Tinidazole versus Ornidazole in Amebic Dysentery in Children (a double blind trial)

  • Amer Panggabean Department of Child Health, Universitas Sumatera Utara Medical School/Dr. Pirngadi General Hospital, Medan, North Sumatera
  • Adi Sutjipto Department of Child Health, Universitas Sumatera Utara Medical School/Dr. Pirngadi General Hospital, Medan, North Sumatera
  • Dachrul Aldy Department of Child Health, Universitas Sumatera Utara Medical School/Dr. Pirngadi General Hospital, Medan, North Sumatera
  • A. H. Sutanto Department of Child Health, Universitas Sumatera Utara Medical School/Dr. Pirngadi General Hospital, Medan, North Sumatera
  • Helena Siregar Department of Child Health, Universitas Sumatera Utara Medical School/Dr. Pirngadi General Hospital, Medan, North Sumatera
Keywords: amebic dysentery, tinidazole, ornidazole, vomiting

Abstract

Between January and June 1978, a double blind trial was conducted in 3.5 children, suffering from  Amebic Dysentery in the OPD of the General Hospital Medan.

The children were treated ambulatory, either with Tinidazole or Ornidazole, with a dose of 50 mg/kg body weight/day for 3 consecutive days, under close supervision. All the children, except on in the Tinidazole group (case no. 20), gave excellent responses.

Disappearance of ameba's blood and mucus from the stools occurred in all of the patients after 2 days of treatment. There was no significant difference in the results of treatment with Tinidazole and Ornidazole (p>0.05). Side effects were minimal. Marked vomiting occurred in one patirnt of the Ornidazole group.

References

1. AHMED, T., ALI, F. and SARWAR S.G. : Clinical evaluation of Tinidazole in Amoebiasis in children. Arch. Dis. Child. 51 : 388 (1976).
2. YO KlAN TJAIJ ; RAID, N. and SUTANTO, A.H. : Flagyl (Metronidazole) in the treatment of Intestinal Amoebiasis. Part. I. Paediatr. Indones. 11 : 1 (1971a). Flagyl (Metronidazole) in the treatment of Intestinal Amoebiasis. Part II. J. Singapore Paediatr. Soc. 13 : 1 1971b).
3. YO KlAN TJAIJ, RAID, N. and SU TANTO A.H. : Flagyl (Metronidazole) in the treatment of Intestinal Amoebiasis. Part. II L Paediatr. Indones. 12 : 82 (1972).
4. LUBIS, Ch. P.; NAPITUPULU, A. RUSDIDJAS; SUTANTO, AH. dan SIREGAR H. : Tinidazole pada pengobatan Disenteri Amuba, Kumpulan Naskah Pertemuan Ilmiah Tahunan ke-V Badan Koordinasi Gastroenterologi Anak Indonesia (BKGAI) hal. 385 (1977).
5. TAMSU; SUDIGBIA, I; SUMANTRI AG.; TATY HENDARTO dan KAMILAH, B.R. : Pengobatan Amoebiasis dengan Tiberal. Kumpulan Naskah Pertemuan Ilmiah Tahunan ke-V Badan Koordinasi Gastroenterologi Anak Indonesia (BKGAI hal. 394 (1977) .
Published
2021-12-20
How to Cite
1.
Panggabean A, Sutjipto A, Aldy D, Sutanto AH, Siregar H. Tinidazole versus Ornidazole in Amebic Dysentery in Children (a double blind trial). PI [Internet]. 20Dec.2021 [cited 28May2024];20(11-12):229-5. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2886
Section
Pediatric Gastrohepatology
Received 2021-12-20
Published 2021-12-20