Case report of Fanconi syndrome in Wilms tumor

  • Ayu Hutami Syarif Department of General Medicine, Indonesia National Cancer Center - Dharmais Cancer Hospital
  • Edward Usfie Harahap Department of Urology, Indonesia National Cancer Center - Dharmais Cancer Hospital
  • Mururul Aisyi 1. Department of Pediatric Hematology Oncology, Indonesia National Cancer Center - Dharmais Cancer Hospital
DOI: https://doi.org/10.14238/pi60.4.2020.223-5
Keywords: Wilms tumor; Fanconi syndrome; ifosfamide; nephrectomy

Abstract

Fanconi syndrome is a group of clinical manifestations including aminoaciduria, proteinuria, glycosuria, hypophosphatemia, and metabolic acidosis. It may occur after exposure to certain drugs. The most common causes are antiepileptic, antiviral, antibiotic, and antineoplastic drugs.1 The two most common causes in the antineoplastic regimen are cisplatin and ifosfamide. Ifosfamide, a derivative of cyclophosphamide, has been used to treat pediatric solid tumors.2 Its high efficacy in numerous studies has led to its long-term administration for pediatric malignancies, including Wilms tumor. Along with other treatment modalities, ifosfamide considerably improved the survival rate (90%) of Wilms tumor while only a few cases resulted in Fanconi syndrome.1,3,4

Here we illustrate a case of presumed drug induced Fanconi syndrome in a Wilms tumor patient who previously achieved remission for 10 months.

References

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Published
2020-07-07
How to Cite
1.
Syarif A, Harahap E, Aisyi M. Case report of Fanconi syndrome in Wilms tumor. PI [Internet]. 7Jul.2020 [cited 17Apr.2024];60(4):223-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2230
Issue
Vol 60 No 4 (2020): July 2020
Section
Case Report

Copyright (c) 2020 Ayu Hutami Syarif, Edward Usfie Harahap, Mururul Aisyi

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Received 2019-07-15
Accepted 2020-07-07
Published 2020-07-07