Hyperthyroid crisis with cholestasis in a 12-year-old girl: a case report

  • Celine Celine FK Unika Atma Jaya
  • Ni Made Dwiyathi Utami Karitas Hospital Southwest Sumba, Southwest Sumba, East Nusa Tenggara
DOI: https://doi.org/10.14238/pi63.2.2023.129-33
Keywords: : hyperthyroid crisis; cholestasis; children; case report

Abstract

Hyperthyroidism is considered to be an emergency in children. Death can occur in 10-20% of cases. This condition is found more often in adolescents and girls. Cholestasis may be caused by the hyperthyroidism or side effects of anti-thyroid drugs. Increased hepatic blood flow without adequate oxygen supply as a result of a hypermetabolic state affects the transport of bilirubin, leading to cholestasis.

References

1. John M, Sundrarajan R, Gomadam SS. Anti-thyroid drugs in pediatric Graves’ disease. Indian J Endocrinol Metab. 2015;19:340–6. DOI: https://doi.org/10.4103/2230-8210.152766.
2. Yati NP, Utari A. Diagnosis dan tata laksana hipertiroid. Jakarta: Ikatan Dokter Anak Indonesia; 2017. p. 19.
3. Regelmann MO, Miloh T, Arnon R, Morotti R, Kerkar N, Rapaport R. Graves’ disease presenting with severe cholestasis. Thyroid. 2012;22:437–9. DOI: https://doi.org/10.1089/thy.2011.0267.
4. Rivkees SA, Stephenson K, Dinauer C. Adverse events associated with methimazole therapy of Graves’ disease in children. Int J Pediatr Endocrinol. 2010;2010:176970. DOI: https://doi.org/10.1155/2010/176970.
5. Rivkees SA, Mattison DR. Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use. Int J Pediatr Endocrinol. 2009;2009:132041. DOI: https://doi.org/10.1155/2009/132041.
6. Santos JL, Choquette M, Bezerra JA. Cholestatic liver disease in children. Curr Gastroenterol Rep. 2010;12:30–9. DOI: https://doi.org/10.1007/s11894-009-0081-8.
7. Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid Off J Am Thyroid Assoc. 2016;26:1343–421. DOI: https://doi.org/10.1089/thy.2016.0229.
Published
2023-04-10
How to Cite
1.
Celine C, Utami NM. Hyperthyroid crisis with cholestasis in a 12-year-old girl: a case report. PI [Internet]. 10Apr.2023 [cited 23Apr.2024];63(2):129-3. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2633
Issue
Vol 63 No 2 (2023): March 2023
Section
Case Report

Copyright (c) 2023 Celine Celine

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Received 2021-03-23
Accepted 2023-04-10
Published 2023-04-10