Acute Lymphoblastic Leukemia in the Department of Child Health, School of Medicine, University of North Sumatera/ Dr. Pirngadi Hospital Medan (1980 - 1988)
Abstract
A retrospective study on acute lymphoblastic leukemia (ALL) was conducted to assess the pattern of childhood ALL at the Subdivision of Pediatric of Hematology, School of Medicine, University of North Sumatera/ Dr. Pirngadl Hospital, Medan, in a period of 8 years (1980 - 1988).
There were 120 cases, consisting of 63 (51.5%) males and 57 (47.5%) females. By the FAB classification (Bennett, 1976; 77.5% ) were found as FAB L1, 25 (20.8%) as FAB L1, and 2 (1.7%) as FAB L 3. The youngest was 4 months old.
The majority of signs and symptoms appeared In the forms of pallor 102 (85%), fever 84 (70%), hemorrhage 52 (43.3%), hepatomegaly 64 (53.3%), splenomegaly 54 (45%) and lymphadenopathy 18 (15%).
On first admission, 76 (63.33%) cases were with a leukocyte count of less than 20,000/ ul, and 72 (60%) with Hb content of less than 5 g/dl. Twenty one cases died In the first year. The received cytostatic protocol; 11 (S2.38'1o) were treated regularly and first remission were found in 8 (72. 73%) cases.
The average of admissions per year for the age group of 2·8 years was higher than the age groups of 0·2 years and 8-16 years (p < 0.05).
References
2. CHAMPLIN R, GALE RP. Acute Lymphoblaltic Leukemia: Recent Advance in Biology and Therapy. Blood 73:2051-2066 (1989).
3. HENDERSON BS. Acute Leukemia: General Consideration. In William. Haematology, 2nd ed, pp. -827 (Mc. Graw-Hill, New York 1977).
4. LEVENTHAL BG. Acute Lymphocytic leukemia; in Behman, Nelson Textbook of Pediatric: 13th ed. pp. 1085-1087 Saunders, Philadelphia-Tokyo 1987).
5. MILLER DR. Acute Lymphoblastic Leukemia; in Bachner. The Pediatric Clinics of North America, sympotium on Pediatrk Hematology. Vol. 27 No. 2 pp. 269·291 (Ssunders, Philadelphia 1980).
6. SALLAN SE, WEINSTEIN HJ. Childhood Leukemia in Nathan, Oski, Hematology of Infancy and childhood. 2nd ed; Vol. II. pp. 979-1013 (Saunders, PHladelphia/Tokyo 1983).
Copyright (c) 2019 Zairul Arifin, Feraluna Nasution, Adi Sutjipto
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Published 2019-05-17
