Estimating glomerular filtration rate via cystatin C in preterm infants: a comparative analysis

  • Yesim Coskun Bahcesehir University School of Medicine Goztepe Medicalpark Hospital, Istanbul
  • Ozlem Unay Demirel Department of Clinical Biochemistry, Bahcesehir University School of Medicine Goztepe Medicalpark Hospital, Istambul
  • Tevfik Bayram Department of Public Health, Marmara University School of Medicine, Istambul
  • Ipek Akman Department of Pediatrics, Bahcesehir University School of Medicine Goztepe Medicalpark Hospital, Istambul
  • Duygu Ovunç Hacihamdioglu Department of Pediatrics, Bahcesehir University School of Medicine Goztepe Medicalpark Hospital, Istambul
Keywords: estimated glomerular filtration rate; preterm infants; serum creatinine; serum cystatin-C


Background: We aimed to determine the course of serum creatinine (sCr), serum cystatin C (sCysC) and urine cystatin C (uCysC) levels and calculate estimated glomerular filtration rate (eGFR) by using sCr- and sCysC-based formulas in preterm infants in the first 28 days of life.

Methods: A total of 52 neonates were included in this prospective study. According to gestational age (GA), the neonates were divided into three groups. Group 1 composed of neonates who were born ≤28 weeks (n=15), group 2 and 3 consisted of infants who were born 29-31 weeks (n=16) and 32-34 weeks (n=21), respectively. Blood and urine samples were obtained at the 24-48 hours of life and then weekly until 28th day of life. sCr- and sCysC-based formulas were applied to determine the value and course of eGFR.

Results: sCr level was negatively correlated with GA (r=-0.36, p=0.014) but not with BW (r=-0.15, p=0.31). While sCr levels showed significant variations in all study groups on day 7, day 14, and day 21 however, sCysC did not differ by GA at any time-points. All study groups had significantly different uCysC levels, except day 28. eGFR results calculated with sCr-based formula were detected to be closer to inulin.

Conclusion: In preterm infants, sCr seemed to be a more reliable marker than sCysC to calculate eGFR. Moreover, in the same population, uCysC levels may reflect renal maturation more than sCysC.


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How to Cite
Coskun Y, Demirel O, Bayram T, Akman I, Hacihamdioglu D. Estimating glomerular filtration rate via cystatin C in preterm infants: a comparative analysis. PI [Internet]. 25Jul.2022 [cited 25Sep.2022];62(4):223-1. Available from:
Received 2021-01-04
Accepted 2022-07-25
Published 2022-07-25