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of sepsis is widely accepted. Infection stimulates the production
of cytokines in various cell types. Tumor necrosis factor-alpha
(TNF-a) is one of the most extensively investigated cytokines in
experimental and clinical sepsis. Tumor necrosis factor-alpha has
been shown to mediate lethality in experimental sepsis.
Objective To evaluate for a possible correlation between TNF-a
level and septic shock in children.
Methods This cross-sectional study was conducted in Manado
from June to September 2011. A total of 40 patients with a
recent diagnosis of sepsis or septic shock were included. Plasma
specimens were collected from subjects for measurement of
TNF-a concentration. Logistic regression analysis was used to
assess the correlation between TNF-a level and sepsis, as well as
the probability of shock in children with sepsis, with P<0.05 as
Results There was a strong positive correlation between
TNF-a level and the probability of shock in children with sepsis
(regression coefficient = 0. 78, P = 0.002).
Conclusions There is a strong positive correlation between
TNF-a level with the probability of shock in children with sepsis.
Higher plasma level ofTNF-a is associated with higher probability
of septic shock.
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