High Dosage Diazepam as Single Antispasmodic Agent in the Treatment of Neonatal Tetanus

  • Sugitha N. Department of Child Health, Universitas Udayana/Sanglah Hospital, Denpasar, Bali
  • Suwendra P. Department of Child Health, Universitas Udayana/Sanglah Hospital, Denpasar, Bali
  • Sudaryat Suraatmaja Department of Child Health, Universitas Udayana/Sanglah Hospital, Denpasar, Bali
DOI: https://doi.org/10.14238/pi23.9-10.1983.163-72
Keywords: neonatal tetanus, diazepam, antispasmodic

Abstract

An evaluation of diazepam as a single antispasmodic drug in the treatment of neonatal tetanus was made on 30 neonates, who were admitted to the Dept. of Child Health, General Hospital, Denpasar. Diazepam (Valium) was given with the dose of 2,5 mg intravenously at 2 hours intervals. It can be increased in very severe cases, to a maximal dose of 40 mg/kgbw/day.

The overall mortality of this study was 20%. Almost all deaths occurred within the first 5 days. Incubation period of less than 7 days, period of onset of less than 48 hours, age on admission of less than 5 days and spontaneous paroxysmal spasm were important factors to contribute to the high  mortality. The mortality also rose in proportion to the severity according to Patel and Joag criteria.

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Published
2021-12-21
How to Cite
1.
N. S, P. S, Suraatmaja S. High Dosage Diazepam as Single Antispasmodic Agent in the Treatment of Neonatal Tetanus. PI [Internet]. 21Dec.2021 [cited 25Apr.2024];23(9-10):163-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2903
Issue
Vol 23 No 9-10 (1983): September - October 1983
Section
Infection & Tropical Pediatrics

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Received 2021-12-21
Published 2021-12-21