Do low vitamin D levels facilitate renal parenchymal injury?

Main Article Content

Mervan Bekdas
Billur Calıskan
Seyda Karabork
Seher Acar
Nimet Kabakus


Background Decreased vitamin D levels lead to an increase in infectious diseases, including urinary tract infections (UTIs).

Objective To assess serum vitamin D levels in children with renal parenchymal injury secondary to UTIs.

Methods Forty-three upper UTI patients and 24 controls, aged 1–15 years, were included.  Vitamin D levels and other laboratory tests were obtained when they first admitted to hospital. 99mTc-labeled dimercaptosuccinic acid (DMSA) scans were performed to evaluate renal parenchymal injury.

Results Mean serum 25-hydroxyvitamin D (25(OH)D) was lower in the upper UTI group compared to the control group [18 (SD 9) vs. 23 (SD 10.6) ng/mL, respectively; P=0.045]. The upper UTI group was sub-divided into two groups, those with 22 (51.1%) and without 21 (48.8%) renal parenchymal injury. Mean 25(OH)D was significantly lower in patients with renal parenchymal injury [15.1 (SD 7.1) vs. 21 (SD 9.9) ng/mL, respectively; P=0.03]. The renal parenchymal injury cases were further sub-divided into two groups: 8 patients (36.3%) with acute renal parenchymal injury and 14 (63.6%) with renal scarring (RS), but there was no significant difference in 25(OH)D between these two groups [12.5 (SD 8.9) vs. 16.6 (SD 5.7) ng/mL, respectively; P=0.14).

Conclusion Decreased vitamin D is associated with renal parenchymal injury in children with upper UTIs. However, vitamin D is not significantly decreased in renal scarring patients compared to acute renal parenchymal injury patients.

Article Details

How to Cite
Bekdas M, Calıskan B, Karabork S, Acar S, Kabakus N. Do low vitamin D levels facilitate renal parenchymal injury?. PI [Internet]. 17Jul.2020 [cited 25Sep.2020];60(4):205-1. Available from:
Pediatric Nephrology
Received 2020-01-22
Accepted 2020-07-17
Published 2020-07-17


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