Comparative efficacy study of combination fansidar-sulphate-quinine and fansidar-hcl-tetracycline in falciparum malaria in children above 7 years old

Main Article Content

K. Silitonga
T. H. Rampengan


The objective of this study is to compare the results of treatment of children with falciparum malaria with the combinations of fansidar-su/phate quinine and fansidar-chlortetracycline as an alternative treatment of chloroquine'resistant falciparum malaria.

This study was carried out prospectively on 45 cases with the age equal or above 7 years, who had been admitted in the Pediatric Department, Gunung Wenang Hospital, Manado, during the period of January 1989- December 1989. Twenty three cases had been treated with fansidar - sulphate quinine and 22 cases with fansidar-chlortetracycline, all of them underwent blood examinations for malaria for 7 consecutive days (day 0-8).

Asexual parasitemia and fever in the fansidar-sulphate quinine group significantly disappeared more rapidly than in the fansidar-chlortetracycline group (P <0.03 and <0.005). There occurred neither drug resistance nor serious side effect in both groups.

Article Details

How to Cite
Silitonga K, Rampengan TH. Comparative efficacy study of combination fansidar-sulphate-quinine and fansidar-hcl-tetracycline in falciparum malaria in children above 7 years old. PI [Internet]. 5Jun.2020 [cited 13Aug.2020];31(3-4):111-. Available from:
Infection & Tropical Pediatrics
Received 2020-06-05
Published 2020-06-05


l. ADHYATMA: Malaria. Tes resistensi in vivo dan in vitro untuk plasmodium falciparum. Dep. Kes. R.I., Dit. Jen: P3M., jilid 9 (1984).
2. CHONGSUPHAJAISIDDHI, T.; SABACHORN, A.; ATTANATH, P.: Treatment of quinine resistant falciparum malaria in Thai children. Southeast Asian. J. trop. Med. ~ub. Hlth. 14: 357-362 (1983).
3. COLWELL, E.J.; HICKMAN, R.L.: Quinine ,tetracycline .and quinine bactrim treatment of acute falciparum in Thailand. Ann. trop. Med. Parasit. 67 : 125 (1973).
4. DAKUNG, L.S.; PRIBADI, W.; ISMED, I.S.: Plasmodium falciparum yang tersangka resisten terhadap klorokuin di Jakarta. Majalah Kedokteran Indonesia 28: 114-116 (1978).
5. HALL, A.P.; DOBERSTYN, E.B.; METTAPRAHING, V.; SONKOM, P.: Falciparum-malaria cured by quini~e followed by sulphadoxine - pyrimethamine. Br. med. J .2: 15-17 (1975).
6. HOFFMAN, S.L.; DIMPUDUS, A.J.; CAMPBELL, J.R.; HARIJANI, A.M.; SUKRI, N.; RUSTAM, D.; PUNJAB!, N.H.; OETOMO, H.S.; HARUN, S.; HEIZMAN, P.: R II and R III type resistance of plasmodium
falciparum to combination of mefloquine and sulphadoxine/pyrimethamine in Indonesia. Lancet 9 : 1039 - 1040 (1985).
7. PRIBADI, W.; DAKUNG, L.S.; ADJUNG, S.A.: lnfeksi plasmodium falciparum resisten terhadap klorokuin dari beberapa daerah di Indonesia. Medika 8 : 689 - 693 (1985).
8. RAMPENGAN, J.; RAMPENGAN, T.H.: Malaria tropika pada anak yang resisten If terhadap fansidar . Majalah Kedokteran Indonesia 38 : 77 - 80 (1988).
9. RAMPENGAN, T.H.; RAMPENGAN, J.: Chloroquin resistant falciparum malaria in children. Paediatr. Indones. 29: 13- 19 (1989).
10. SABACHORN, A.; CHONGSUPHAIJISIDDHI, T.; ATTANATH, P.: Serum quinine concentrations following the initial dose in children with falciparum malaria. Southeast Asian. J. trop. Med. Pub. Hlth. 13: 556-561 (1982).
11. VERDAGER, J.; ARWATI; SIMANJUNTAK, C.H.; SAROSO, J.S.: Chloroquine resistant falciparum malaria in East Kalimantan Indonesia. J. trop. Med. Hyg. 3 : 58-66 (1976).
12. WARHUST, D.C.: Anti malarial drugs an update. Medical Progress. August: 57-71 (1987).
13. WERNSDORFER, W.H.; KOUZNETZOV, R.L.: Bulletin of the WHO 58 (3): 341-352 (1980).
14. W.H.O.: Advances in malaria chemotherapy. WHO technical report series 711: 61 (1984).