Incidence and predictors of acute kidney injury in children with severe malaria

Folake Moriliat Afolayan; Olanrewaju Timothy Adedoyin; Mohammed Baba Abdulkadir; Olayinka Rasheed Ibrahim; Sikiru Abayomi Biliaminu; Olugbenga Ayodeji Mokuolu; Ayodele Ojuawo

doi:10.14238/pi62.1.2022.44-50

Folake Moriliat Afolayan University of Ilorin, Teaching Hospital, Kwara
Olanrewaju Timothy Adedoyin Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State
Mohammed Baba Abdulkadir Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State
Olayinka Rasheed Ibrahim Department of Paediatrics, Federal Medical centre, Kastina Nigeria
Sikiru Abayomi Biliaminu Department of Chemical Pathology,University of Ilorin and University of Ilorin Teaching Hospital,Kwara State
Olugbenga Ayodeji Mokuolu Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State
Ayodele Ojuawo Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State

DOI: https://doi.org/10.14238/pi62.1.2022.44-50

Keywords: acute kidney injury; pRIFLE; severe malaria; children

Abstract

Background Acute kidney injury (AKI) is an underrecognized complication of severe malaria and an independent risk factor for mortality among children.

Objective To determine the incidence and factors predictive of AKI as defined by the pediatric risk, injury, failure, loss, and end-stage (pRIFLE) criteria in children with severe malaria and to assess in-hospital mortality rates in malarial AKI (MAKI).

Methods This was a prospective cohort study in 170 children aged 0.5 to 14 years with confirmed Plasmodium falciparum on peripheral blood smears and clinical and/or laboratory features of severe malaria. Serum creatinine was determined using the Jaffe method and glomerular filtration rate (eGFR) was estimated using the Schwartz equation. The primary outcome was the incidence of AKI as defined by the pRIFLE criteria. Secondary outcomes included in-hospital mortality comparison between AKI and non-AKI groups, as well as factors predictive of AKI.

Results The incidence of MAKI was 61.2% (104/170) and was comparable between males (66.7%) and females (70.6%). Mean eGFR was lower among children with AKI than those without [42.00 (SD 22) vs. 98.7 (SD 3.9) mL/min/1.73m², respectively; P=0.005]. Children with MAKI were categorized as having risk (47/104; 45.2%), injury (33/104; 31.7%), or failure (24/104; 23.1%). Mortality rates in AKI and non-AKI subjects were comparable (4.8% vs. 4.6%; P=0.888). Predictors of MAKI were hemoglobinuria [adjusted OR (aOR) 3.948; 95%CI 1.138 to 8.030], deep acidotic breathing (aOR 2.991; 95%CI 3.549 to 66.898), and longer hospital stay (aOR 2.042; 95%CI 3.617 to 12.156). Children with MAKI were more likely to have a longer hospital stay by a mean of 2.5 days.

Conclusion AKI is a common complication in children with severe malaria. MAKI has a low mortality rate comparable to those with severe malaria but without AKI. Hemoglobinuria, deep acidotic breathing, and longer hospital stay were predictive of MAKI.

Author Biographies

Olanrewaju Timothy Adedoyin, Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State

Adedoyin OT, is a professor of Paediatrics at the University of Ilorin and a consultant Paediatrician at University of Ilorin Teaching Hospital

Mohammed Baba Abdulkadir, Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State

Abdulkadir, M.B is a Senior Lecturer at the University of Ilorin and a consultant Paediatrician at University of Ilorin Teaching Hospital

Olayinka Rasheed Ibrahim, Department of Paediatrics, Federal Medical centre, Kastina Nigeria

Ibrahim OR is a consultant paediatrician at the Federal Medical Centre Kastina Nigeria

Sikiru Abayomi Biliaminu, Department of Chemical Pathology,University of Ilorin and University of Ilorin Teaching Hospital,Kwara State

Biliaminu SA is a consultant Chemical Pathologist at the University of Ilorin andUniversity of Ilorin Teaching Hospital

Olugbenga Ayodeji Mokuolu, Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State

Mokuolu OA is a professor of Paediatrics at the University of Ilorin and a consultant Paediatrician at University of Ilorin Teaching Hospital

Ayodele Ojuawo, Department of Paediatrics and Child Health, University of Ilorin and University of Ilorin Teaching Hospital,Kwara State

Ojuawo A is a professor of Paediatrics at the University of Ilorin and a consultant Paediatrician at University of Ilorin Teaching Hospital

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