Effect of lansoprazole on quality of life in adolescents with recurrent abdominal pain
Keywords:
Recurrent abdominal pain, quality of life, lansoprazole
Abstract
Background Recurrent abdominal pain (RAP) is one of the mostcommon complaints in adolescents. Treatment for RAP depends
on the etiology. Lansoprazole has been shown to be effective on
gastroesophageal reflux disease (GERD), but further study is
needed to assess the effects of lansoprazole on RAP.
Objective To assess quality of life (QoL) of RAP patients who
received lansoprazole compared to placebo treatment.
Methods This randomized, clinical trial was conducted in the
Secanggang District, Lan gkat Regency, North Sumatera, from
August to October 2009. Patients who met the Apley criteria for
RAP diagnosis were enrolled in the study. Subj ects were divided
into two groups: those who received 30 mg lansoprazole daily and
those who received placebo, for 14 days. Quality oflife was assessed
using the Pediatrics Quality of Life (PedsQL) version 4.0 before
administration oflansoprazole/placebo and reassessed 30 days after
treatment. Efficacy of treatment was assessed by comparing the
QoL before and after treatment in the two groups.
Results A total of 98 adolescents, aged 12 - 18 years, were
enrolled in the study and divided into two groups: lansoprazole
and placebo. There was no significant difference QoL in physical
health (mean differences 95%CI -109.19 to 1.02; P=0.054),
emotional health (mean differences 95%CI -29.26 to 45.48;
P=0.666), social functioning (mean differences 95%CI -42.91
to 31.69; P=0.766), and sch ool functioning (mean differences
95%CI -56.97 to 24.32; P= 0.430), before and after treatment
in the two groups.
Conclusion There is no significant difference in QoL between the
two groups of adolescents with RAP before and after lansoprazole
treatment.
References
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symptoms and stooling patterns do n ot drive diagnostic costs
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pain in urban early adolescents. J Pediatr Psycho!. 2006;3 l :582-96.
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testing. Pediatr Ann. 2009;38:259 -66.
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Headache Pain. 2006;7:322- 3.
16 . Peterson S, Hagglof BL, Bergstrom EI. Impaired health- related quality of life in children
with recurrent pain. Pediatrics. 2009; 124:e759-67.
17. Youssef NN, Murphy TG, Langseder AL, Rosh JR.Quality of
life for children with functional abdominal pain: a comparison study of patients' and parents'
perceptions. Pediatrics. 2006;117:54-9.
18. Walker LS. Helping the child with recurrent abdominal pain return to school. Pediatric Annal.
2004;33: 128-36.
19. Crushell E, Rowland M, Doherty M, Gormally S, Harty S, Bourke Billy, et al. Importance of
parental conceptual model of illness in severe recurrent abdominal pain. Pediatrics.
2003;112:1368-72.
20. Plunkett A, Beattie RM. Recurrent abdominal pain in childhood.] R Soc Med. 2005;98:101-6.
21. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Chronic
abdominal pain in children. Pediatrics. 2005 ;115:302-30.
22. Weydert JA, Ball TM, Davis MF. Systematic review of treatment for recurrent abdominal pain.
Pediatrics. 2003;1ll:el-l l.
23. Ball TM, Weydert JA. Methodological challenges to treatment trials for recurrent abdominal pain
in children. Arch Pediatr Adolesc Med. 2003; 157:1121-7.
24. Whitehead WE, Corazziari E, Prizont R. Definition of a responder in clinical trials for
functional gastrointestinal disorders: report on a symposium. Gut. 1999;45:II78-9.
25 . Richer JE, Campbell DR, Kahrilas PJ, Huang B, Fludas C. Lansoprazole compared with ranitidine
for the treatment of nonerosive gastroesophangeal reflux disease. Arch Intern Med. 2000;
160:1803-9.
26. Devanaraya NM, Rajindrajith S, Silva HJD. Recurrent abdominal pain in children. Indian Pediatr.
2009; 46:389- 99.
27. Sanders MR, Shepherd RW, Cleghorn G, Woolford H.
The treatment of recurrent abdominal pain in children: a controlled comparison of
cognitive-behavioral family intervention and standard pediatric care. J Consult Clin Psycho!.
2004;62:306- 14.
28. Drotar D, Palermo T. Commentary: conducting randomized controlled trial of psychological
treatment to improve the outcomes of recurrent abdominal pain: contributions and challenges.J
Pediatr Psycho!. 2005;30:449-53 .
29. Edwards MC, Mullins LL, Johnson], Bernardy N. Survey of pediatricians' management practices for
recurrent abdominal pain.J Pediatr Psycho!. 1994;19:241- 53 .
DK, Gartner JC, et al. Adult outcomes of pediatric recurrent
abdominal pain : do they just grow out of it? Pediatrics.
2001;108:1-7.
2. Jan icke DM, Finnev JW Empirically supported treatments
in pediatric psychology: recurrent abdominal pain. J Pediatr
Psycho!. 1999;24:115-27.
3. Lane MM, Weidler EM, Czyzewski DI, Shulman RJ. Pain
symptoms and stooling patterns do n ot drive diagnostic costs
for children with functional abdominal pain and irritable
bowel syndrome in primary or tertiary care . Pediatrics.
2009;123:758-64.
