Lung ultrasound in diagnosing neonatal respiratory distress syndrome: a meta-analysis

  • Hanum Ferdian Department of Child Health, Universitas Sebelas Maret Medical School/Dr. Moewardi Hospital, Central Java
  • Dian Ibnu Wahid
  • Samad Samad Departement of Child Health, Soeradji Tirtonegoro Hospital, Solo, Central Java
  • Anggun Esti Wardani Department of Radiology, Universitas Sebelas Maret Medical School/Dr. Moewardi Hospital, Solo, Central Java
  • Guntur Surya Alam Departement of Pediatric Surgery, Soeradji Tirtonegoro Hospital, Solo, Central Java
  • Annang Giri Moelyo Department of Child Health, Universitas Sebelas Maret Medical School/Dr. Moewardi Hospital, Solo, Central Java
Keywords: neonatal respiratory distress syndrome; lung ultrasound


Background Neonatal respiratory distress syndrome (NRDS) is commonly diagnosed by clinical sign and symptoms, blood gas analysis, and chest x-ray. In the past, lung ultrasound (LUS) was not standard for NRDS examination. Many studies show that ultrasound diagnostic tool for NRDS is accurate, reliable, low cost, easy to use, and safe because due to no ionizing radiation.

Objective To determine the sensitivity and specificity of LUS in diagnosing NRDS.

Methods This meta-analysis study was conducted LUS as a diagnostic tool for NRDS. Inclusion criteria were all studies from PubMed, Embase, and The Cochrane Library, without any limitation on published journals, as well as using keywords or search terms of ultrasound, neonatal, and respiratory distress syndrome. Statistical analysis was undertaken using MedCalc® version 18.2 software.

Results Seven studies with a total of 580 patients met the inclusion criteria. Proportional meta-analysis obtained random effects models, with total sensitivity of LUS was 97.2% (95% CI for I2 74.24 to 92.88; P<0.0001) and specificity of LUS was 94.8% (95% CI for I2 88.60 to 98.03; P<0.00001).

Conclusion Lung ultrasound should be considered as a diagnostic tool for NRDS because it is high in sensitivity and specificity, inexpensive, safe, as well as limited radiation exposure.


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How to Cite
Ferdian H, Wahid DI, Samad S, Wardani A, Alam G, Moelyo A. Lung ultrasound in diagnosing neonatal respiratory distress syndrome: a meta-analysis. PI [Internet]. 6Dec.2019 [cited 13Jul.2024];59(6):340-. Available from:
Received 2019-06-02
Accepted 2019-12-06
Published 2019-12-06