Insulin-like growth factor-1 and growth in infants 0-6 months of age
Abstract
Background During infancy, growth is affected by many factors, including hormones. Insulin-like growth factor-1 (IGF-1) is a hormone with an important role in regulating somatic growth and organ development.
Objective To analyze for possible correlations between IGF-1 levels and infant growth from 0-6 months of age.
Methods A prospective study was conducted on 38 infants from birth to 6 months of age. Inclusion criteria were full-term newborns with normal birth weight and singleton birth. Serum IGF-1 was measured twice, from umbilical cord blood at birth and at 6 months of age. Anthropometric measurements were made every three months. Paired T-test was used to analyze mean IGF-1 among time points, and Pearson’s correlation test was used to analyze IGF-1 levels and growth.
Results Mean IGF-1 level decreased from birth to 6 months of age (89.6 ng/mL vs. 48.3 ng/mL, respectively; P<0.001). Delta IGF-1 had positive significant correlations with delta weight at 3 months (r=0.347; P=0.033) and 6 months (r=0.386; P=0.017), as well as delta head circumference at 3 months (r= 0.356; P=0.028) and 6 months (r=0.357; P=0.028). However, there were significant negative correlations between umbilical cord IGF-1 with delta body weight (r= −0.459; P=0.004) and delta length at 6 months (r= −0.414; P=0.010).
Conclusions. There iss a decrease in IGF-1 levels at the first 6 months of life. Umbilical cord IGF-1 level has negative correlations with the weight and length increment at the age of 6 months.
References
2. Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L. Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. Acta Paediatr. 2005;94:531-7. DOI: 10.1111/j.1651-2227.2005.tb01934.x
3. Chellakooty M, Juul A, Boisen KA, Damgaard IN, Kai CM, Schmidt IM, et al. A prospective study of serum 
insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding. J Clin Endocrinol Metab. 2006; 91:820-6. DOI: 10.1210/jc.2005-0950
4. Yuksel B, Ozbek MN, Mungan NO, Darendeliler f, Budan B, Bidaci A, et al. Serum IGF-1 and IGFBP-3 levels in healthy children between 0 and 6 years of age. J Clin Res Pediatr Endocrinol. 2011;3:84-8. DOI: 10.4274/jcrpe.v3i2.17
5. WHO Department of Nutrition for Health and Development. WHO Child Growth Standard. Geneva : WHO Press; 2006.
6. Javaid MK, Godfrey KM, Taylor P, Shore SR, Breier B, Arden NK, et al. Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition. J Bone Miner Res. 2004;19:56-63. DOI: 10.1359/JBMR.0301211
7. Kouanda S, Tonglet R, De Coninck V, Doulougou B, Sondo B, Ketelslegers JM, et al. Reference values of IGF-1 in children from birth to 5 years of age, in Burkina Faso, using blood samples on filter paper. Growth Horm IGF Res. 2008:18:345-52. DOI: 10.1016/j.ghir.2008.01.008
8. Mennella JA, Ventura AK, Beauchamp GK. Differential growth patterns among healthy infants fed protein hydrolysate or cow-milk formulas. Pediatrics. 2011;127:110-8. DOI: 10.1542/peds.2010-1675
9. Madsen AL, Larnkjaer A, Molgaard C, Michaelsen KF. IGF-1 and IGFBP-3 in healthy 9 month old infants from the SKOT cohort: breastfeeding, diet, and later obesity. Growth Horm IGF Res. 2011;21:199-204. DOI: 10.1016/j.ghir.2011.05.003
10. Rzehak P, Grote V, Lattka E, Weber M, Gruszfeld D, Socha P, et al. Associations of IGF-1 gene variants and milk protein intake with IGF-I concentrations in infants at age 6 months. Results from a randomized clinical trial. Growth Horm IGF Res.2013;23:149-58. DOI : 10.1016/j.ghir.2013.05.002
11. Puche JE, Cortazar IC. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012;10:1-29. DOI: 10.1186/1479-5876-10-224
12. Wang X, Xing KH, Qi J, Guan Y, Zhang J. Analysis of the relationship of insulin-like growth factor-1 to the growth velocity and feeding of healthy infants. Growth Horm IGF Res. 2013;23:215-9. DOI: 10.1016/j.ghir.2013.08.001
13. Livingstone C. Insulin-like growth factor-I (IGF-I) and clinical nutrition. Clin Sci. 2013;125:265-80. DOI: 10.1042/CS20120663
14. Gunnell D, Miller LL, Rogers I, Holly JM, ALSPAC Study Team. Association of insulin-like growth factor I and insulin-like growth factor-binding protein-3 with intelegence quotient among 8- to 9-year-old children in the Avon Longitudinal Study of Parents and Children. Pediatrics. 2005;116:681-6. DOI: 10.1542/peds.2004-2390
15. Wiley AS, Joshi SM, Lubree HG, Bhat DS, Memane NS, Raut DA, et al. IGF-I and IGFBP-3 concentrations at 2 years: associations with anthropometry and milk consumption in an Indian cohort. Eur J Clin Nutr. 2018;72:564-71. DOI: 10.1038/s41430-018-0108-z
16. Jansson N, Nilsfelt A, Gellerstedt M, Wennergren M, Rossander-Hulthén L, Powell TL, et al. Maternal hormones linking maternal body mass index and dietary intake to birth weight. Am J Clin Nutr. 2008;87:1743–9. DOI: 10.1093/ajcn/87.6.1743
17. de Jong M, Cranendonk A, Twisk JW, van Weissenbruch MM. IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infants. PLoS One. 2017;12:e0171650. DOI: 10.1371/journal.pone.0171650
18. Rossenfeld RG. Insulin-like growth factors and the basis of growth. N Engl J Med. 2003;349:2184-6. DOI: 10.1056/NEJMp038156
19. Putet G, Labaune JM, Mace K, Steenhout P, Grathwohl D, Raverot V, et al. Effect of dietary protein on plasma insulin-like growth factor-1, growth, body composition in healthy term infants: a randomized, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study). Br J Nutr. 2016:115:271-84. DOI: 10.1017/S0007114515004456
20. Monzavi R, Cohen P. IGFs and IGFBPs: role in health and disease. Best Pract Res Clin Endocrinol Metab. 2002;16:433-47. DOI: 10.1053/beem.2002.0212
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Accepted 2021-03-16
Published 2021-03-16
