Prognostic factors of epilepsy in patients with neonatal seizures history
Keywords:
neonatal seizures, epilepsy, prognostic factors, hypoxic ischemic encephalopathy, epileptic state
Abstract
Background Seizures in neonates are often associated withneurological disorders in early life, including epilepsy. Several
possible prognostic factors may influence the development of
epilepsy in these patients.
Objective To evaluate prognostic factors that may influence the
occurrence of epilepsy in the first two years of life in patients with
a history of neonatal seizures.
Methods We performed a cohort retrospective study on patients
with neonatal se izures in Sardjito Hospital during 2004-2009.
Prognostic factors observed were gender, family history of
epilepsy, neonatal hypoglycemia, assisted labor, hypoxic ischemic
encephalopathy, preterm infant delivery, and epileptic state.
Results Hypoxic ischemic encephalopathy and epileptic state
increased the risk of epilepsy (HR 5.8; 95%CI 1.63 to 20.43 and
HR 6.3; 95%CI 2 .0 to 19. 70, respectively). Assisted labor, preterm
delivery, neonatal hypoglycemia, family history of epilepsy, and
gender did not increase the risk of epilepsy in the first two years
of life.
Conclusion Hypoxic ischemic encephalopathy and epileptic state
in neonates presenting with seizures are the prognostic factors to
be epileptic children during the first two years of life.
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2002;82:664-70.
2. Shorvon SD. Epidemiology, classification, natural history and
genetics of epilepsy. Lancet. 1990;336:93 -6.
3. Hauser WA, Annegers JF, Kurland LT. Prevalence of
epilepsy in Rochester, Minnesot a: 1940-1980. Epilepsia .
1991;336:291-5.
4. Passat J. Epidemiologi epilepsi. In: Soetomenggolo TS,
Ismael S, editors. Buku Ajar N eurologi Anak. 1st ed. Jakarta:
IDAI; 1999. p. 190-7.
5. Arzimanoglou A, Aicardi J. Seizure disorders of the neonate
and infant. Fetal and Neonatal Neurology. 2001;37:647-
51.
6. Legido A, Clancy RR, Berman PH. Neurologic outcome
after electroencephalographically proven neonatal seizures.
Pediatrics. 1991;88:583 -96.
7. Pisani F, Orsini M, Braibanti S, Copioli C, Sisti L, Turco EC.
Development of epilepsy in newborns with moderate hypoxicischemic
encephalopathy and neonatal seizures. Brain Dev.
2009;3 l:64-8.
8. Garfinkle J, Shevell ML Cerebral palsy, developmental
delay, and epilepsy after neonatal seizures. Pediatr Neurol.
2011;44:88-96.
9. Ronen GM, Buckly D, Penney S, Streiner DL. Long-term
prognosis in children with neonatal seizures: a populationbased
study. Neurology. 2007;69: 1816-22.
10. Glass HC, Hong KJ, Rogers EE, Jeremy RJ, Bonifacio SL,
Sullivan JE, et al. Risk factors for epilepsy in children with
neonatal encephalopathy. Pediatr Res. 2011;70:535-40.
11. Cavazos JE, Lum F, Spitz M. Seizure and epilepsy: an overview and classification. Med J. 2002;4: 1-11.
12. Nunes ML, Martins MP, Barea BM, Wainber RC, Costa
JC. Neurological outcome of newborns with neonatal
seizures: a cohort study in a tertiary university hospital. Arq
Neuropsiquaitr. 2008;66: 168-74.
13. WHO. Home visits for the newborn child: a strategy to
improve survival. Geneva: WHO Press; 2009. p. 1-8.
14. Pisani F, Cerminara C, Fusco C, Sisti L. Neonatal status
222 • Paediatr lndones, Vol. 53, No. 4, July 2013
epilepticus vs recurrent neonatal seizures: clinical findings
and outcome. Neurology. 2007;69:2177-85.
15. Garcias Da Silva LF, Nunes ML, DaCostaJC. Risk factors for
developing epilepsy after neonatal seizures. Pediatr Neurol.
2004;30:271-7.
16. Sarosa GI. Kejang dan spasme. In: Kosim M.S, Yunanto
A, Dewi R, Sarosa G.I, Usman A, editors. Buku Ajar
Neonatologi. l" ed. Jakarta: IDAI; 2008. p. 226-49.
Published
2013-08-31
How to Cite
1.
Sidiq B, Herini E, Wibowo T. Prognostic factors of epilepsy in patients with neonatal seizures history. PI [Internet]. 31Aug.2013 [cited 25Apr.2024];53(4):18-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/285
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Received 2016-08-21
Accepted 2016-08-21
Published 2013-08-31
Accepted 2016-08-21
Published 2013-08-31
