Predictors of mortality in immunocompromised children with respiratory infections

  • Lea Sutrisna Universitas Gadjah Mada
  • Rina Triasih Department of Child Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Central Java
  • Ida Safitri Laksanawati Department of Child Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Central Java
Keywords: Mortality predictor, respiratory infection, immunocompromised

Abstract

Background Respiratory infection is a common morbidity and a major cause of mortality in immunocompromised children. Hence, identification of clinical parameters that predict mortality among immunocompromised children with respiratory infections is of importance to provide timely and appropriate intervention.

Objective To determine predictors of mortality in immunocompromised children with respiratory infections.

Methods We conducted a prospective cohort study of immunocompromised children aged 18 years or younger with respiratory tract infections who were admitted to Dr. Sardjito Hospital, Yogyakarta, Indonesia. All eligible children were prospectively followed up until hospital discharge. Clinical and laboratory parameters during the first 24 hours of hospitalization were collected.

Results Of 79 eligible children, the overall mortality was 11 subjects (13.9%). Fever, tachycardia, tachypnea, cyanosis, leukopenia, neutropenia, thrombocytopenia, and pleural effusion were predictive factors of mortality in bivariate analysis (P<0.25). A logistic regression model showed that neutropenia (absolute neutrophil count <125/mm3) and tachycardia were the best independent predictors of mortality in immunocompromised children with respiratory infections. The children with tachycardia had 15.8 times higher probability of mortality (95%CI 5.0 to 4.4) and those with neutropenia had 8.24 times higher probability of mortality. Cyanosis and pleural effusion were also independent mortality predictors.

Conclusion The risk of mortality is significantly increased in immunocompromised children with respiratory infection when tachycardia and neutropenia are also present.

Author Biography

Lea Sutrisna, Universitas Gadjah Mada
Child Health Department, Universitas Gadjah Mada

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Published
2022-07-27
How to Cite
1.
Sutrisna L, Triasih R, Laksanawati I. Predictors of mortality in immunocompromised children with respiratory infections. PI [Internet]. 27Jul.2022 [cited 25Sep.2022];62(4):237-2. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2649
Section
Pediatric Respirology
Received 2021-04-23
Accepted 2022-07-27
Published 2022-07-27