Bacterial enteric pathogens and serum interleukin-6 levels in children with acute diarrhea

  • Herlina Herlina Department of Child Health, Sam Ratulangi University Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
  • Jeanette Irene Manoppo Department of Child Health, Sam Ratulangi University Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
  • Adrian Umboh Department of Child Health, Sam Ratulangi University Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
DOI: https://doi.org/10.14238/pi56.3.2016.144-8
Keywords: bacterial enteric pathogen, serum interleukin-6, diarrhea

Abstract

Background Acute diarrhea is currently one of the major causes of morbidity and mortality in developing countries. A wide range of enteric pathogens, including bacteria, is responsible for the pathogenesis of acute infectious diarrhea. Recent studies have shown an increase in acute phase proteins, such as serum interleukin-6 (IL-6) levels, in patients with acute bacterial gastroenteritis. Thus, IL-6 may be a useful marker to differentiate bacterial from non-bacterial enteric pathogens.
Objective To assess for a correlation between bacterial enteric pathogens and serum IL-6 levels in children with acute diarrhea.
Methods We conducted a cross-sectional study from November 2013 to March 2014 in two hospitals in Manado. Subjects were children aged 1-5 years with acute diarrhea and good nutritional status. Subjects’ provided stool samples for bacterial culture and microscopic examination, as well as blood specimens for serum IL-6 measurements. Data was analyzed by linear regression and Pearson’s correlation tests for a correlation between bacterial enteric pathogens and serum IL-6 levels.
Results In children with acute diarrhea, those with bacterial enteric pathogens had significantly higher mean serum IL-6 than those with non-bacterial enteric pathogens (r = 0.938; P < 0.001).
Conclusion Serum IL-6 levels are significantly more elevated in children with acute diarrhea and bacterial enteric pathogens. Therefore, serum IL-6 may be a useful marker for early identification of bacterial gastroenteritis in children aged 1-5 years. [Paediatr Indones. 2016;56:144-8.].

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Published
2016-07-01
How to Cite
1.
Herlina H, Manoppo J, Umboh A. Bacterial enteric pathogens and serum interleukin-6 levels in children with acute diarrhea. PI [Internet]. 1Jul.2016 [cited 22Dec.2024];56(3):144-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/228
Issue
Vol 56 No 3 (2016): May 2016
Section
Pediatric Gastrohepatology

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Received 2016-08-18
Accepted 2016-08-18
Published 2016-07-01