Management of childhood Gitelman syndrome: a case study

  • Risky Vitria Prasetyo Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Putu Dian Saraswati Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Ninik Asmaningsih Soemyarso Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Mohammad Sjaifullah Noer Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
Keywords: Gitelman syndrome, management, child

Abstract

Gitelman syndrome is a rare, autosomal recessive, renal tubular salt wasting disorder characterized by hypokalemia, and metabolic alkalosis in combination with significant hypomagnesemia and hypocalciuria.1,2 The prevalence is estimated to be 1 in 40,000 individuals. The condition affects both males and females of all ethnic backgrounds. The prevalence of heterozygotes is approximately 1% in Caucasian populations.2,3
In the majority of cases, symptoms do not appear before the age of six years and the disease is usually diagnosed during adolescence or adulthood. Symptoms, such as transient episodes of muscle weakness and tetany, sometimes accompanied by abdominal pain, vomiting and fever, are often seen in Gitelman syndrome patients. Paresthesias, especially in the face, frequently occur. Remarkably, some patients are completely asymptomatic except for the appearance of chondrocalcinosis at adult age that causes swelling, local heat, and tenderness over the affected joints. Blood pressure is lower than that in the general population. Sudden cardiac arrest has been reported occasionally. In general, growth is normal but can be delayed in those Gitelman syndrome patients with severe hypokalemia and hypomagnesemia.2,4

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Published
2016-07-01
How to Cite
1.
Prasetyo R, Saraswati P, Soemyarso N, Noer M. Management of childhood Gitelman syndrome: a case study. PI [Internet]. 1Jul.2016 [cited 22Nov.2024];56(3):184-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/235
Section
Pediatric Nephrology
Received 2016-08-18
Accepted 2016-08-18
Published 2016-07-01