Hepatitis B antibody titers in Indonesian adolescents who received the primary hepatitis B vaccine during infancy

  • Hartono Gunardi Department of Child Health, University of Indonesia Medical School
  • Adra Firmansyah Department of Child Health, University of Indonesia Medical School
  • Sri Rezeki S Harun Department of Child Health, University of Indonesia Medical School
  • Sudigdo Sastroasmoro Department of Child Health, University of Indonesia Medical School
Keywords: adolescent, anti-HBs, booster, hepatitis B vaccine, immunity


Backgi-ound Hepatitis B (HB) has been classified as moderate-tohighly
endemic in Indonesia. HB vaccination, the most effective
method to prevent HB viral transmission, induces protective
antibodies against HB surface antigen (anti-HBs). However, these
antibodies decline in titer over time. Studies on the duration of
protection and the prevalence of n on-responders in Indonesian
adolescents have been limited.
Objectives To determine anti-HBs titers in 15-17-year old
Indonesian adolescents given primary HB vaccine during infancy
and the prevalence of non-responders after a HB vaccine booster
Methods This cross-sectional study was performed from February
to September 2008 on adolescents aged 15-17 years in three
senior high schools in Jakarta who received complete primary HB
vaccines during infancy, based on parents' recall. Investigations
included HB vaccination history, anthropometric measurements,
and blood tests for anti-HBs before and 4-6 weeks after a booster
dose ofHB vaccine.
Results Of 94 subjects, 35 had protective anti-HBs and 59 had
undetectable anti-HBs. A booster dose was administered to 5 8 of the
n on-protected subjects, of which 33 showed anamnestic responses.
However, 25 subjects failed to generate protective anti-HBs. Taking
into consideration the adolescents with protective anti-HBs before
and after the booster dose, serologic protection was demonstrated
in 73%. Non-responder prevalence was 27%. The high prevalence
of non-responders may indicate bias of parents' recall.
Conclusion Protective anti-HBs is detected in less than half of
Indonesian adolescents given primary HB vaccine during infancy.
Following booster dosage, anamnestic responses are n oted in onethird
of subjects. The prevalence of non-responders is 27%, but
confirmation with further study is needed.


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How to Cite
Gunardi H, Firmansyah A, Harun S, Sastroasmoro S. Hepatitis B antibody titers in Indonesian adolescents who received the primary hepatitis B vaccine during infancy. PI [Internet]. 30Jun.2013 [cited 16Jun.2024];53(3):160-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/274
Received 2016-08-21
Accepted 2016-08-21
Published 2013-06-30