired
pneumonia, for the community-acquired pneumonia. Chest.
2004;125: 1335-42.
12. Gabay C, Kushner I. Acute phase protein and other systemic
responses to inflammation. N EnglJ Med. 1999;24:448-56.
13. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels
D. Time-course analysis of hepcidin, serum iron, and
plasma cytokine levels in humans injected with LPS. Blood.
2005; 106: 1864-6.
14. BrotanekJM, Gosz], Weitzman M, Flores G. Iron deficiency
in early childhood in the United States: risk factors and racial/
ethnic disparities. Pediatrics. 2007;120:568-75.
15. Rahman MA, Mannan MA, Rahman MH, Aretin KE, Azad
AK. Influence of acute respiratory infection on iron profile
in severely malnourished children. Mymensingh Med J.
2008; 17 :S52-8.
Published
2012-03-30
How to Cite
1.
Purnawan IG, Subanada I, Mulatsih S. Correlation between C--reactive protein and serum iron levels in children with pneumonia. PI [Internet]. 30Mar.2012 [cited 22Nov.2024];52(1):38-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/297
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Received 2016-08-21
Accepted 2016-08-21
Published 2012-03-30
Accepted 2016-08-21
Published 2012-03-30
