Bacterial enteric pathogens and serum interleukin-6 levels in children with acute diarrhea

Main Article Content

Herlina Herlina
Jeanette Irene Manoppo
Adrian Umboh

Abstract

Background Acute diarrhea is currently one of the major causes of morbidity and mortality in developing countries. A wide range of enteric pathogens, including bacteria, is responsible for the pathogenesis of acute infectious diarrhea. Recent studies have shown an increase in acute phase proteins, such as serum interleukin-6 (IL-6) levels, in patients with acute bacterial gastroenteritis. Thus, IL-6 may be a useful marker to differentiate bacterial from non-bacterial enteric pathogens.
Objective To assess for a correlation between bacterial enteric pathogens and serum IL-6 levels in children with acute diarrhea.
Methods We conducted a cross-sectional study from November 2013 to March 2014 in two hospitals in Manado. Subjects were children aged 1-5 years with acute diarrhea and good nutritional status. Subjects’ provided stool samples for bacterial culture and microscopic examination, as well as blood specimens for serum IL-6 measurements. Data was analyzed by linear regression and Pearson’s correlation tests for a correlation between bacterial enteric pathogens and serum IL-6 levels.
Results In children with acute diarrhea, those with bacterial enteric pathogens had significantly higher mean serum IL-6 than those with non-bacterial enteric pathogens (r = 0.938; P < 0.001).
Conclusion Serum IL-6 levels are significantly more elevated in children with acute diarrhea and bacterial enteric pathogens. Therefore, serum IL-6 may be a useful marker for early identification of bacterial gastroenteritis in children aged 1-5 years. [Paediatr Indones. 2016;56:144-8.].

Article Details

How to Cite
1.
Herlina H, Manoppo J, Umboh A. Bacterial enteric pathogens and serum interleukin-6 levels in children with acute diarrhea. PI [Internet]. 1Jul.2016 [cited 26May2019];56(3):144-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/228
Section
Pediatric Gastrohepatology
Received 2016-08-18
Accepted 2016-08-18
Published 2016-07-01

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