Hepatitis A in children: evaluation of atypical manifestations

Main Article Content

Derya Kalyoncu
Nafiye Urganci
Seda Geylani Gulec

Abstract

Background  Although hepatitis A infection is known as a benign, self-limited disease without chronicity, the rate of complications increases over time.


Objective To evaluate atypical manifestations of hepatitis A infection in children.


Methods A total of 130 children with hepatitis A infection were reviewed. Subjects’ demographic and clinical characteristics, laboratory examinations, and clinical courses were evaluated retrospectively.


Results Twenty-one subjects had atypical manifestations of disease as follows: immune thrombocytopenic purpura (1 patient), pleural effusion (1), autoimmune hepatitis and hemolytic anemia (1), nephrotic syndrome (2), meningoencephalitis (2), autoimmune hepatitis (2), acalculous cholecystitis (3), relapsing hepatitis (4), and fulminant hepatitis (5). Only gender was significantly different, with males having more atypical manifestations than females (P=0.03). Mortality rate was 3% (3 patients with fulminant hepatitis and 1 with meningoencephalitis died in the intensive care unit).


Conclusion Although hepatitis A virus infection has a benign, self-limited course without chronicity, recognition of atypical cases which carry mortality risk is important.

Article Details

How to Cite
1.
Kalyoncu D, Urganci N, Geylani Gulec S. Hepatitis A in children: evaluation of atypical manifestations. PI [Internet]. 3Aug.2020 [cited 27Oct.2020];60(5):239-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2392
Section
Pediatric Gastrohepatology
Author Biography

Seda Geylani Gulec, SBU Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Associated Professor

Received 2020-03-04
Accepted 2020-08-03
Published 2020-08-03

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