Developmental delay in 3-month-old low birth weight infants with hyperbilirubinemia
Keywords:
low birth weight infant, hyperbilirubinemia, developmental delay
Abstract
Backgrourui Developmental delay may be due to a variety offactors occurring during the prenatal, perinatal, or postnatal
periods, one of which is hyperbilirubinemia.
Objective To evaluate the impact ofhyperbilirubinemia on infant
developmental delay.
Methods A prospective cohort study was conducted from March to
July 2011. Subjects were low birth weight infants with and without
hyperbilirubinemia. Developmental delay was measured using the
Mullen Scales of Early Learning. Data was analyzed by Chi square
test and relative risks were calculated. Logistic regression analysis
was performed to assess factors associated with developmental
delay. Differences were considered statistically significant for P
values < 0.05.
Results Forty-six low birth weight infants were enrolled
in this study, 23 with hyperbilirubinemia and 23 without
hyperbilirubinemia. The relative risk (RR) for developmental
delay in the hyperbilirubinemia group was 2.08 (95%CI 0.51 to
8 .40). Multivariate analysis revealed that hyperbilirubinemia did
not significantly influence developmental delay (RR 1.45; 95%CI
0.29 to 7.31). However, small for gestational age with or without
hyperbilirubinemia significantly influenced developmental delay
(RR 12.13; 95%CI 2.43 to 60.56).
Conclusion Hyperbilirubinemia in low birth weight infants is
n ot a risk factor for developmental delay at the age of 3 months.
However, being small for gestational age with or without
hyperbilirubinemia significantly influences the likelihood of
developmental delay.
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2. Moeslichan, Surjono A, Suradi R, Rahardjani KB, Usman
A, Rinawati, et al. Tatalaksana ikterus neonatorum; 2004
[cited 2011 June 1). Available from: http://lontar.ui.ac.id/
opac/ui/.
3. Nathan JB. Penilaian perkembangan dalam pedoman klinis
pediatri.Jakarta: EGC; 2005.p.32-55.
4. Watchko JF, Oski FA Kernicterus in pre term newborns: Past,
present, and future. Pediatrics. 1992;90:707-15.
5. Watchko JF, Maisels MJ. Jaundice in low birthweight infants:
Pathobiology and outcome. Arch Dis Child Fetal Neonatal
Ed. 2003;88:455-8.
6. Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran 0,
Tekinalp G, er al. Incidence, course, and prediction of
hyperbilirubinemia in near-term and term newborns.
Pediatrics. 2004; 113: 77 5-80.
7. Gomella TL, Douglas M, Fabien GE. Management of the
extremely low birth weight infant during the first week of
life. In: Gomela TL, Cunningham D, Eyal FG, Zenk KE,
editors. Neonatology: Management, procedures, on call
problems, diseases, and drugs. New York: Lange Medical
Books/McGraw-Hill; 2004. p. 120-31.
8. Oh W, Tyson JE, Fanarof AA, Vohr BR, Perritt R, Stoll
BJ, et al. Association between peak serum bilirubin and
neurodevelopmental outcomes in extremely low birth weight
infants. Pediatrics. 2003; 112:773 -9.
9. Martin U. Icterus and hiperbilirubunemia in new born. In:
Nelson WE, Behrman RE, Kliegman RM, Jehnson HB,
editors. Nelson Texthbook of Pediatrics. 17th ed. Philadelphia:
WB Saunders Company; 2004. p. 610-6.
10. Rona! LP, Enrique MO. Hiperbilirubinemia pada neonatus
dalam penatalaksanaan neonatus risiko tinggi. Jakarta: EGC;
1998. p. 367-86.
11. Arimbawa IM, Soetjiningsih, Kari IK. Adverse effects of
hyperbilirubinemia on the development of healthy term
infants. Paediatr Indones. 2006;46:51-6.
12. Peryoga SU, Sukadi A, Wiradisuria S. The risk for delayed
development in low birth weight, appropriate for gestational
age pre term infants. Paediatr Indones. 2005;45: 154-9.
13. Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR,
Watchko JF. Hyperbilirubinemia in the newborn infant >
or = 35 weeks' gestation: An update with clarifications.
Pediatrics. 2009;124:1193-9.
14. Amin SB, Prinzing D, Myers G. Hyperbilirubinemia
and language delay in premature infants. Pediatrics.
2009;123:327 -31.
15. Croen LA, Yoshida CK, Odouli R, Newman TB. Neonatal
hyperbilirubinemia and risk of autism spectrum disorders.
Pediatrics. 2005;115:e135-8.
16. Bargen GA Realition ship between bilirubin and auditory
function in premature neonates [dissertation]. [Kansas
(KA)) : University of Kansas; 2009.
17. Saluja S, Agarwal A, Kier N, Amin S. Auditoryneuropathy
spectrum disorder in late pret erm and term infants
with severe jaundice. Int J Pediatr Otorhinolaryngol.
2010;74: 1292-7.
18. Ahlfors CE, Parker AE. Bilirubin binding contributes to the
increase in total bilirubin concentration in newborns with
jaundice. Pediatrics. 2010;126: 639-43.
Published
2013-08-31
How to Cite
1.
Wiradharma W, Windiani IG, Haksari E. Developmental delay in 3-month-old low birth weight infants with hyperbilirubinemia. PI [Internet]. 31Aug.2013 [cited 25Apr.2024];53(4):228-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/287
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Received 2016-08-21
Accepted 2016-08-21
Published 2013-08-31
Accepted 2016-08-21
Published 2013-08-31
