The Influence of Pyridoxin in the Theatment of Tetanus Neonatorum

Dianto Dianto; Immanuel Mustadjab

Dianto Dianto Department of Child Health, Universitas Sam Ratulangi/Gunung Wenang Hospital, Manado, North Sulawesi
Immanuel Mustadjab Department of Child Health, Universitas Sam Ratulangi/Gunung Wenang Hospital, Manado, North Sulawesi

Keywords: pyridoxin; tetanus neonatorum; ATS injection

Abstract

During a 2-year-period (1988-1990) 31 patients with tetanus neonatorum were recruited for this study. The patients were divided into 2 groups: The first group (15 patients) was treated with ATS injection, oral metronidazole and amoxycillin, and diazepam suppositoria. The second group (16 patients) was treated with the same regimen, as the first group plus pyridoxin injection 100 mg on the first day followed by 25 mg orally on the next days.

There was no statistical difference in the two groups concerning the gestation period, sex, severity of the disease (p> 0.05), place of delivery (all at home) and mode of delivery delivered by traditional (midwife/dukun).

The mortality of the first group (without pyridoxin) was 60% and the second (with pyridoxin) 37.5% (p < 0.05).

References

1. ADAMS, J.M.; KENNY, J.D.; RUDOLPH, A . .J. : Modern Management of Tetanus Neonatorum. Pediatrics 64 : 472 (1979).
2. BARTEN, J.: Neonatal Tetanus. A Review of 192 cases. Proc. Sth Asian Congress of Obstretrics and Oynaecology, Jakarta, 1971.
3. BYCHENKO, B. : Geographical Distribution of Tetanus in the World, 19S1-1960. Bull. Wid. Hth. Org. 34 : 71 (1966).
4. CAGLAR, M.K. : Pyridoxine in the Treatment of Tetanus Neonatorum. Pediatr. Indones. 29: 233-23S (1989).
S. DAVIDOFF, R.A. : Oamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord. Science, Wash. 17S : 331 -333 (1972).
6. DAUD, S.; ACHMAD, A.; MOHAMMAD, T.: Tetanus Neonatorum (A Preliminary Report of Assessment of Different Therapeutic Regiments). J. trop. Pediat. 27 : 308 (1981).
7. ENDANG, D.H.; DAULAY, A.P.; LUBIS, C.P.; RUSDIDJAS; SIREOAR, H.: Tetanus Neonatorum in Babies Delivered by Trational Birth Attendants in Medan, Indonesia. Pediatr. Indones. 2S : 167-174 (198S).
8. FREEMAN, W.A.; McFADZEAN, J.A.; WHELAN, J .P .F. : Activity of Metronidazole against Experimental Tetanus and Gas Gangrene. J. appl. Bact. 31 : 443-447 (1968).
9. GO DEL, J .C. : Trial of Pyridoxine Therapy for Tetanus Neonatorum. J. infect. Dis. 14S : S47 (1982).
10. ISMAEL, S.; HENDARTO, S.K.; LUMBAN TOBING, S.M.; SOETOMEnGGALO, T.; REDJEKI, S. : Diazepam melalui rektal pada status convulsivus. KONIKA V, Medan, 1981.
11. KASPAN, M.F.; ISMUDIYANTO; YARDANA, I.N.; SUGYANTO, S.; ATMADJI, D. and RANUH, G. : Penggunaan diazepam per rektal pada anak dengan kejang. KONIKA V, Medan, 1981.
12. KNUDZON, F.U. : Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.: Archs. Dis. Childh. S4 : 8SS-8S1 (1979).
13. KRUGMAN, S. and KATZ, S.i.. : Infectious Diseases of children. ed., pp 40941S (The C. V. Mosby 1981).
14. SALIMPOUR, R. :Cause of death in tetanus neonatorum. Study of 233 cases with S4 necropsies. Archs Dis. Childh 52 : 587 (1977).
15. SOETOMENGOOLO, T.S.; PURBOYO, R.H.; HENDARTO, S.K. and ISMAEL, S.: Neonatal Tetanus Treated with Diazepam as Sin&le Antispasmodic Agent. Paediatr. Indone5. 21 : 101-106 (1981).
16. TJANDRA, H. and MUNIR, M. : Neonatal Tetanus. Analysis of 108 cases using a scoring system. Paediatr. Indones. 18: 263-268 (1978).
17. TJANDRA, H.; RAMPENGAN; T.H.; HARYANTO, I.; ARIF, I.D. and MUNIR, M.: Neonatal Tetanus. Evaluation of Treatment and a Proposal for Classification of Severity. Paediatr. lndones. 16 : 34S-3S4 (1976).