Insulin-like growth factor-1 and growth in infants 0-6 months of age

  • Maria Mexitalia Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Bob Kevin Pardede Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital Semarang, Central Java
  • Agustini Utari Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Maria Mexitalia Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
Keywords: umbilical cord IGF-1, IGF-1 at 6 months of age, growth


Background During infancy, growth is affected by many factors, including hormones. Insulin-like growth factor-1 (IGF-1) is a hormone with an important role in regulating somatic growth and organ development.

Objective To analyze for possible correlations between IGF-1 levels and infant growth from 0-6 months of age.

Methods A prospective study was conducted on 38 infants from birth to 6 months of age. Inclusion criteria were full-term newborns with normal birth weight and singleton birth. Serum IGF-1 was measured twice, from umbilical cord blood at birth and at 6 months of age. Anthropometric measurements were made every three months. Paired T-test was used to analyze mean IGF-1 among time points, and Pearson’s correlation test was used to analyze IGF-1 levels and growth.

Results Mean IGF-1 level decreased from birth to 6 months of age (89.6 ng/mL vs. 48.3 ng/mL, respectively; P<0.001). Delta IGF-1 had positive significant correlations with delta weight at 3 months (r=0.347; P=0.033) and 6 months (r=0.386; P=0.017), as well as delta head circumference at 3 months (r= 0.356; P=0.028) and 6 months (r=0.357; P=0.028). However, there were significant negative correlations between umbilical cord IGF-1 with delta body weight (r= −0.459; P=0.004) and delta length at 6 months (r= −0.414; P=0.010).

Conclusions.  There iss a decrease in IGF-1 levels at the first 6 months of life. Umbilical cord IGF-1 level has negative correlations with the weight and length increment at the age of 6 months.


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How to Cite
Mexitalia M, Pardede B, Utari A, Mexitalia M. Insulin-like growth factor-1 and growth in infants 0-6 months of age. PI [Internet]. 16Mar.2021 [cited 25Jul.2024];61(2):89-3. Available from:
Pediatric Nutrition & Metabolic Disease
Received 2020-11-13
Accepted 2021-03-16
Published 2021-03-16