Case report of pseudomembranous colitis in a 3-year-old resulting from Clostridium difficile infection not associated with prior antibiotic therapy
Abstract
Pseudomembranous colitis (PMC) is a serious condition caused by Clostridium difficile, frequently arising after antimicrobial therapy. In recent years, Clostridium difficile infection rates have been rising and more younger patients have been affected than adult. This case report is about a 3-year-oldboy with clinical, laboratory, and endoscopic findings typical of pseudomembranous colitis, without a history of previous antibiotic therapy.
References
2. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66:e1-48. DOI: https://doi.org/10.1093/cid/cix1085
3. Collignon A, Ticchi L, Depitre C, Gaudelus J, Delmee M, Corthier G. Heterogeneity of Clostridium difficile isolates from infants. Eur J Pediatr. 1993;152:319-22. DOI: https://doi.org/10.1007/BF01956743?
4. Seekatz AM, Young VB. Clostridium difficile and the microbiota. J Clin Invest. 2014;124:4182-9. DOI: https://doi.org/10.1172/JCI72336
5. Tibesar E. Clostridium difficile infection in a very young infant with pseudomembranous colitis noted on endoscopy. Case Rep Gastroenterol. 2020;14:522-6. DOI: https://doi.org/10.1159/000508916
6. Borali E, De Giacomo C. Clostridium difficile infection in children: a review. J Pediatr Gastroenterol Nutr. 2016;63:e130-40. DOI: https://doi.org/10.1097/MPG.0000000000001264. ?
7. Cleary RK. Clostridium difficile-associated diarrhea and colitis: clinical manifestations, diagnosis, and treatment. Dis Colon Rectum. 1998;41:1435-49. DOI: https://doi.org/10.1007/BF02237064
8. Zwiener RJ, Belknap WM, Quan RI. Severe pseudomembranous enterocolitis in a child: case report and literature review. Pediatr Infect Dis J. 1989;8:876-82. DOI: https://doi.org/10.1097/00006454-198912000-00010
9. Sirakov I, Yordanov Y, Marinkov A, Trifonov I, Velev V, Tsaneva V. A case report of pseudomembranous colitis, not associated with prior antimicrobial drugs treatment. Trakia Journal of Sciences. 2019;17:259-63. DOI: https://doi.org/10.15547/tjs.2019.03.013
10. Brook I. Pseudomembranous colitis in children. J Gastroenterol Hepatol. 2005;20:182-6. DOI: https://doi.org/10.1111/j.1440-1746.2004.03466.x
11. Bartlett JG. Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organism. Clin Infect Dis. 1994;18 Suppl 4:S265-72. DOI: https://doi.org/10.1093/clinids/18.supplement_4.s265
Copyright (c) 2024 Lubana Akram, Md Wahiduzzaman Mazumder, Fahmida Begum, Nadira Musabbir, Md Nazmul Hassan
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Accepted 2024-05-28
Published 2024-05-28
