Metastatic pancreatic ductal adenocarcinoma in a teenage girl: A rare disease

Metastatic pancreatic ductal adenocarcinoma

  • Sutaryo Sutaryo
  • Scolastika Dita Kristian Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada - Dr. Sardjito General Hospital, Yogyakarta
DOI: https://doi.org/10.14238/pi60.6.2020.341-4
Keywords: pancreatic ductal adenocarcinoma; pediatric

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is highly uncommon in patients < 20 years of age, at less than 0.1% of population.1 Pancreatic tumors in children and adolescents can develop from endocrine or exocrine cells. The tumor types include solid pseudopapillary tumor, ductal adenocarcinoma, pancreatoblastoma, acinar cell carcinoma, and pancreatic endocrine neoplasm (malignant and benign).2 Other types of tumors may be attached to it or secondarily engage the gland or emerge from other kinds of non-pancreatic cells inside the pancreas. The prevalent type of classic PDAC in adults is highly uncommon in children.  We report here on a fifteen-year old girl with metastatic pancreatic ductal adenocarcinoma (mPDAC), who presented with abdominal discomfort and jaundice.

References

1. Luttges J, Stigge C, Pacena M, Kloppel G. Rare Ductal Adenocarcinoma of the Pancreas in Patients Younger than Age 40 Years An Analysis of Its Features and a Literature Review. Cancer. 2004;100:173-182. doi:10.1002/cncr.11860.
2. Chung EM, Travis MD, Conran RM. Pancreatic tumors in children: radiologic-pathologic corelation. Radiographics. 2006;26:1211-1238. doi:10.1148/rg.264065012.
3. Perez EA, Gutierez JC, Koniaris LG, Neville HL, Thompson WR, Sola JE. Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients. J Pediatr Surg. 2009;44:197-203. doi:10.1016/j.jpedsurg.2008.10.039
4. Yu DC, Perez-Atayde AR, Kozakewich HP, Shamberger RC. Childhood pancreatic tumors: a single institution experience. J Pediatr Surg. 2009;44:2267-72. doi:10.1016/j.jpedsurg.2009.07.078.
5. Rustgi AK. Familial pancreatic cancer: genetic advances. Genes Dev. 2014;28:1-7. doi:10.1101/gad.228452.113
6. Dall’igna P, Cecchetto G, Bisogno G, et al. Pancreatic tumors in children and adolescents: the Italian TREP project experience. Pediatr Blood Cancer. 2010;54:675-80. doi:10.1002/pbc.22385.
7. Shorter NA, Glick RD, Klimstra DS, Brennan MF, Laguaglia MP. Malignant pancreatic tumors in childhood and adolescence: The Memorial Sloan-Kettering experience, 1967 to present. J Pediatrc Surg. 2002;37:887-92. doi:10.1053/jpsu.2002.32897.
8. Sahin IH, Elias H, Chou JF, Capanu M, O’Reilly EM. Pancreatic adenocarcinoma: insights into patterns of recurrence and disease behavior. BMC Cancer. 2018;18(769). doi:10.1186/s12885-018-4679-9.
Published
2020-11-13
How to Cite
1.
Sutaryo S, Kristian S. Metastatic pancreatic ductal adenocarcinoma in a teenage girl: A rare disease. PI [Internet]. 13Nov.2020 [cited 22Dec.2024];60(6):341-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2276
Issue
Vol 60 No 6 (2020): November 2020
Section
Pediatric Hemato-Oncology

Copyright (c) 2020 Sutaryo Sutaryo, Scolastika Dita Kristian

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Received 2019-08-20
Accepted 2020-11-13
Published 2020-11-13