Correlation between tumor necrosis factor-alpha and septic shock in children

Main Article Content

Khrisanti Dinata
Ari L. Runtunuwu
Jose M. Mandei
Julius H. Lolombulan


Background The crucial role cytokines play in the pathophysiology
of sepsis is widely accepted. Infection stimulates the production
of cytokines in various cell types. Tumor necrosis factor-alpha
(TNF-a) is one of the most extensively investigated cytokines in
experimental and clinical sepsis. Tumor necrosis factor-alpha has
been shown to mediate lethality in experimental sepsis.
Objective To evaluate for a possible correlation between TNF-a
level and septic shock in children.
Methods This cross-sectional study was conducted in Manado
from June to September 2011. A total of 40 patients with a
recent diagnosis of sepsis or septic shock were included. Plasma
specimens were collected from subjects for measurement of
TNF-a concentration. Logistic regression analysis was used to
assess the correlation between TNF-a level and sepsis, as well as
the probability of shock in children with sepsis, with P<0.05 as
statistically significant.
Results There was a strong positive correlation between
TNF-a level and the probability of shock in children with sepsis
(regression coefficient = 0. 78, P = 0.002).
Conclusions There is a strong positive correlation between
TNF-a level with the probability of shock in children with sepsis.
Higher plasma level ofTNF-a is associated with higher probability
of septic shock.

Article Details

How to Cite
Dinata K, Runtunuwu A, Mandei J, Lolombulan J. Correlation between tumor necrosis factor-alpha and septic shock in children. PI [Internet]. 28Feb.2013 [cited 19Jul.2019];53(1):1-. Available from:
Received 2016-08-18
Accepted 2016-08-18
Published 2013-02-28


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