Investigations on the Aetiology and Antibiotic Management of Neonatal Septicemia

Hans Eldih Monintja

doi:10.14238/pi28.5-6.1988.105-15

Hans Eldih Monintja Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta

DOI: https://doi.org/10.14238/pi28.5-6.1988.105-15

Keywords: neonatal septicemia; antibiotic; ceftriaxone; pseudomonas

Abstract

This is a prospective study aimed in identifying the latest aetiological factors of neonatal sepsis in Dr. Cipto General Hospital, Jakarta, and investigating the efficacy of antibiotics treatment especially with ceftriaxone.

This study revealed that the present main causative microorganisms are as follows: Pseudomonas, Klebsiella and E. coli. The case fatality rates being: (1) Standard treatment with ampicillin and gentamycin: 80.9%, (2) S(andard treatment with consomittant ceftriaxone: 20%, (3) Ceftriaxone: 9,52%.

It seems that in facing neonatal septicemia, the initial antibiotic should be the third generation cephalosporine. The second choice is chloramphenicol. However, the causative agent and the sensitivity test should be monitored regularly.

References

1. AMINULLAH, A.; ABDUL LATIEF; MININTJA, H.E.: Septisemia pada bayi baru Iahir. Kumpulan Naskah Ilmiah Subbagian Perinatologi FKUI (1984).
2. CHADWICK, E.G.; YOGEV, R.; SHULMAN, S.T.; WEINFELD, R.E.; PATEL, I.H.: Single dose cefiriaxone pharmacokmet1cs m ped1atnc patients with central nervous system infections. J. Pediat. 102 : 134-137 (1983).
3. CONGENI, B.L.; CHONMAITREE, T.; RAKUSAN, T.A.; BOX, Q.T.: Once daily ceftriaxone therapy for serious bacterial infections in children. Antimicrob. Agents Chemother. 27 : 181-183 (1985).
4. MARTIN, E. : Once daily administration of ceftriaxone in the treatment of meningitis and other serious infections in children. Eur. J. clin. Microbiol. 2 : 509-515 (1983).
5. MARCHOU, B.; T. VAN THO; ARMENGAUD, M.: Diffussion of ceftriaxone in the cerebrospinal fluid. Comparison with other beta lactam antibiotics in dogs with healthy meninges and in dogs with experimental meningitis. Chemotherapy 27: Suppl. I, 37-41 (1981).
6. MAC CRACKEN, G.H.; NELSON, J.D .; GRIMM, L.: Pharmacokinetics and bacteriological efficacy of cefoperazone, cefuroxime, ceftriaxone and moxalactam in experimental Stretococcus pneumoniae and Haemophilus influenzae meningitis. Antimicrob agents chemother. 21 : 262-267 (1982).
7. Me CRACKEN, G.H.; SIEGEL, J.D.; THRELKELD, N.; THOMAS, M.: Ceftria.xone pharmacokinetics in newborn infants. Antimicrob. Agents chemother. 23 : 341-343 (1983).
8. MONINTJA, H.E.; BUDJANG, R.F.; AMINULLAH, A.; SURADI, R.; KADRI, N.: Clinical experiences in neonatal Salmonellosis with particular reference to diarrhea and septicemia. Paediatr. lndones. 23 : 201-216 (1983).
9. MONINTJA, H.E.: Experience with the treatment of neonatal Salmonellosis. To be published.
10. RANUH, IG.N.; SARWONO, E.; HARDJADINATA, D.: Study on the usefulness of clinical manifestations in the diagnosis of neonatal sepsis. Recent advances in perinatal medicine. Proceeding of the third ICMR Seminar November 20th - 21st (1982) Kobe Japan, page 162 - 17 International, Centre for Medical Research Kobe University School of Medicine Kobe, Japan (1983).
11. SCHAAD, U.B.; Me CRACKEN, G.H.; LOOCK, C.A.; THOMAS, M.L.: Pharmacokinetics and bacteriological efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis. J. infect. Dis. 143 : 156-163 (1981).
12. STEELE, R.W.; EYRE, L.B.; BRADSCHEWR, R.W.; WEINFELD, R.E.; PATEL, I.H.; SPICEHANDLER, J.: Pharmacokinetics of ceftriaxone in pediatric patients with meningitis. Antiin.icrob. Agents Chemother. 23 : 191-194 (1983).