Splenectomy in Idiopathic Thrombocytopenic Purpura : A Clinical Experience

  • Indro Zaeni and Department of Child Health, Universitas Airlangga Medical School/Dr. Soetomo General Hospital, Surabaya, East Java
  • Sukardi Sukardi and Department of Child Health, Universitas Airlangga Medical School/Dr. Soetomo General Hospital, Surabaya, East Java
  • Bambang P. and Department of Child Health, Universitas Airlangga Medical School/Dr. Soetomo General Hospital, Surabaya, East Java
  • Netty R. H. T. and Department of Child Health, Universitas Airlangga Medical School/Dr. Soetomo General Hospital, Surabaya, East Java
  • S. Untario and Department of Child Health, Universitas Airlangga Medical School/Dr. Soetomo General Hospital, Surabaya, East Java
DOI: https://doi.org/10.14238/pi28.11-12.1988.259-66
Keywords: splenectomy; idiopathic thrombocytopenic purpura; ITBp

Abstract

Since 1979 until 1987 there were 4 idiophatic 1hrombocytopenic purpura (ITP) cases who had undergone splenectomy, consisting of 2 males and 2 females. All patients had been treated with prednisone prior to splenectomy, 2 patients received additional cytostatics. The course of the disease prior to splenectomy had been followed in a period of time, varying from 2,5 to 8 years. The effect of treatment was not very statisfying, as both clinical and laboratory reccurrence often happened.

Post spelectomy, the administration of prednisone in 1 case was stopped immediately, in 2 cases it was stopped after 8 months and in 1 case it was continued. After more than 5 years follow up, 3 cases showed excellent clinical and laboratory findings, while I case failed.

References

1. BLOCK, G .E.; EVANS, R.; ZAJTCHUK. R.: Splenectomy for idiopathic thrombocytopenic purpura. Archs Surg. 92 : 484-489 ( 1966).
2. BUSSEL, J.B.; KIMBERLY, R.P.; INMAN, R.D.; SCHULMAN, I.; RUNDLES, C.C.; CHEUNG, N.; SMITHWICK, E.M.; O'MALLEY, J.; BARANDUN, S.; HILGARTNER MW.: Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura. Blood. 62 : 480-486, (1983).
3. CARPENTER, A. F. ; WINTROBE, M.W.; FULLER, E.A.; HAUT, A.; CARTWRIGHT, G.E.: Treatment of idiopathic thrombocytopenic purpura. J.Am.med.Ass. 171 : 1911-1916 (1959) .
4. Me. MILLAN, R.: Chronic idiopathic thrombocytopenic purpura. New Engl.J .Med. 304 : 1135-1146 (1981).
5. ORRINGER, E.; LEWIS, M.; SILVERBERG, J .; ROSENBACH, L.: Splenectomy in chronic thrombocytopenic purpura. J. Chron. Dis.23 : 117-122 (1970).
6. RAMOS, M.E.G.; NEWMAN. A.J.; GROSS, S.: Chronic thrombocytopenia in childhood. J. Pediat. 92: 584-586 (1978) .
7. SCHULMAN, 1. : Diagnosis and treatment: Management of idiopathic thrombocytopenic Purpura. Pediatrics (1964).
8. SIMONS, S.M .; MAIN, C.A.; YAISH, H.M.; RUTZK Y. J.: Idiopathic thrombocytopenic purpura in children. J. Pedial. 87 : 16- 22 (1975).
9. WEINBLATT, M.E.; ORTEGA, J.A.: Steroid responsiveness . Am . J. Dis. Child . 136 : 1064- 1066 (1982).
10. WILDE, R.C.; ELLIS, L.D.; COOPER, W.M.: Splenectomy for chronic idiopathic thrombocytopenic purpura. Archs Surg. 95 : 344-350 (1967).
Published
2019-08-12
How to Cite
1.
Zaeni I, Sukardi S, P. B, T. N, Untario S. Splenectomy in Idiopathic Thrombocytopenic Purpura : A Clinical Experience. PI [Internet]. 12Aug.2019 [cited 24Apr.2024];28(11-12):259-6. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2269
Issue
Vol 28 No 11-12 (1988): November - December 1988
Section
Case Report

Copyright (c) 2019 Indro Zaeni, Sukardi Sukardi, Bambang P., Netty R. H. T., S. Untario

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Received 2019-08-12
Published 2019-08-12