4. Venepalli NK , Van Tilburg MA, Whitehead WE. Recurrent abdominal pain: what determines medical
consulting behavior? Dig Dis Sci. 2006;51:192-201.
5. Berger MY, Gieteling MJ, Benninga MA. Chronic abdominal pain in children. BMJ.
2007;334:997-1002.
6. Chitkara DK, Rawat DJ, Talley NJ. The epidemiology of childhood recurrent abdominal pain in
western countries: a systematic review.Am J Gastroenterol. 2005; 100:1868-75.
7. Sopo SM, Radzik D, Calvani M. Does treatment with proton pump inhibitors for gastroesophageal
reflux disease (GERD) improve asthma and GERD? A systematic review. J Investig Allergol Clin
Immunol. 2009;19:1-5.
8. Varni]W, Seid M, Kurtin P. The PedsQL"" 4.0: Reliability and
validity of the Pediatric Quality of Life Inventory '" Version
4.0 generic core scales in healthy and patient populations. Med Care. 2001;39:800-12.
9. Malaty HM,Abudayyeh S, O'Malley KJ, Wilsey MJ, Fraley K, Gilger MA, et al. Development of a
multidimensional measure for recurrent abdominal pain in children: population-based studies in
three settings. Pediatrics. 2005; 115:e210-15.
10. White KS, Farrell AD. Anxiety and psychosocial stress as predictors of headache and abdominal
pain in urban early adolescents. J Pediatr Psycho!. 2006;3 l :582-96.
11. Aanpreung P. Suggestive parameters for eradication therapy in children with Helicobacter py
lori gastritis. J Med Assoc Thai. 2005 ;88:s2 l-6 .
12 . Levy RL. Cognitive behavior therapy for the treatment of recurrent abdominal pain. J Cogn
Psychother. 2005;19:137- 49.
13. Devanarayana NM, Hahenra DG.Recurrent abdominal pain syndrome in a cohort of Sri Lankan
children and adolescents. J Trop Pediatrics. 2008;54:178-83 .
14. Noe JD,LiBU. Navigatingrecurrent abdominalpain through clinical clues, red flags, and initial
testing. Pediatr Ann. 2009;38:259 -66.
15. Battistella PA, Toldo I.Headache and recurrent abdominal pains in preschool children. J
Headache Pain. 2006;7:322- 3.
16 . Peterson S, Hagglof BL, Bergstrom EI. Impaired health- related quality of life in children
with recurrent pain. Pediatrics. 2009; 124:e759-67.
17. Youssef NN, Murphy TG, Langseder AL, Rosh JR.Quality of
life for children with functional abdominal pain: a comparison study of patients' and parents'
perceptions. Pediatrics. 2006;117:54-9.
18. Walker LS. Helping the child with recurrent abdominal pain return to school. Pediatric Annal.
2004;33: 128-36.
19. Crushell E, Rowland M, Doherty M, Gormally S, Harty S, Bourke Billy, et al. Importance of
parental conceptual model of illness in severe recurrent abdominal pain. Pediatrics.
2003;112:1368-72.
20. Plunkett A, Beattie RM. Recurrent abdominal pain in childhood.] R Soc Med. 2005;98:101-6.
21. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Chronic
abdominal pain in children. Pediatrics. 2005 ;115:302-30.
22. Weydert JA, Ball TM, Davis MF. Systematic review of treatment for recurrent abdominal pain.
Pediatrics. 2003;1ll:el-l l.
23. Ball TM, Weydert JA. Methodological challenges to treatment trials for recurrent abdominal pain
in children. Arch Pediatr Adolesc Med. 2003; 157:1121-7.
24. Whitehead WE, Corazziari E, Prizont R. Definition of a responder in clinical trials for
functional gastrointestinal disorders: report on a symposium. Gut. 1999;45:II78-9.
25 . Richer JE, Campbell DR, Kahrilas PJ, Huang B, Fludas C. Lansoprazole compared with ranitidine
for the treatment of nonerosive gastroesophangeal reflux disease. Arch Intern Med. 2000;
160:1803-9.
26. Devanaraya NM, Rajindrajith S, Silva HJD. Recurrent abdominal pain in children. Indian Pediatr.
2009; 46:389- 99.
27. Sanders MR, Shepherd RW, Cleghorn G, Woolford H.
The treatment of recurrent abdominal pain in children: a controlled comparison of
cognitive-behavioral family intervention and standard pediatric care. J Consult Clin Psycho!.
2004;62:306- 14.
28. Drotar D, Palermo T. Commentary: conducting randomized controlled trial of psychological
treatment to improve the outcomes of recurrent abdominal pain: contributions and challenges.J
Pediatr Psycho!. 2005;30:449-53 .
29. Edwards MC, Mullins LL, Johnson], Bernardy N. Survey of pediatricians' management practices for
recurrent abdominal pain.J Pediatr Psycho!. 1994;19:241- 53 .
Published
2013-04-30
How to Cite
1.
Harahap S, Nafianti S, Sofyani S, Supriatmo S, Sinuhaji A. Effect of lansoprazole on quality of life in adolescents with recurrent abdominal pain. PI [Internet]. 30Apr.2013 [cited 25Nov.2024];53(2):99-03. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/261
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Received 2016-08-19
Accepted 2016-08-19
Published 2013-04-30
Accepted 2016-08-19
Published 2013-04-30
