Phototherapy and serum calcium levels in full term neonates with hyperbilirubinemia

Main Article Content

Carissa Lidia
I Made Kardana
Gusti Ayu Putu Nilawati
Ida Bagus Subanada
I Gusti Agung Ngurah Sugitha Adnyana
Ayu Setyorini Mestika Mayangsari

Abstract

Background Hyperbilirubinemia is one of the most common problems in newborns. Severe hyperbilirubinemia, known as kernicterus, can suppress O2 consumption and oxidative phosphorylation, as well as damage brain cells, resulting in neuronal dysfunction and encephalopathy. Phototherapy is a common therapy for neonatal hyperbilirubinemia, but may rarely lead to the adverse effect of hypocalcemia.


Objective To investigate serum calcium levels in full term neonates with hyperbilirubinemia, before and after phototherapy.


Methods This cohort study compared total serum calcium level before and after phototherapy in full term neonates with hyperbilirubinemia. Subjects were full term neonates aged 2-14 days with high total serum bilirubin levels, according to the Bhutani curve, and were treated with phototherapy at Sanglah Hospital, Denpasar, Bali, Indonesia. Paired T-test was used to compare serum calcium levels before and after phototherapy.


Results There were 35 subjects in this study. Paired T-test revealed that subjects’ serum calcium significantly decreased after phototherapy [before: 9.47 mg/dL vs. after: 9.23 mg/dL; mean difference 0.24; (95%CI 0.03 to 0.46; P=0.025)]. None of our subjects had hypocalcemia after phototherapy.


Conclusion Full term neonates with hyperbilirubinemia have reduced serum calcium levels after phototherapy.

Article Details

How to Cite
1.
Lidia C, Kardana IM, Nilawati GA, Subanada IB, Adnyana IGA, Mayangsari AS. Phototherapy and serum calcium levels in full term neonates with hyperbilirubinemia. PI [Internet]. 11Jan.2021 [cited 7Mar.2021];61(1). Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2489
Section
Neonatology
Author Biographies

Ida Bagus Subanada, Department of Child Health, Universitas Udayana Medical School/Sanglah Hospital, Denpasar, Bali

 

 

Ayu Setyorini Mestika Mayangsari, Department of Child Health, Universitas Udayana Medical School/Sanglah Hospital, Denpasar, Bali

 

 

Received 2020-09-24
Accepted 2021-01-11
Published 2021-01-11

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