Graves' Disease and Diabetes Mellitus

  • M. Suttan Assin Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Jusuf Rukman Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Jose R. L. Batubara Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Purnama Wati S. P. Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
DOI: https://doi.org/10.14238/pi32.11-12.1992.327-31
Keywords: Graves' disease; diabetes mellitus; thyroid hormones

Abstract

Thyroid hormones play an important role in the metabolic propesses. Its disturbances will involve several organs, consequently. A 5 year old girl with Graves' diseases, after several weeks of treatment with propylthiouracil (PTV), developed thyrotoxicosis crisis and diabetes mellitus with ketoacidosis; a condition which is usually fatal. Treatment toward the hyperthyroid state overcome the diabetic stage, eventually.

This report is an example of an endocrinological interaction in a hyperthyroid patient. Therefore, the diabetogenic effect of hyperthyroxinemia should not be overlooked.

References

1. Ingbar S H, Weeber K A. The thyroid gland. In William's Textbook of Endocrinology; 6th ed., Saunders-Igaku-Shoin Tokyo 1981; 120-207.
2. Netter F H. The thyroid gland; in Forsham Endocrine system and selected metabolic diseases. The Ciba collection of medical illustrations; New York; Ciba 1965; 46-55. .
3. Adams D D. The presence of an abnormal thyroid stimulating hormone in the serum of some hyrotoxic patients.J.clin Endo Metab 1958; 699-712.
4. Adams D D, Purves H 0, Sirett N E, Beaven D W. The presence of a short-acting abnormal thyroid stimulator in the blood of thyrotoxic patient. J. din Endocr Metab 1962; 22: 623-6.
5. Shishiba Y, Shinizu T, Yoshimura S, Shizume K. Direct evidence for human thyroidal stimulation by IATS- protector. J Clin Endocr Metab 1973; 36 : 517-21.
6.Kozak G P. Diabetes and other endocrinologic disorders; in Marble. White, Bradley, Kral-Joslim's Diabetes Mellitus; 11th ed., Philadelphia; Lea & Febiger 1971; 674-8.
7. Hellman L, Bradlow H L, Zumoff B, Galagher T F. The influence of thyroid hormone on hydrocortisone production and metabolism. J Clin Endocr. Metab 1961; n_: 1231-45.
8. Hilton] G, Black W C, Athos W, McHugh B, Westermann CD. Increased ACTH-like activity in plasma of patients with thyrotoxicosis. J Clin Endocr Metab 1962; 22: 900.
9. Collen R ], Landow E M, Kaplan S A, Lippe B M. Remission rates of children and adolescenes with thyrotoxicosis treated with antithyroid drugs. Pediatrics 1980; 65 : 550-6.
Published
2019-01-30
How to Cite
1.
Assin M, Rukman J, Batubara J, S. P. P. Graves’ Disease and Diabetes Mellitus. PI [Internet]. 30Jan.2019 [cited 10Nov.2024];32(11-12):327-1. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2125
Issue
Vol 32 No 11-12 (1992): November - December 1992
Section
Case Report

Copyright (c) 2019 M. Suttan Assin, Jusuf Rukman, Jose R. L. Batubara, Purnama Wati S. P.

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Received 2019-01-30
Published 2019-01-30