Treatment of Bronchopneumonia with Spiramycine (Rovamycine)

  • Soejono Soejono Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Moeljono S. Trastotenojo Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Harsoyo N. Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
Keywords: bronchopneumonia; spiramycine; staphyococcus;

Abstract

Fifty-seven children with bronchopneumonia, comprising 32 male and 25 female, were admitted to the Department of Child Health, Dr. Kariadi Hospital, Semarang, during the period of May 1972 - May 1973. Varying in ages between 16 days and 7 years, 36 of them were less than one year old. They were treated with spiramycine (Rovamycine) given orally in a dosage of 50 mg/kg body weight daily in three divided doses. The failure was 9 out of 57 cases (15.8%) and in infants 7 out of 36 cases (19.4%). The culture of infants revealed 36.1% staphylococcus and in older children showed 4.8%. All cases of staphylococcus as a single cause which was treated with spiramycine gave good results. No side effects of spiramycine were noted. The study showed that spiramycine has a value in the treatment of childhood bronchopneumonia especially in staphylococcal injections in infants.

References

1. AUGER, W.J.: An orlglmal method of obtaining sputum from infants and children. J. Pediatr. 15 : 640 – 646 (1939).
2. BENAZET, F. and DUBOST, M. : Apparent paradox of antimicrobial activity of spiramycine. Antibiot. Ann. 112 : 211 (1959).
3. CROFTON, E.C.: Ampicillin in the treatment of pneumonia: a cooperative controlled trial. Br. med. J. 1 : 1329 - 1333 ( 1966) .
4. GARROD, L.P. : The erythromycin group of antibiotics. Br. med. J. 11 : 57 (1957).
5. HANAFIAH; WILAWffiYA; ALATAS, H.; SUTEDJO and AFF ANDY, M. : Efek cedilanid pada pengobatan bronchopneumonia berat. Kumpulan naskah KONIKA I, p. 271 (1968).
6. HUDSON, D.G.; YOSHIHARA and KIRBY, W.M.M.: Spiramycine; clinical and laboratory studies. Arch.
intern. Med. 97 : 57 (1958).
7. JELJASZEWIEZ, J. and GANCERZEWIEZ, M. : Spiramycine in the treatment of infections in children; in
vivo and in vitro studies. Int. Rec. Med. 172 : 80 - 87 (1961).
8. LEPPER, M.H.; SPIES, H.N.; KELLOW, W.F.T. and ROSENTHAL, J. : Spiramycine in the treatment of infection. Antibiot. Ann. 56 : 658 (1955 - 1956).
9. LYDIA, K.: Aetiologi bronchopneumonia di Ba.gian Ilmu Kesehatan Anak, Rumah Sakit Dr. Kariadi Semarang (Wlpublished, 1968).
10. MIMICA, I.; DONARSO, E .; HOWARD, J.E. and LEDERMAN, G.W. : Loog pWlcture in the etiological diagnosis of pneumonia. Am. J. Dis. Child. 122 : 278 (1971).
11. MORSE, I.I. : Staphylococci and other micrococci in bacterial and mycotic infection of man. 4th ed. (Lippincott, Philadelphia. 1965).
12. NUGROHO, S.S.; SULINDRO, K. : pneumonia. Maj. 21 : 259 (1971).
13. PELLERAT, J. : WULUR, H. and Fungsi paru pada Kedok. Indones. The secretion of some antibiotics in the saliva. Presse med. 2135 - 2136 (1963).
14. PINNERT-SINDICO, S.; NINET, L.; PREUD'HOME, J. and COCAR, C.: A new antibiotic : Spiramycine. Antiblot. aam. Proc. second ann. Symp, Antibiot. New York, p. 724 (1954 - 1955).
15. SOEMANTRI, Ag.; SOEDIGBIA, I.; TRASTOTENOJO, M.S.; HARDIMAN and SOEP ARMAN : Pengobata.n bronchopneumonia dengan Ampicillin. KONIKA II (1970) .
16. SOETED.JO, SAMSUDIN and MARKUM, A.H. : Pengobatan bronchopneumonia. Maj. Kedok. Indones.
11 : 61 - 70 (1961).
Published
2019-09-18
How to Cite
1.
Soejono S, Trastotenojo M, N. H. Treatment of Bronchopneumonia with Spiramycine (Rovamycine). PI [Internet]. 18Sep.2019 [cited 23Nov.2024];16(9-10):396-02. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2317
Section
Infection & Tropical Pediatrics
Received 2019-09-18
Published 2019-09-18